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Biomedical subjects

H H Wolff

Publications and source records attributed to H H Wolff.

At least 145 records · Page 8Linked to original sources
PubMed1978

Angiolymphoid hyperplasia with follicular mucinosis.

Follicular mucinosis is described to our knowledge for the first time in angiolymphoid hyperplasia. In general, follicular mucinosis may be regarded as a peculiar, nonspecific histological reaction pattern in follicular epithelium that may occur on its own or in association with other pathological processes, particularly lymphomas. The unusual and characteristic features of angiolymphoid hyperplasia revealed by electron microscopy are irregular vessels lined by atypical endothelial cells with convoluted nuclei and large cytoplasmic vacuoles.

Alopecia↗
PubMed1978

[Immunoelectron microscopy in dermatology].

The principle of immunoelectronmicroscopic studies using horseradish perpoxidase is described. This method, especially the peroxidase-antiperoxidase multistep technique, reveals more details about the exact localization of immunophenomena in different dermatological diseases. The results of immunological investigations performed on the ultra-structural level in bullous diseases, lupus erythermatosus, vasculitis, and psoriasis are summarized and compared with the immunofluorescent and classical electromicroscopic findings.

Dermatitis Herpetiformis↗
PubMed1978

[Abt-Letterer-Siwe disease. Diagnosis and therapy (author's transl)].

An infant with Abt-Letterer-Siwe disease is reported. The diagnosis was established by histopathology and electron microscopy.--2. Complete remission was achieved with vinblastine and prednisone. Treatment, however, in these cases has to be continued for a longer period of time.--3. Early diagnosis and therapy are important because Abt-Letterer-Siwe disease is lethal in most untreated cases. With adequate chemotherapy, long remissions or cures can be expected in about 70% of the cases.--4. In Abt-Letterer-Siwe disease, the racket-like Langerhans cell granules are found by electron microscopy within the specific infiltrating cells. The demonstration of these organells allows the unequivocal diagnosis in cases with uncharacteristic clinical or histopathological appearance. The same structures are characteristic of Hand-Schüller-Christian disease and of eosinophilic granuloma. The electron microscopic findings confirm the grouping of these three diseases together as "histiocytosis X".

Biopsy↗
PubMed1978

[Genital mycoplasma strains as a cause of male infertility].

Mycoplasma hominis, M. fermentans, M. orale, M. gallisepticum and Ureaplasma urealyticum are able to reduce the motility of spermatozoa. Electron microscopical investigation confirmed an affinity of these mycoplasmas to the structures of the cell-membranes of the spermatozoa. Simultaneously there could be observed extensive destructions in spermatozoa.

Fructose↗
PubMed1977

The ultrastructure of granuloma annulare.

Nine cases of granuloma annulare at different stages of development were investigated electron microscopically. Special attention was given to collagen changes, to the cellular infiltrate, and to vascular changes. The necrobiotic changes of the collagen were: loosening of the fibers at the borders of the bundles; swelling and loss of cross-striation of the fibrils; and complete degradation of the collagen, with precipitation of mucinous and fibrin material and of glycogen. In 2 cases "cross-banded filamentous aggregations" were present. In later stages new collagen synthesis occurred. In the infiltrate, histiocytes/macrophages were seen developing into epithelioid and giant cells. In addition, numerous active lymphocytes and, at later stages, some neutrophils were found. Vascular changes consisted of endothelial swelling and duplications of the basal lamina. A perivascular infiltrate was present, but no distinct vasculitis was seen. Our results indicate that the necrobiosis of the collagen without primary vasculitis may be an initial event in granuloma annulare. A delayed hypersensitivity mechanism is discussed with regard to pathogenesis.

Adult↗
PubMed1977

[Immunopathological findings in herpes gestationis (author's transl)].

Herpes gestationis occurred in a 26-year-old woman during the last weeks of her second pregnancy. Within 8 days of the delivery the disease had progressed to such an extent that systemic treatment became necessary. Whereas pre-delivery treatment had consisted exclusively of local desinfection, and steroid and antibiotic ointments, treatment after delivery also included systemic use of prednisolone. After treatment for 3 weeks the skin changes had disappeared except for minimal pigmentation. Using immunofluorescent microscopy a complement activation in the dermo-epidermal junction and in adjacent clinically healthy skin could be demonstrated: There were massive linear depositions of C3, C1q and C4. In the basal membrane of the epidermis IgM could be demonstrated as an unusual finding. Further immunopathological features were found in the form of an immune complex vasculitis which could be shown during the active phase of the disease.

Adult↗
PubMed1977

The staphylococcal scalded skin syndrome. An experimental histochemical and electron microscopic study.

Histochemical and electron microscopic studies were carried out on the newborn mouse model of the staphylococcal scalded skin syndrome to investigate the mechanism of action of the staphylococcal epidermolytic toxin that causes it. Histochemical studies showed that an intra-epidermal split develops below the subcorneal zone which is rich in catabolic enzymes (the so-called esterase-acid phosphatase-rich band). However, histochemical alterations in the enzyme pattern could not be demonstrated. The earliest change revealed by electron microscopy was a widening of the intercellular space, with the formation of microvilli at the level between the stratum spinosum and stratum granulosum where the split later occurs. A clearing of the peripheral cytoplasm along the cell membranes was also revealed. In pre-split areas, adhesion between cell membranes of adjacent cells seems to be lost; desmosomes continue to hold the cells together but the split develops when these are broken by mechanical pressure. Later, damaged cell membranes may be seen. Extracellular keratinosomes remain unchanged. Although these findings do not agree with the already divergent results of other studies, they help support the findings of all groups that cases of the Lyell syndrome produced by staphylococci do not occur through necrolysis; it is therefore inappropriate to continue applying the term 'toxic epidermal necrolysis' to such cases.

