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Biomedical subjects

H Krüger

Publications and source records attributed to H Krüger.

At least 55 records · Page 3Linked to original sources
PubMed1990

Organic, including symptomatic, mental disorders (section F0)--results of the ICD-10 field trial.

The natural history of classification systems for the organic mental disorders from ICD-8 through ICD-10 and DSM-III is presented. Out of a total of 31 cases the 6 with a main diagnosis of the F0-section of ICD-10 are described and field trial results analysed in terms of classification errors, goodness of fit, difficulty, and interrater-reliability. Specific categories (instead of "collective categories") were used more frequently and fewer classification errors made on the basis of ICD-10 as compared with ICD-9. The authors suggest that an operationalized differentiation of dementia as one of the core categories would further increase the reliability and clinical practicability of this section.

Adult↗
PubMed1990

Follow-up of antibiotically treated and untreated neuroborreliosis.

Follow-up of 57 patients who suffered from antibiotically untreated acute, monophasic neuroborreliosis 5 to 27 years ago shows no significant difference in comparison with the follow-up of 66 patients who suffered from antibiotically treated acute, monophasic neuroborreliosis during the last 5 years. In both groups, the involution of clinical symptoms and the normalization of pathological CSF findings were nearly identical. We found no significant difference of sequelae between the groups. Following acute neuroborreliosis, neither the antibiotically untreated nor the antibiotically treated patients developed chronic neuroborreliosis. Only in rare cases of primary chronic neuroborreliosis with CNS involvement did we observe convincing effects of antibiotics, which were given mostly in combination with glucocorticosteroids.

Adolescent↗
PubMed1990

Panencephalopathic type of Creutzfeldt-Jakob disease with primary extensive involvement of white matter.

The case of a 66-year-old woman with atypical Creutzfeldt-Jacob disease (CJD) presents several peculiarities. Pathologic examination confirmed a rare CJD case with primary generalized spongiform changes of the white matter and only moderate, but typical changes of the gray matter. Besides an essentially typical clinical course, the patient developed temporary diplopia and vertical eye movement paralysis. Intoxication had been excluded. Isoelectric focusing revealed oligoclonal CSF-IgG. Magnetic resonance imaging studies showed periventricular accentuated flat and striped hyperintense structures. EEG had CJD-typical periodic 1/s synchronous discharges. This case illustrates for the first time that in panencephalopathic type of CJD the cerebral white matter can be involved primarily and more extensively than the gray matter.

Aged↗
PubMed1989

Stability of cell size and nucleolar size in tangle-bearing neurons of the hippocampus in Alzheimer's disease.

Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interactive image processing unit. In affected cells tangle size was measured too. There was no significant difference in neuron size and nucleolar size between affected and unaffected cells. In tangle-bearing cells nucleolar size and cell size were not correlated with tangle size. Since nucleolar volume can serve as an indicator of RNA synthesis of a cell, tangles themselves seem not to disturb nerve cell metabolism.

Aged↗
PubMed1989

Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years.

In 1987, follow-up studies were conducted on 72 patients who had had meningoradiculitis and encephalomyelitis (8 patients) due to Borrelia burgdorferi 5-27 years previously. These patients had not been treated with antibiotics, either during the acute disease or during the interval prior to follow-up studies. The patients had exhibited the typical symptoms of Bannwarth's syndrome during the acute phase. At the follow-up studies, 33 patients showed no, and 23 only mild, clinical residual symptoms including normal CSF findings and low-positive serum IgG borrelia antibody titres (IFT; ELISA). Three patients without sequelae exhibited persistent intrathecal secretion of oligoclonal B. burgdorferi-specific CSF IgG antibodies (Immunoblot; positive borrelia CSF IgG antibody titres). Thirteen patients exhibited mild-to-medium sequelae with persistent intrathecal formation of oligoclonal B. burgdorferi-specific CSF IgG antibodies, up to 21 years after the acute illness. This persistence can be interpreted as an "immunological scar syndrome". Our follow-up studies appear to indicate that neurological manifestations of B. burgdorferi infections are generally (with few exceptions) of a benign nature. Most patients can be classified as having been cured without antibiotic therapy. No late manifestations of chronic progressive CNS borreliosis comparable to that of neurosyphilis have been seen following acute untreated neuroborreliosis.

Adolescent↗
PubMed1989

MRI study of Baló's concentric sclerosis before and after immunosuppressive therapy.

An intra vitam diagnosis of Baló's concentric sclerosis in a 39-year-old male is described. To our knowledge this is the first reported case of ante-mortem diagnosis based solely on magnetic resonance imaging (MRI) findings. MRI showed features unique to this process. After high-dose intravenous therapy with prednisone, the clinical symptoms improved, and MRI showed marked changes of the concentric lesions.

Adult↗
PubMed1989

Extrapyramidal features in central Lyme borreliosis.

We report 5 cases with an extrapyramidal syndrome resulting from Borrelia burgdorferi encephalitis which responded to antibiotic treatment. The acute onset of extrapyramidal features together with diffuse pain can be the leading symptoms of central borreliosis.

