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Biomedical subjects

H Kappeler

Publications and source records attributed to H Kappeler.

11 recordsLinked to original sources
PubMed2000

[Diabetic diet 2000].

Diabetes diet in the year 2000 consists essentially of carbohydrates. 50% to 60% of the total caloric intake has to be taken in form of carbohydrate. Slowly metabolised forms of carbohydrate should be preferred. Fat and proteins should not exceed more than 20% of the respective total caloric intake. Vegetable fats should be preferred compared to animal fats. Patients with type 2 diabetes who should loose weight have to be extremely careful regarding the fat intake. Insulin-dependent diabetics can correct mistakes in the carbohydrate intake by injecting fast insulins provided that they have in-depth knowledge of the mode of action of insulin and dietary experience.

Diabetes Mellitus↗
PubMed1990

[Control of diabetes and late complications].

When insulin was introduced in medical therapy in 1922, it permitted to save diabetics from premature death; however, it has allowed, after a certain period of time, for the appearance of a cohort of chronic complications connected more or less specifically to the degree of hyperglycemia. After a short review of the pathophysiology of the microangiopathy, the authors have tried to demonstrate, on the basis of numerous prospective and retrospective studies in the human as well as in the animal, that an important relationship exists between the degree of glycemic control and the severity of the classical complications, retinopathy, neuropathy and nephropathy. However, the most recent studies have stressed the role of some other factors, not well established in the past, as for example the potential negative impact on retinopathy of rapid normalization of glycemia, following a long period of poor metabolic control. Likewise, high blood pressure, smoking, genetic background, as well as probably also excess of protein intake, do play an important etiopathogenic role. Thus, the simplistic equation hyperglycemia = complications is not completely valid. Microangiopathic risk in insulin-dependent diabetics seems to be low as long as their HbAlc is below 7.5%, and they do not have hypertension and do not abuse tobacco. Finally, the general approach to therapy is redefined: Try to get as close as possible to near-normoglycemia by multiple insulin injections, without causing, however, major hypoglycemia; this should be done very early after the onset of the disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1977

[Feminizing adrenal cortex carcinoma in a 66-year-old man].

Feminizing tumors of the adrenal cortex in man are very rare. The case is reported of a 66-year-old man who had a carcinoma of the right adrenal cortex which produced various steroid fractions. In the primary tumor and in the second reccurrence the estrogens were dominant. In electron microscopy the tumor cells are poorly differentiated. They may be attributed to the fasciculo-reticular layer and show no signs specific for their secretory activity. The patient died 2 1/2 years after onset of the disease. The case is discussed in the light of the pertinent literature.

Adrenal Cortex Hormones↗