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Biomedical subjects

H Horio

Publications and source records attributed to H Horio.

At least 91 records · Page 5Linked to original sources

[Exacerbation of idiopathic interstitial pneumonia after lobectomy for lung cancer].

A 51-year-old man was found to have cancer in the left lung during treatment for idiopathic interstitial pneumonia. He underwent a left upper lobectomy because pulmonary function was judged to be adequate and because the interstitial pneumonia was not severe. After the operation, acute exacerbation of interstitial pneumonia occurred, and respiratory failure developed. Immediate steroid therapy alleviated his condition. Acute exacerbations of idiopathic interstitial pneumonia after pulmonary resection are usually fatal, and cases such as this are very rare.

Disease Progression↗

[A case of bronchogenic carcinoma associated with pulmonary infarction which showed a tumorous shadow].

The patient was 69-year-old male with bronchogenic carcinoma associated with another abnormal shadow in the same left lower lobe. Its shadow was considered whether obstructive pneumonia or intrapulmonary metastasis before thoracotomy. Pathological examination revealed that this lesion was pulmonary infarction. It may be rare that bronchogenic carcinoma is associated with pulmonary infarction showing tumorous shadow. The staging and operative indication of lung cancer should be carefully determined which associate with abnormal shadow on the same lung field.

Aged↗

[A case of tracheal stenosis caused by invasion of recurrent lung cancer palliated with dumon stent after Nd-YAG laser and bouginage using of tracheal tube].

The patient was 67 year-old male with tracheal stenosis caused by invasion of recurrent lung cancer after right upper sleeve lobectomy. He visited to our hospital for the purpose of palliation with tracheal stent. But rigid bronchoscope cannot be passed through its lesion because of severe stenosis. So the bouginage was performed. This method was that tracheal tube was inserted into his trachea through the hole of tracheotomy during six days following Nd-YAG laser therapy. After this treatment, rigid bronchoscope was inserted into the trachea and Dumon stent was placed safely and easily. It seems to be an useful palliation for patients with severs invasive tracheal stenosis.

Aged↗

[Intrathoracic transposition of the muscle flap of the trapezius and rhomboideus in treating empyema].

Intrathoracic transposition of the muscle flaps of the trapezius and rhomboideus was performed simultaneously with an open-drainage thoracotomy in a 66-year-old male with empyema. These muscle flaps obliterated the upper empyema cavity and subsequently made it easier for obliteration the remaining lower empyema cavity. The muscle flaps of the trapezius and rhomboideus are useful in obliteration the upper empyema cavity.

Aged↗

[Squamous cell carcinoma of the lung associated with palmo-plantar hyperkeratosis].

Palmo-plantar hyperkeratosis (PPH) is a diffuse keratoderma of the palms and soles that has been reported to be associated with internal malignancies such as lung and esophageal carcinomas. When PPH is associated with malignancy the prognosis is poor. The present patient was a 48-year-old man with PPH who suffered from squamous cell carcinoma of the lung. The pathological stage was T4N2M1 and the patient died of recurrent tumor 17 months after surgery. Because the prognosis of lung carcinoma associated with PPH is poor, patients with these conditions should undergo frequent medical examinations, which should include chest radiography and cytologic examination of sputum.

Carcinoma, Squamous Cell↗

[Location of pulmonary nodules and evaluation of lymph node size by ultrasonography under thoracoscopy].

We evaluated the usefulness of ultrasonography under thoracoscopy for locating pulmonary nodules and measuring the size of mediastinal and hilar lymph nodes. Using unilateral lung ventilation with a double lumen tracheal tube, ultrasonography was effective in evaluating the condition of completely collapsed lungs. The locations of twelve nodules, including five lung cancers, six inflammatory lesions, and one intra-pulmonary lymph node, with sizes ranging from 4 to 30 mm, were examined by ultrasonography. While all lung cancers and the intra-pulmonary lymph node were located by ultrasonography, only two of six inflammatory lesions were found. In examining mediastinal and hilar lymph nodes, all lymph nodes larger than 10 mm could be seen by ultrasonography. However, the ultrasonography could not distinguish between metastatic and non-metastatic lymph nodes. In conclusion, ultrasonography under thoracoscopy was able to locate pulmonary nodules larger than 10 mm, especially lung cancers, and was able to measure the size of mediastinal and hilar lymph nodes larger than 10 mm.

