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Biomedical subjects

H Higashiiwai

Publications and source records attributed to H Higashiiwai.

31 records · Page 2Linked to original sources
PubMed1983

[The present status of mass population screening for cancer of the uterine cervix and the therapeutic results in the detected cases in Miyagi Prefecture].

The mass screening for cervical cancer in the population of Miyagi Prefecture has covered the total 1,078,999 women by March 1981. Invasive cancer of the uterine cervix was discovered in 1032 women, carcinoma in situ in 829. 2) By methods of the examination, the institutional examination was on 72.5% of the examined in 1980. 3) With regards to the rates of examinees by age and the detection rate of the cancer of uterine cervix in 1980, the low detection rate in the age range of 30-50 years whose examination rate was over 20% compares against the high detection rate in the high age range, whose examination rate was low. 4) CAI in years 1965, 1970, 1975 and 1980 were 60.0, 116.7, 193.2 and 229.8 respectively. 5) The 302 cases of invasive cancer detected and treated before the end of 1974 were classified in clinical stages and investigated the results of treatment. The detection in Stage I was in 84.1%, this high percentage being a main factor to make the total treatment results of uterine cervical cancer pushed up to the high figure.

Female↗
PubMed1980

Combination chemotherapy in advanced ovarian cancer.

Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F.Q.C. combination chemotherapy (1-(2-tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.

Antineoplastic Agents↗
PubMed1980

[Studies on immunotherapy of uterine cervical cancer by administration of schizophyllan (SPG) (author's transl)].

This study was designed to investigate effects of immunopotentiator on cervical cancer. We administered schizophyllan (SPG) as immunopotentiator to patients of cervical cancer therapy with irradiation, and examined successively immunological parameters such as blastformation of lymphocytes, skin reaction of PPD, lymphocyte counts, concentration of serum immunoglobulins, and other clinical inspections. Moreover we examined ability of interferon induction of SPG. We also calculated and compared 3 year relative survival rate of the cases administered SPG and historical controls therapy with only irradiation. In patients administered SPG the results revealed: 1) an enhancement of stimulation index of lymphocytes blastformation with PHA, 2) an enlargement of skin reaction to PPD, 3) no effects to number of lymphocytes, serum immunoglobulins, liver function and renal function, 4) an interferon activity on patients' sera of cervical cancer after administration of SPG, and 5) patients administrated SPG had significantly high relative survival rate in comparison with the historical control of cervical cancer cases treated solely by irradiation.

Aged↗
PubMed1979

One case of Burkitt's tumor.

A 15-year-old Japanese female with complaints of abdominal tumor and exophthalmos underwent surgery. Histologically, the tumor showed a starry-sky pattern with the macrophages interspersed among undifferentiated lymphoblastoid cells. Considering the clinical aspects, distribution of tumor deposits, and cytological findings, the tumor was diagnosed as Burkitt's tumor. The patient expired on the 42nd day of hospitalization due to general dissemination.

Adolescent↗
PubMed1979

Cytological diagnosis in dysplasia of the uterine cervix.

Cytologic specimens presenting primarily superficial or intermediate dysplastic cells in the smear obtained by scraping the uterine cervix were defined as mild dysplasia, and those presenting primarily parabasal (or deep layer) dysplastic cells were defined as severe dysplasia. The rate of agreement of the above cytologic diagnosis to the histological diagnosis by target biopsy using the colposcope was 50% and 51% in mild and severe dysplasia, respectively. Specimens containing a few atypical cells which were strongly suspected to be malignant were classified as IIIb. From this group, malignant lesions were found in 48% and severe dysplasia in 35%.

Adenocarcinoma↗
PubMed1979

Cellular changes in severe dysplasia of the uterine cervix progressing to malignancy.

Of a total of 1321 cases of severe dysplasia of the uterine cervix, 237 lesions (18%) were found by punch biopsy and cytological examination to have progressed to carcinoma in situ or microinvasive carcinoma later in the course of follow-up. The changes in exfoliated cells during the progression to malignancy were examined in 95 of the 237 cases. Results obtained were as follows: (1) The ratio of parabasal (immature) cells to the whole dysplastic cells gradually increased in each specimen. (2) Immature dysplastic cells showing increased nuclear membrane tension and irregular staining of the nuclear membrane gradually increased. (3) The number of immature dysplastic cells with finely or coarsely granular chromatin patterns gradually increased.

