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Biomedical subjects

H Kemona

Publications and source records attributed to H Kemona.

At least 37 records · Page 2Linked to original sources
PubMed1998

Nitroblue tetrazolium test in patients with renal tumor in the course of embolization.

The main role of neutrophilic granulocytes is phagocytosis and destruction of phagocytized bacteria. The nitroblue tetrazolium test (NBT), used to evaluate the bactericidal function of granulocytes, was assessed in 45 patients with renal tumour before and 14 days after renal artery embolization. No statistically significant spontaneous test NBT differences were found, compared with control group both before and 14 days after embolization. Following stimulation granulocytes in vitro by LPS of E. coli the ability of granulocytes to reduce NBT was lowered. The differences, as compared with control group, were statistically significant (p < 0.05). Our results indicates considerable impairment of lower metabolic reserve in patients with renal tumour necessary for maximum stimulation.

Adenocarcinoma↗
PubMed1997

[Usefulness of C-reactive protein (CRP) detection for early diagnosis of infectious postoperative complications after gynecologic surgery].

Immunoturbidimetric method was applied to estimate C-reactive protein concentration in blood serum in 32 women aged 47.8 (+/-6.3) years in whom abdominal hysterectomy had been performed. On the 3rd day after the surgery in 11 (34.4%) patients there occurred inflammatory complications followed by evaluated body temperature (38 degrees C and higher), abdominal wound and/or parametrium inflammatory infiltrations. 21 patients recovered without side effects. In the group of patients in whom on the 3rd day or later infection manifestation appeared, greater difference of CRP concentration was detected in 24th hour after operation. These findings are suggestive of the usefulness of estimating blood serum CRP as en early and preclinical marker of postsurgery inflammation process.

Adult↗
PubMed1997

[Morphologic parameters of blood platelets and dysmorphic erythrocyturia in chronic glomerulonephritis].

Dysmorphic erythrocyturia is known as an attribute of glomerular bleeding. During chronic glomerulonephritis the morphological changes of blood platelets were also observed. The subject of our study was to indicate if the common mechanism leading to blood platelets polymorphology and dysmorphic erythrocytes origination in chronic glomerulonephritis is possible. We estimate the count of blood platelets (PLT), mean platelets volume (MPV), platelet distribution weight (PDW) and platelets crit (PCT) in peripheral blood of 46 patients with chronic glomerulonephritis with dysmorphic erythrocyturia (26 with renal sufficiency and 20 with renal insufficiency) and 32 healthy volunteers. The dysmorphic erythrocyturic erythrocytes were examined in first morning urine. We have not demonstrated the correlation of changes in blood platelets morphology with percent dysmorphic erythrocytes in urine. The results of our investigations do not confirm exactly the common mechanism of the morphological changes which were observed. Minimal changes of the blood platelets parameters may be the results of changes in structure of phospholipids platelets membrane as well as less activation of platelets membrane receptors-GP Ia/IIb and GP Ic/IIa.

Adult↗
PubMed1997

The bactericidal activity of blood platelets in patients infested with Entamoeba histolytica/Entamoeba dispar.

Blood platelets participate actively in organism defensive reactions and particularity in antiparasitic immunity. Platelets stimulation can be the result of contact with a parasite, the presence of immunoglobulins, complement and lymphokines. The aim of the study was to evaluate the blood platelets bactericidal activity in the course of amoebiasis. The examination was carried out in the group of 22 patients with E. histolytica/E. dispar, diagnosed on the basis of cyst forms presence in faeces. The results show that blood platelets bactericidal activity is significantly impaired in the course of amoebiasis.

Adolescent↗
PubMed1997

Ultrastructure of bone marrow megakaryocytes in experimental haemorrhagic shock in rats. II. Correlation between ultrastructure of MK cytoplasm and thrombopoiesis.

Ultrastructural evaluation was performed of the MK cytoplasm in the successive phases of experimental haemorrhagic shock in rats. Qualitative abnormalities were revealed in the intracytoplasmic structures of MK. Platelets in the circulating blood were evaluated. A correlation was found between the changes in the intracytoplasmic organelles and the number and biological activity of blood cells. The results obtained indicate significant disturbances in the functioning of the thrombopoietic system in experimental haemorrhagic shock, which are caused by alterations within the intracytoplasmic structures of MK and lead to platelet production from morphologically differentiated but functionally immature MK.

Animals↗
PubMed1995

Bactericidal capability of blood platelets in eutrophic newborns.

Bactericidal activity of the blood platelets from cord blood of 69 eutrophic newborns differed in relation to sex. In female newborns we noted 8.13% killed Staphylococcus aureus ATCC 6538 P, whereas in male newborns only 2.92%. These data point to the role of platelets in unspecific defense against infections.