Aged↗

[Use of an expandable metallic stent in patients with superior vena cava syndrome--comparison of angiographic findings and autopsy findings].

To evaluate the usefulness of expandable metallic stens (EMS) in patients with superior vena cava (SVC) syndrome, we compared venographic findings obtained before EMS insertion with findings at autopsy. Stents were inserted into the SVC in 10 patients. An autopsy was done in 7 of the 10 patients. At autopsy, the lumen of the SVC was patent in 4 patients; in those 4 patients venography before EMS insertion showed that the SVC was obstructed by extramural compression. These results suggest that extramural compression without direct invasion of the tumor is the best indication for insertion of an EMS. At autopsy, the lumen of the SVC was obstructed by direct invasion of a tumor in 2 patients; in those 2 patients venography showed wall irregularity and lumen narrowing caused by tumor invasion. However, in those 1 patients SVC syndrome either did not recur or recurred in only a mild form after EMS insertion. The results in these 2 patients suggest that if collateral circulation does not develop, insertion of an EMS is indicated also in patients in whom the SVC is obstructed by direct invasion of a tumor. In the remaining patient, the lumen of the SVC was found at autopsy to be obstructed by a thrombus. SVC syndrome developed in this patient 430 days after EMS insertion. In 1 of the 7 patients, an EMS was inserted into the left innominate vein and also into the SVC. Venography before EMS insertion showed that the vein was obstructed by extramural compression without direct invasion of the tumor, but the EMS was found at autopsy to be completely obstructed by a thrombus. This suggests that insertion of an EMS into the left innominate vein is not indicated this vein is easily obstructed by thrombi because of its anatomical location.

Adult↗

Computational fluid mechanical study of the convective heat transfer in a closed space simulating an infant incubator.

The uneven distribution of the ambient temperature in a model of an infant incubator was demonstrated using the computational fluid mechanical (CFM) simulation of the air flow. A finite volume method of CFM calculation was performed on a three-dimensional (3D) model of an infant incubator including a model baby. The time course of the temperature distribution was computed solving the heat transfer equations simultaneously with the momentum equations. An uneven temperature distribution was observed for a long period (60 s) after the warm inflow was introduced into the incubator chamber. The temperature distribution was complex in 3D space and unsteady even after a long time, suggesting that it may take a considerable time to settle and may continue to be unsteady even if the inflow velocity is steady.

Computer Simulation↗

[Recurrence of a stage I thymoma after resection].

A 61-year-old man had a non-invasive thymoma. The tumor recurred in the aortocaval groove 6 months after thymothymectomy. The second tumor was a non-invasive, lymphocytic thymoma with polygonal cells, and was similar to the first one. The tumor may have been a multicentric thymoma, with malignant cells remaining in thymic tissue behind the brachiocephalic veins. To resect thymomas, extended thymectomy should be done to prevent recurrence from the remaining thymic tissue. CT scans should be obtained for long-term follow up after surgery, to detect any recurrence in its early stage.

Follow-Up Studies↗

[Thoracoscopic wedge resection of small pulmonary nodules--evaluation of Endofinger and colored collagen injection techniques for localization of pulmonary nodules].

