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Biomedical subjects

H Koop

Publications and source records attributed to H Koop.

At least 145 records · Page 8Linked to original sources
PubMed1979

Amylase/creatinine clearance ratio and tubular proteinuria in acute pancreatitis.

Amylase/creatinine clearance ratio (CAm/CCr), urinary protein concentration and urinary protein pattern were studied in 102 samples from 27 patients with acute pancreatitis and in 46 controls. Raised CAm/CCr, proteinuria and a tubular protein pattern were present in 74, 56 and 96% of the patients, respectively. However, CAm/CCr and proteinuria and CAm/CCr and tubular protein pattern were not correlated. These results do not support the suggestion that an elevated CAm/CCr in acute pancreatitis is due to generalized tubular protein reabsorption failure presenting with tubular proteinuria.

Acute Disease↗
PubMed1979

[Release of pancreatic polypeptide (PP) or secretin after vagotomy (author's transl)].

The question has been risen whether "pancreatic polypeptide" (PP) determination is a suitable index for a successful vagotomy. Three months after truncal vagotomy (TV) there was only a slight postprandial increase of PP levels whereas five years after TV a normal PP response was found compared to controls. Vagal induced PP release was completely abolished after TV. Selective proximal vagotomy did not influence vagal and food stimulated PP release significantly. It can be concluded that PP determination does not prove to be a suitable index for a successful vagotomy.

Humans↗
PubMed1978

Complement system in sodium taurocholate pancreatitis in the rat.

The role of the complement system was studied in Na-taurocholate pancreatitis in rats. Complement activity (CH 50) was determined at various times in the course of pancreatitis. Immediately after induction of acute pancreatitis, serum complement activity declined and massive C 3 deposits could be detected in the vicinity of acinar necroses and necrobioses. After a phase of recovery three to six hours postoperatively a second complement consumption occurred. Lethality rate increased as serum complement activity fell below 50% of preoperative values. The degree of C 3 deposition increased up to six hours. Decline of serum complement activity and deposition within the pancreas seemed to be correlated with histologically demonstrable tissue lesion. The first decline of complement activity in serum is thought to be caused by liberation of complement activating substances within the pancreas due to the detergent action of Na-taurocholate itself. The second decline, however, may be due to the liberation of complement activating and/or destroying enzymes into the blood stream.

Animals↗
PubMed1978

[Involvement of the exocrine pancreas in Wilson's disease? (author's transl)].

A normal exocrine pancreatic function was demonstrated by the secretin-pancreozymin-test in five patients with Wilson's disease either without (n = 2) or with cirrhosis of the liver but without portal hypertension (n = 3). In another patient with cirrhosis of the liver without portal hypertension the pancreas was normal at post mortem examination. In two patients with cirrhosis of the liver and portal hypertension bicarbonate (n = 1) and amylase secretion (n = 2) were diminished. The regression of portal hypertension under therapy with penicillamine in one of the latter cases was paralleled by the return to normal of exocrine pancreatic function. It is concluded that exocrine pancreatic insufficiency in Wilson's disease is dependent on the development and the progression of chirrhosis of the liver and not due to a primary manifestation of the disease itself.

Adolescent↗
PubMed1978

[Provocative gamma GT test in chronic pancreatitis? (author's transl)].

The increase of serum gamma-GT after hormonal stimulation has been reported as a new provocative test in the diagnosis of chronic pancreatitis. The test was suggested to be more sensitive than the serum amylase provocation test. In a clinical study of both tests in 83 consecutive patients the unsensitivity and the high rate of false positive results were demonstrated. Thus these provocation tests do not seem to be valuable in the diagnosis of chronic pancreatitis.

Cholecystokinin↗
PubMed1978

alpha1-Antitrypsin in pancreatic diseases.

Lowered, normal or raised alpha1-antitrypsin levels were found in 81 patients with acute or chronic relapsing pancreatitis and pancreatic carcinoma. 51 patients with chronic pancreatitis did not have alpha1-antitrypsin deficiency. Thus, in contrast to other reports, alpha1-antitrypsin deficiency and chronic pancreatitis do not seem to be in common association.

Chronic Disease↗
PubMed1978

Evaluation of methaemalbumin in acute pancreatitis.

Methaemalbumin (MHA) was measured in 62 patients with acute pancreatitis. In 26 MHA-positive patients the occurrence of renal and pulmonary complications was 65% and 58%, respectively, compared with 3% and 6% in 36 MHA-negative patients. Fatality rate was 54% in MHA-positive and 6% in MHA-negative patients. In 17 MHA-positive cases haemorrhagic pancreatitis was proven at laparotomy or postmortem examination. Thus MHA determination proved to be a valuable diagnostic and prognostic parameter in acute pancreatitis.

Acute Disease↗
PubMed1978

Indomethacin treatment of acute experimental pancreatitis in the rat.

Indomethacin given orally or intramuscularly before or shortly after induction of acute sodium-taurocholate or olive-oil-induced pancreatitis in rats reduced the lethality. Neither the enzyme content of serum, ascites, and pancreatic tissue nor the damage to the organ itself were changed under the influence of indomethacin. Thus a modification of systemic effects of acute pancreatitis may be responsible for the beneficial effect of indomethacin.

Acute Disease↗
PubMed1978

[Pancreatic polypeptide (PP) (author's transl)].

Pancreatic polypeptide (PP) can be reproducible measured in serum and tissue extracts by mean of a standardized radioimmunoassay. Dispite extensive investigations into the biological actions of the polypeptide and a range of radioimmunological measurements in serum and tissue the physiological significance of PP is, at present, unclear. The normal postprandial increase of serum PP levels has been reported to be lacking after vagotomy and reduced in patients with chronic pancreatitis. If these observations can be confirmed then PP measurement may be a clinically usefull criterion as to the effectiveness of vagotomy and as an indicator for chronic pancreatic disease.

Digestion↗
PubMed1977

Peritoneal dialysis in small laboratory animals.

Healthy rats and guinea-pigs were treated with a simple method of continuous peritoneal dialysis for 12, 24 and 48 h. Increasing with time, both animal species developed severe hypoproteinemia and hemoconcentration due to protein loss into the dialyzate fluid. These changes were associated with a high mortality rate, when Sterofundin was used for dialysis. Therefore, protein loss should be substituted and the type of dialyzate must be considered in experimental long-term dialysis using these small laboratory animals.

Animals↗
PubMed1977

Somatostatin therapy of acute experimental pancreatitis.

Because somatostatin (SRIF) reduces exocrine pancreatic secretion, its effect on acute pancreatitis was investigated in rats. Linear SRIF reduced serum amylase and lipase but had no effect on pancreatic necrosis, oedema, leucocyte infiltration, and enzyme content. The mortality rate was not reduced. These results do not recommend the use of SRIF in the treatment of acute pancreatitis.

Acute Disease↗
PubMed1975

Experimental model for peritoneal dialysis in small laboratory animals.

A simple method of performing peritoneal dialysis in rats and guinea-pigs for 48 hours is described. The method appears to be suitable for the experimental investigation of clinical problems although the long term problem of protein loss should not be forgotten when assessing the results of these short term experiments.

Animals↗