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H J Mallach

Publications and source records attributed to H J Mallach.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Psychopharmacological studies on the interactions between alcohol and oxazepam with regard to reaction behavior. 1st communication. Changes of psychomotor coordination and reaction behavior].

The interactions between oxazepam and ethanol were investigated in a pharmacopsychological study. The results of the psycho-experimental investigations are reported in this paper. The effects of oxazepam and/or ethanol doses given to 14 subjects with known blood concentrations of the respective substances were monitored and compared to placebo effects. - An analysis of the experiments with respect to the psychomotoric responses showed a tendency towards motoric instability under ethanol (A), whereas in the placebo experiment a relatively constant level of efficiency was maintained. In the oxazepam experiment (C) a slowing of the psychomotoric functions was observed. The concomitant influence of ethanol and oxazepam accentuates the motoric instability with a delay of the motoric responses. These effects remain visible, though slightly modified, after the administration of both substances at intervals (E). The experiments showed a decrease in efficiency during continuous exercise, a delayed response to optic and acoustic stimuli, and a retardation of the entire behavioral pattern under the influence of ethanol and oxazepam. The results indicate the existence of marked interactions between ethanol and oxazepam.

Adult↗
PubMed1975

[Pharmacokinetic studies on absorption and excretion of oxazepam in Combination with alcohol (author's transl)].

The influence of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl 2H-1,4-benzodiazepin-2-one (oxazepam, Adumbran) (30 mg) on the effects produced by alcohol (0.75 g/kg) and vice versa was studied in 14 male test subjects using the following scheme: (A) alcohol; (B) placebo; (C) oxazepam; (D) oxazepam and alcohol combined; (E) alcohol given 30 min prior to oxazepam. Blood and serum levels were determined and excretion in the urine was tested during the 7-h duration of the experiment. The blood alcohol curves show a similar course, leading to the conclusion that oxazepam has no influence on the elimination of alcohol. Alcohol retrads the intestinal absorption of oxazepam but, on the other hand, does not show an effect on the specific metabolism of oxazepam.

Adult↗
PubMed1970

[Autopsy fees].

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Autopsy↗