We analyzed problems occurring during thoracoscopic resection of small pulmonary nodules less than 2.0 cm in size and evaluated the Endofinger and colored collagen injection techniques, which are new methods for localization of pulmonary nodules. The Endofinger is a device for thoracoscopic palpation and the colored collagen is a long-lasting point marker, composed of 1.0% athelocollagen, methylene blue and contrast medium. Twenty five consecutive patients (male: female = 13:12, mean age 59.0 years) underwent thoracoscopic wedge excision of pulmonary nodules. The mean diameter of the nodules was 1.3 cm (range: 0.4-2.0 cm) and the mean distance from the pleural surface to the nodules, as assessed by CT scan, was 1.1 cm (range: 0-3.8 cm). Methods of pulmonary nodule identification were thoracoscopic inspection only (4 cases), palpation through min-thoracotomy (13 cases), Endofinger (2 cases) and Endofinger with colored collagen injection guided by CT scan (6 cases). In all cases where location was difficult to identify, the nodule diameter was less than 1 cm and the distance from the pleural surface to the nodule was greater than 1 cm. The Endofinger and colored collagen injection techniques have made it easier to localize small pulmonary nodules, decreasing the frequency of cases where additional thoracotomy is necessary. Seven of 25 nodules were revealed to be so-called early peripheral lung cancers, but no relapses were found in any of these cases following pulmonary resection. The new Endofinger and colored collagen injection techniques are useful in the localization of small pulmonary nodules, making thoracoscopic wedge resection of help in early diagnosis and treatment of pulmonary malignancy.

Biopsy↗

[A case of survival for 50 months after resection of cerebellar metastasis of squamous cell lung carcinoma].

The patient was a 64-year-old male with squamous cell carcinoma of the left lung, associated with intrapulmonary metastasis. Eleven months after lobectomy, a single metastasis occurred in the left cerebellum. This was resected, and radiation therapy was performed. Fifty months after the resection, the patient is still alive without recurrence. Based on the present case, we consider that, in the case of single brain metastasis, surgical therapy is desirable because long-term survival can be expected with surgical resection even for a cerebellar metastasis.

Carcinoma, Squamous Cell↗

[Postoperative changes of maximum inspiratory and expiratory pressures in 3 pneumonia cases occurring after surgery for empyema].

We examined preoperative and postoperative maximum inspiratory (MIP) and expiratory (MEP) pressures in 3 cases who died of postoperative pneumonia occurring more than one month after open drainage thoracotomy for empyema. All cases showed reduction of MIP and MEP to less than 20 cmH2O one month after surgery, then suffered of pneumonia. On the other hand, the other 3 cases with empyema who underwent open drainage thoracotomy and recovered without complication showed recovery of MIP and MEP one month after surgery. In conclusion, for the cases that underwent thoracic surgery, postoperative MIP and MEP are the index of respiratory condition such as deep diaphragmatic breathing and ability of efficient coughing, and can be an early prediction of late onset pneumonia after thoracic surgery.

Aged↗

[Anteroaxillary thoracotomy for curative surgery in lung cancer].

The method and results of anteroaxillary thoracotomy for curative surgery in lung cancer are reported. A 20 cm incision is made from the axilla past the nipple line. The serratus anterior muscle is divided, but the lattisimus dorsi muscle does not require division. For an upper lobectomy, the fourth intercostal space is divided, and for a lower lobectomy, the fifth intercostal space is divided. By spreading the thoracic opener, the anterior portion of the rib and costal cartilage are disconnected, and the thorax is opened sufficiently. In the posterior portion, the skin, including the lattisimus dorsi muscle is drawn posteriorly ising an "Octopus". By these techniques, the operative field is made large enough for lobectomy and lymph node dissection. Compared to posterolateral thoracotomy, chronic pain following surgery is dramatically reduced. By anteroaxillary thoracotomy we have satisfactorily performed lobectomy and lymph node dissection of 11 non-T 3 or T 4 lung cancers. In conclusion, anteroaxillary thoracotomy can be a useful approach for ordinal lobectomy and lymph node dissection in lung cancer.

Axilla↗

Synchronous reconstruction of the trachea and innominate artery in thyroid carcinoma.

A 50-year-old woman underwent combined resection and reconstruction of the trachea and the innominate artery synchronously for thyroid carcinoma. The pedicled thymus was interposed between the anastomosis of the trachea and the artery. The postoperative course was satisfactory. Synchronous reconstruction of the artery and trachea may thus prove to be safe, and interposition of the thymus flap may be useful in the prevention of secondary graft infection from the tracheal anastomosis.

Brachiocephalic Trunk↗

Modified trap-door thoracotomy for malignancies invading the subclavian and innominate vessels.