Basal Ganglia Diseases↗
PubMed1989

[Pigment dispersion following extracapsular cataract surgery with posterior chamber lens implantation].

Pseudophakic bullous keratopathy is the leading indication for penetrating keratoplasty. Eight cases of postoperative corneal decompensation occurred during 1 year, five of them in 1 month. So far, three of these patients have received corneal grafts. None of the intraocular lenses were removed. Common symptoms are increased intraocular pressure in the immediate postoperative period, deposition of pigment on the corneal endothelium, long-lasting folds in the on descemet's membrane, edema of the corneal stroma, pigment dusting of the iris and anterior chamber angle. The potential role of the following factors is discussed: risk factors, infection, toxic reaction to the intraocular lens, antibiotics, Epinefrin and irrigation solution. The synonym "toxic solution syndrome" is proposed and discussed.

Aged↗
PubMed1988

Heat-resistant inhibitors of protein kinase C from bovine brain.

Bovine brain cytosol is shown to contain two heat-resistant inhibitors of protein kinase C, with the following characteristics: 1. One protein kinase C inhibitor can be easily purified to homogeneity. Evidence is presented that this polypeptide of Mr 19,000 is calmodulin. It inhibits protein kinase C with an EC50 of about 2.5 microM and the inhibition is Ca2+-independent. It inhibits only intact protein kinase C. Removal of the regulatory domain of protein kinase C, by limited proteolysis with trypsin, abolishes the inhibition. 2. Another protein kinase C inhibitory activity has been partially purified. Its Mr is low (Mr 600-700, as estimated by gel chromatography). It is not digested by proteases, is hydrophilic, acid- and alkali-resistant, acts Ca2+-independently, and, in contrast to calmodulin, inhibits even the catalytic fragment of protein kinase C after removal of the regulatory domain by limited proteolysis. This inhibition is, at least partially, due to a competition with ATP. Besides protein kinase C, calcium/calmodulin-dependent protein kinase II is inhibited to a similar extent. cAMP-dependent protein kinase is not affected.

Amino Acid Sequence↗
PubMed1988

Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis.

In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic meningoradiculomyelitis, repeated CSF examination by this technique showed persistent secretion of identical IgG bands. Thus, the specific humoral immune response and the disease activity could be documented over the course of the disease.

Antibodies, Bacterial↗
PubMed1988

The Bereitschaftspotential in preparation to mental activities.

Earlier studies had investigated the Bereitschaftspotential (Bp) under different aspects of muscular activities. The present experiments were designed to test whether the Bp will be affected by the degree of mental load while motor activity is kept constant. Fourteen healthy male subjects had to solve arithmetical tasks under a graduated time pressure (3 categories of tasks). The subjects had to indicate by pressing one of three keys (trigger), which category of task they wanted to solve next. As soon as a key had been pressed, a task appeared on the computer display and disappeared after the time interval corresponding to the selected category. The results had to be entered into a computer via a keyboard. The EEG signals (5 s time constant, 15 Hz upper frequency cut-off) were averaged time-locked to the movement onset, starting 1.5 s before the pressing of the key. Trials with artefacts were rejected from averaging. The Bp was found to be significantly higher when the tasks were to be solved under higher time pressure. We assume that this might be rather an expression of an appropriate self-activation for the expected mental task than due to a different motor preparation.

Adult↗
PubMed1988

[Evaluating performance capacity and assessing disability in alcoholism].

General aspects of the problem of addiction are outlined and followed by a discussion of the organic effects of alcoholism. Internal, neurological, and psychiatric complications in chronic alcoholism are set forth, and their ranking in the assessment process determined. There follow some conclusions relevant to assessment of the alcoholic's incapacity to work.

Alcoholism↗
PubMed1987

[Motion studies at various industrial work sites].

A measuring system based on ultrasound was developed to measure body movement. Movements of cash register operators, of microscope operators and of operators using a magnifying glass were measured. The analysis showed different results. On one hand the operator found it rather difficult to use his full length of his arm (maximum working area) to operate the cash register and a smaller working area was proposed. On the other hand a rigid posture of the head and the shoulder was found to be typical for operators working with microscopes and magnifying glasses. This puts a rather high static load upon the muscular system used to stabilise the back and the neck.

Humans↗
PubMed1987

[Lens implantation in glaucoma. Choice of surgery in various glaucoma situations].

Eyes suffering from cataract and glaucoma often present particular situations which require particular surgical approaches. The technique to be chosen mainly depends on the depth of the anterior chamber, on the state of the pupil, and on whether or not a fistulizing operation has already been performed. According to the given situation, different surgical options need to be considered. Five such different situations are presented and relevant surgical procedures are described. Although lens implantation in glaucoma usually proves to be more difficult than in normal cataractous eyes, careful selection of an appropriate surgical technique usually provides a good surgical result.

Anterior Chamber↗