Blood Bactericidal Activity↗
PubMed1993

[The study of platelet count and phagocytic activity in experimental hemorrhagic shock. I. Comparison of platelet count in blood of left and right heart ventricles].

The evaluation of the number of blood platelets in the left and right heart ventricle observed during haemorrhagic shock has been carried out. It has been stated that the number of blood platelets of the left ventricle outnumber that of the right heart ventricle. The difference is more intense with the prolongation of the time of the survival in the state of shock.

Animals↗
PubMed1993

[Study of platelet count and phagocytic activity in experimental hemorrhagic shock. II. Evaluation of phagocytic activity of platelets].

The platelets phagocytic activity has been measured in rats during experimental haemorrhagic shock determining the per cent of phagocytic platelets and phagocytic index. The authors have the decrease of phagocytic activity of platelets during haemorrhagic shock. Disturbances of phagocytic activity of platelets have been accompanied by changes of their shape and formation platelet aggregates.

Animals↗
PubMed1991

Serum antithrombin III and alpha-2-antiplasmin concentrations in patients with Hodgkin's disease in the course of chemotherapy.

Disturbances in hemostasis in cancer disease frequently occur. This clinical situation may contribute to the spread and metastasis of cancer. The determination of inhibitors controlling hemostasis especially during treatment may be of value for the evaluation of effectiveness of treatment and balancing of hemostasis. Twenty four patients diagnosed with Hodgkin's disease were introduced to our studies. The level of antithrombin III (AT-III) and alpha-2-antiplasmin (alpha-2-AP) in sera were determined before, during and after treatment with MOPP. We found decrease of AT-III concentration before treatment, and chemotherapy increased the level of this inhibitor but still below the level of control. Alpha-2-AP concentration was higher in patients and MOPP application decreased the level below the values found in controls. The determination of concentration of both inhibitors may be important for the evaluation of the effect of treatment in understanding how the disturbances of hemostasis may be equilibrated.

Adult↗
PubMed1991

[Granulocyte acid phosphatase activity in patients with Hodgkin's disease].

In 24 patients with Hodgkin's disease the activity of acid phosphatase was determined in granulocytes. Its level was only half that in the control group. The causes of this low activity of this enzyme may be increased number of cells without it, exocytosis, and possible influence of substances secreted by the neoplasm. It is suggested that the determination of this activity may be indirectly useful for verification of the efficacy of the antibacterial mechanisms, and also of antitumour resistance of the host.

Acid Phosphatase↗
PubMed1990

The activity of neutrophil myeloperoxidase in patients with Hodgkin's disease.

Neutrophil myeloperoxidase activity has been studied in twenty one patients diagnosed with Hodgkin's disease. The presented data indicate no differences in total MPO activity, whereas we observed some differences in the percentage of granulocytes with different degree of scores. Changes in the intensity of reaction may indicate the possibility of exocytosis as a mechanism releasing MPO from the cell to the surrounding area. In peripheral, circulating neutrophils, such a phenomenon seems to be of no avail and may disorganise anti-cancer defence.

Adult↗
PubMed1989

Bacterial capacity of blood platelets in patients suffering from pneumonia.

The percent of bacteria engulfed by blood platelets, surviving in them and killed was determined in these cells taken from 22 patients with pneumonia before the treatment and from 14 patients after the treatment. The mean percent of bacteria phagocytosed by platelets collected before the treatment was 6.28 and by those after the treatment 5.01, being considerably higher than in the control group (3.42). The mean percent of bacteria surviving in platelets taken before the treatment equalled 3.10 and after the treatment 2.36 being also higher than in the control group (1.32). The mean percent of bacteria killed by platelets taken before the treatment was 3.18 and by those taken after the treatment 2.65, being also higher than in the control group. These results seem to indicate that in cases of pneumonia the blood platelets are involved into the antibacterial activity.

Blood Bactericidal Activity↗
PubMed1988

The activity of neutrophil myeloperoxidase in patients with lung carcinoma.

MPO activity in the neutrophils has been evaluated in 25 patients with lung carcinoma. Surprisingly for us we observed no differences between patients and controls in the total MPO activity. However, we noted the increase in the percentage granulocytes with the first and fourth degree of scores in cancer patients in comparison to normal adults. The highest activity was characterized by the distribution of this enzyme not only in granules but also outside them. Any changes in the total activity of MPO may reflect the balance between the factors which may stimulate it as tumor promoters enhancing the production of superoxide anion or the inhibitory effect of plasma. Diffuse enzymatic reaction may be due to some functional abnormalities of phagocytosis or membrane damage by the MPO system. The role of MPO in anticancer mechanisms is briefly discussed.

Adenocarcinoma↗