Thirteen patients with malignancies which had invaded the subclavian vessels and/or distal border of the innominate vessels were operated on through modified "trap-door" thoracotomy. The modification is the additional resection of the first rib from inside the thorax. Tumors consisted of thyroid cancer in 5 patients, thymic tumor in 3, Pancoast tumor in 3, and lymphoma in 2. Invaded vessels were on the left side in 9 cases, on the right in 3, and bilateral in one. Subclavian and/or innominate veins were resected in 12 cases and reconstructed in 5. The remaining case was treated with resection of the right innominate and subclavian artery and its vascular reconstruction. Compared to original trap-door thoracotomy, the modification provided a more adequate opening in the chest wall and more extensive exposure of the entire subclavian vessels, which made distal vascular control safe and easy. Postoperative complications occurred in one patient, who suffered chylothorax. In conclusion, modified trap-door thoracotomy is a viable and useful approach in the resection of malignancies which have invaded the subclavian and/or distal border of the innominate vessels.

Adult↗

Intrathoracic transposition of the musculocutaneous flap in treating empyema.

Intrathoracic transposition of the musculocutaneous (MC) flaps of the latissimus dorsi and rectus abdominis was performed after open-drainage thoracotomy in 6 patients with empyema. The MC flaps were designed in such a way that the muscle-bearing skin paddle was extended well beyond the distal muscle borders. The MC flaps thus provided substantially larger pieces compared to muscle flaps. With the exception of one patient with persistent bronchopleural fistula whose empyema recurred due to the reopening of the fistula, the thoracic closure was successful in all patients. Postoperative magnetic resonance imaging revealed a well-preserved volume of subcutaneous tissue in the flaps, while the muscle portions of the flaps had atrophied. In conclusion, compared to muscle flaps, MC flaps have the advantages that (1) larger empyema cavities can be obliterated, and (2) the deformity of the thoracic wall can be minimized because of the small range of resected rib segments and well-preserved volume of subcutaneous tissue in the flap long after the transposition. The use of MC flaps is thus indicated for the empyema cavity remaining when a cavity is cleaned up of granulatous tissue with eradication of bronchopleural fistula.

Aged↗

Expanding intrathoracic hemorrhagic lesion penetrating the thoracic wall: a rare complication of chronic tuberculous pleurisy.

The patient was a 72-year-old woman with an expanding intrathoracic hemorrhagic lesion penetrated beyond the thoracic wall and was associated with chronic tuberculous pleurisy. Enhanced computed tomography revealed an extravasation of contrast medium into the lesion. The intrathoracic lesion and its penetrating lesion of the thoracic wall were resected. Microscopic examination revealed a hematoma with papillary structures lined with vascular endothelial cells, simulating organizing thrombus. An expanding intrathoracic hemorrhagic lesion is an extreme type of chronic tuberculous pleurisy, and can cause intrathoracic compression as the lesion increases in size.

Aged↗

Protein 1 (Clara cell protein) serum levels in healthy subjects and patients with bacterial pneumonia.

Serum levels of protein 1 (P1), a Clara cell secretory protein, were studied in 942 healthy subjects in relation to sex, age, and smoking habits and in 117 patients with bacterial pneumonia in relation to prognosis. P1 values in bacterial pneumonia patients at disease onset were compared with those in 234 healthy control subjects matched by sex and age. P1 values in healthy males were highest in those 30 to 39 yr of age and highest in healthy females > or = 70 yr of age but lowest in those 30 to 49 yr of age. P1 values in healthy males were significantly higher than those in females in the 30- to 39-yr age group (p < 0.05). Male smokers showed higher P1 values than nonsmokers, but without a significant difference. P1 values in patients with pneumonia were significantly lower than in control subjects (p < 0.0001). P1 values were significantly lower in patients treated with a respirator than in in patients treated without a respirator (p < 0.05). In 59 patients, whose P1 values could be followed up until the outcome of pneumonia, all 37 recovered patients showed significantly increased P1 values after recovery (p < 0.001), and all 22 who died of their illness showed significantly decreased P1 values just before death (p < 0.01). We thus conclude that P1 serum levels were significantly affected by sex and by the degree of seriousness in bacterial pneumonia.

Adolescent↗