Adult↗
PubMed1976

Histopathological findings of the ovaries in anovulatory women.

Wedge resection of the ovary was carried out in 45 anovulatory women to study the correlation between the degree of disturbance of ovulation and the histopathological findings. Polycystic ovary was always found in patients with anovulatory cycles. The ovaries in grade 1 amenorrhea showing withdrawal bleeding in response to gestagen alone belonged to the nonspecific type, polycystic type and sclerotic type. These histological changes were relatively mild in many cases. The ovaries in grade 2 amenorrhea showing withdrawal bleeding in response to estrogen and gestagen but not to gestagen alone belonged to the non-specific type, polycystic type, sclerotic type, atrophic type and streak type. Even within the same histological entity, the histological findings of the ovaries were more pronounced in grade 2 amenorrhea than in grade 1 amenorrhea. The patients with primary amenorrhea had only hypoplastic and aplastic ovaries with marked histological abnormalities.

Adult↗
PubMedDate not supplied

Diagnostic efficacy and validity of the ThinPrep method in cervical cytology.

OBJECTIVE: To examine the efficacy of the ThinPrep method, an automated, fluid-based technique for the collection and preparation of exfoliated and aspirated cells in cervical cytology. STUDY DESIGN: A total of 251 patients participated. From each patient a sample was obtained by scraping with a wooden spatula, split and prepared with both conventional Papanicolaou and ThinPrep methods. In the ThinPrep processor, epithelial cells were homogenized in a vial of preservative solution and randomly sampled onto a microscopic slide. From a single vial of sample suspension a series of 10 ThinPrep slides of the same quality were made. All cells were concentrated within an approximately 20-mm-diameter circle in a uniform, thin layer on the ThinPrep slide. RESULTS: Twenty-five percent of the screening area, 10% of the epithelial cells observed and 50% of the screening time were required to arrive at a final diagnosis as compared with the Papanicolaou smear. Virtually complete concurrence was ascertained between the Papanicolaou and ThinPrep diagnoses, for direct agreement of 95.3% and agreement within one diagnostic grade of 99.5%. CONCLUSION: An overall improvement was ascertained in the preparation of microscopic slides and the recognition of abnormal cells with the ThinPrep method.

Female↗
PubMedDate not supplied

Histopathologic criterion of dysplasia of the uterine cervix and its biological nature.

A histopathologic diagnostic standard for abnormal epithelium of the uterine cervix, based on its biological behavior, has been proposed, and dysplasia and carcinoma in situ have been classified according to this standard. Benign dysplasia by this classification may be considered as a benign lesion, and only the lesion which satisfies the standard for atypical dysplasia should be considered as dysplasia, having a significance as a precursor to cervical cancer. This would be clinically convenient.

Carcinoma in Situ↗
PubMedDate not supplied

Nipple discharge cytology in mass screening for breast cancer.

Since 1977 mass screening for breast cancer has been conducted in Miyagi Prefecture, Japan; inspection, palpation and cytologic examination of any nipple discharge are part of the initial screening procedures. Among 149,681 subjects examined, 404 cancer cases and 63 papilloma cases were detected. The nipple discharges from 20,537 women were examined cytologically; of the 61 cancer cases, the smears were positive in 18 cases, suspicious in 7, negative with atypical findings in 12 and negative in 24. Ten of the cancer cases were detected exclusively by the cytologic examination of a nipple discharge. In eight of these ten cancer cases, there was no other initial evidence of the primary tumor. The cytologic diagnosis of discharges without blood from 28 cancer cases was positive or suspicious in 10 cases and negative in 18. Thirty-seven of the papilloma cases were initially detected only by the cytologic examination of a nipple discharge; neither physical examination nor mammography showed any abnormal findings.

Adult↗
PubMedDate not supplied

Presacral neurilemmoma mimicking degenerated subserosal uterine leiomyoma.

A case of presacral neurilemmoma extending into the pelvic cavity is reported. T2-weighted MR sagittal images showed a tumor resembling subserosal uterine leiomyoma with degeneration. CT revealed features distinguishing retroperitoneal neurilemmoma from gynecological tumors. The possibility of retroperitoneal neurilemmoma should be raised when a large pelvic tumor attached to the sacrum is noted on CT or MR study.

Adult↗