Animals↗
PubMed1977

Loss: a central theme in psychotherapy.

As an essential aim of psychotherapy is to change in order to develop and grow the patient has to give up some mal-adaptive patterns of behaviour and out-of-date values and belief systems. The inevitable losses involved in this process are discussed in detail. The losses the patient has to face when entering therapy are considered first, followed by consideration of the losses he encounters when during therapy he has to change his attitudes towards himself and others, including the giving up of infanitle wishes and illusions and of value systems originally imposed upon him from outside sources. The losses and disappointments he experiences in the therapeutic relationship itself are discussed, and attention is focused on the way in which what is at first experienced as a loss can become the starting point of new developments and lead to a more positive acceptance of his psychic and physical functioning. To achieve these aims the therapist himself needs to learn to adopt a similar, positive attitude towards the losses and limitations involved in his own life experience and therapeutic work.

Attitude↗
PubMed1977

The ultrastructure of mycosis fungoides, of Sezary's syndrome, and of Woringer-Kolopp's disease (pagetoid reticulosis).

Skin lesions of 13 cases of mycosis fungoides, 2 cases of Sézary's syndrome and one case of Woringer-Kolopp's disease were studied. In mycosis fungoides two main cell types were observed: small atypical lymphoid cells, and large atypical lymphoid cells. The small atypical lymphoid cells were characterized by dense nuclei with varying degrees of nuclear lobulation. Normal-appearing lymphocytes and typical mycosis cells were in this cell group. The large atypical lymphoid cells were characterized by large nuclei with little lobulation and by less chromatin condensation, as well as by a more abundant cytoplasm. Their identification is discussed and indications of their possibly being neoplastic or proliferating lymphoblasts are given. In Sézary's syndrome Sézary cells with more lobulated nuclei than in mycosis cells and lymphoblast-like cells as in mycosis fungoides could be found. In Woringer-Kolopp's disease cells similar to Sézary cells aggregated mainly in the epidermis. No interdigitating reticulum cells and no other morphological signs of a specific lymphocyte microenvironment were found in any of the cases.

Dermatitis, Exfoliative↗
PubMed1977

[Unusual picture of a localized argyrosis].

Blue to black patches appeared in the scar of a sectio caesarea performed 30 years ago. Histology and electron microscopy showed a localized argyrosis due to silver suture material used in the operation.

Argyria↗
PubMed1977

[Electron microscopical rapid diagnosis of cutaneous viral diseases].

Electron microscopy by negative staining is a well-known, simple and quick diagnostic method to demonstrate virus particles. A method for routine work is described. The morphology of important viruses of the herpes and pox group is shown. In herpes simplex and zoster, the viruses can be detected in most cases from fresh vesicular fluid, whereas older erosions and crusts are not suitable. Viruses have been shown in all cases of chicken pox, vaccinia inoculata, molluscum contagiosum, and ecthyma contagiosum (orf).

Herpesviridae Infections↗
PubMed1977

Silver-blue nails.

The case is reported of a man with uniformly silver-blue discolouration of all fingernails, with deeper colouring over the lunulae. The nail bed changes resulted from the uncontrolled ingestion of a silver-containing granular powder. The total silver intake was over 15 g. The only other sign of argyrosis was a barely perceptible greyish discolouration over the cheeks and in the sclerae. Biopsies were taken from the nail bed and the cheek. Electron microscopy revealed metallic deposits in elastic fibres and basement membranes. The silver deposition was much heavier in the nail bed than in facial skin. Long-wave ultraviolet light (UVA) and lack of melanin protection seem to be responsible for this phenomenon. Argyrosis and the differential diagnosis of nail discolourations are reviewed.

Aged↗
PubMed1977

[Transient acantholytic dermatosis (Grover)].

The clinical, histopathological, and electron microscopical characteristics of "transient acantholytic dermatosis" (Grover, 1971) are described. Clinically, there are papules with smooth or keratotic surfaces and sometimes papulovesicles. The lesions are mainly distributed on the trunk predominantly of male patients past the age of 40. The disease usually disappears within weeks, but rarely may be protracted. Histologically, focal changes with the epidermis of Dariertype, Hailey-Hailey-type, pemphigus (vulgaris or foliaceus)-type, or spongiotic-acantholytic type, often in combination, are found. This disease seems to be common. Its distinctiveness should be confirmed by further observations.

Acantholysis↗
PubMed1976

[Sebaceous filaments (author's transl)].

Sebaceous filaments are cylindrical tubes of whitish-yellowish color, which can be expressed from areas of the face rich in sebaceous follicles by pinching the skin or by the cyanoacrylat-technique. Sebaceous filaments are most commonly found in the centrofacial areas and the alae nasae in postpuberal individuals with large facial pores and seborrhea. Sebaceous filaments are composed of a skeleton of 10-30 horny cell layers which enclose a mixture of bacteria, sebaceous lipid, corneocyte fragments and one hair. Following the expression of the filament the follicle refills within 30 days. The various portions of sebaceous follicles (acro- and infrainfundibulum) and the follicular contents are presented at the light microscopial and ultrastructural level. Follicles containing sebaceous filaments have a conspicuous granular layer and no acanthosis. Sebaceous filaments should be differentiated from a microcomedo and trichostasis spinolosa. They are a common morphological variant of sebaceous follicles.

Acne Vulgaris↗