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Biomedical subjects

H Mörl

Publications and source records attributed to H Mörl.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Nocturnal leg cramps--their causes and treatment].

Organic causes for nocturnal or recumbency leg cramps as venous, arterial, statical, nervous, rheumatical and metabolic diseases such as tetany, diabetes and gout must be excluded. This means also electrolyte disturbances during a medical treatment, for example with diuretics. In addition there is a very high portion of idiopathic cramps. In 22 patients with nocturnal leg cramps a four week double blind study with a combination of quinine sulphate and aminophylline (Limptar) was started. Unequivocally, Limptar significantly reduced the number and the intensity of nocturnal or recumbency leg cramps. There was no influence on angiological and biochemical parameters. Side effects appeared very seldom.

Aminophylline↗
PubMed1980

[Pharmacotherapeutical action on arteriosclerotic vascular diseases with benzarone (author's transl)].

We report the results of a pilot study to evaluate the therapeutical efficiency of Benzarone in a time span of four weeks in 11 male patients with intermittent claudication. Numerous experimental data indicate that there was a statistically significant increase of painless walking distance and a statistically significant decrease of plasma uric acid, cholesterol and triglycerides. Coagulation analyses furthermore show an increase of the factor VIII activity and the plasminogen levels. For the first time, positive results were shown with Benzarone in patients with intermittent claudication.

Arteriosclerosis↗
PubMed1980

[The effects of nicotine on the circulation and metabolism after cigarette smoking with reference to the plasma levels of nicotine and COHb (author's transl)].

The effects after smoking cigarettes with different nicotine content (1.5 mg and 0.08 mg nicotine/cigarette) were investigated in 6 healthy habitual smokers. Carboxyhemoglobin (COHb) and plasma nicotine levels were determined at the same time as circulatory parameters, heart rate and blood pressure together with metabolic parameters like blood sugar, lactate, free fatty acids and plasma dopamine-beta-hydroxylase (DBH) and plasma cortisol. With the exception of COHb the parameters investigated were shown to be dependent on the nicotine levels. For blood pressure, heart rate and lactate the peaks appeared simultaneously with the maximum nicotine levels, whereas for DBH, cortisol, blood sugar and the free fatty acids there was a delayed reaction in comparison with the nicotine levels. The parameters investigated are not affected by COHb with levels up to 5.6 +/- 0.5%. These results show that after cigarette smoking, nicotine causes considerable changes in the circulation and metabolism.

Adult↗
PubMed1980

Is the diurnal increase of fibrinolytic activity influenced by alpha- or beta-adrenergic blockade?

The diurnal increase of fibrinolytic activity in the forenoon was investigated after alpha- and beta-adrenergic blockade in 15 volunteers. Four milligrams propranolol was injected i. v. alone or in combination with 20 mg phentolamine. Neither the beta-blocking agent, propranolol, nor the combination with the alpha-blocker, phentolamine, had any significant effect on the diurnal increase of fibrinolytic activity.

Circadian Rhythm↗
PubMed1980

Acute cardiovascular reactions after cigarette smoking.

The effect of cigarette smoking on the cardiovascular system was determined in the following way: Two cigarettes of relatively high (1.54 mg) and very low (0.08 mg) nicotine content were smoked and compared to sham smoking. After inhalation under standardized conditions there was a relatively high increase of the plasma nicotine levels and a subsequent exponential decrease. Two hours after smoking the levels were still elevated. After 2 low nicotine cigarettes there was a significant small short-term increase. The changes of the pulse rate were directly related to the nicotine levels and the pulse pressure transit time from the heart to the calf and the digital blood flow was indirectly related to them. The regulation of these parameters is exactly related with the nicotine levels probably through the release of catecholamines. The cardiovascular reactions after smoking may indicate the additional myocardial work load after cigarettes of different nicotine content.

Adult↗
PubMed1980

Paradoxical effect of high and low dose aspirin in experimental arterial thrombosis.

The effect of different dosage regimens of aspirin was investigated in an experimental model of arterial thrombosis. A paradoxical effect with an increase of the arterial thrombus growth could be seen after a first single dose of 100 mg aspirin/kg body weight. When the high dose of aspirin was given repeatedly, a thrombus size minor than under low dose aspirin therapy with 10 mg/kg body weight has been observed. Our experimental thrombosis experiments do not provide sufficient evidence to support antithrombotic therapy with low doses of aspirin.

Animals↗
PubMed1979

[Urokinase treatment of phlegmasia coerulea dolens (author's transl)].

Fibrinolysis treatment with urokinase was successfully undertaken in two patients, aged 71 and 76 years, with phlegmasia coerulea dolens. In the first case, with necrosis in the fore-foot, there was significant regression of the necrotic area, but a later limited amputation was still necessary. In the second, with severe heart failure, recurrent pulmonary emboli and hyperosmolar uncontrolled diabetes mellitus, complete healing was achieved. Venous thrombectomy was not possible in these two patients because of the duration of the thrombosis in the veins of the pelvic region, necrosis had already occurred, and the patients' general condition was so serious. The advanced age and arteriosclerotic changes argued against streptokinase treatment. Mean urokinase maintenance dosage of 1000-1500 IU/kg X h, with simultaneous administration of heparin at about 20 U/kg X h, produced no significant side-effects. Minor gastro-intestinal bleeding did not require stoppage of urokinase administration.

Aged↗
PubMed1979

[Diagnosis of peripheral arterial occlusive disease: clinical, haemodynamic and metabolic investigation (author's transl)].

The value of quantitative (venous-occlusion plethysmography), semiquantitative (ultrasound-Doppler method; walking distance; duration of bicycle ergometry) and metabolic (lactate, pyruvate) tests was assessed in 41 patients with arterial occlusive disease of the upper leg type. It was demonstrated that blood pressure measurement using the Doppler method is of great importance. Significant differentiation between normal and impaired blood flow was obtained with venous-occulsion plethysmography for both "first flow" and "peak flow". The diagnostic value as to the degree of peripheral arterial disease was similar for plethysmography and Doppler methods. Duration of bicycle ergometry provided an important pointer to the degree of functional impairment of the affected extremity. The level of lactate and pyruvate in femoral venous blood is suitable more for serial controls and assessment of treatment in patients in whom haemodynamic studies have already clarified the diagnosis of impaired blood flow.

Adult↗
PubMed1979

Evaluation of smoking-induced effects on sympathetic, hemodynamic and metabolic variables with respect to plasma nicotine and COHb levels.

The effect of smoking cigarettes containing 1.5 mg and 0.08 mg nicotine per cigarette and of sham-smoking was studied in six healthy habitual smokers. Levels of carboxyhemoglobin (COHb) and plasma nicotine were measured simultaneously with hemodynamic variables, such as heart rate and blood pressure, and with the metabolic parameters, plasma DBH, cortisol, blood glucose, lactate and free fatty acids. All variables, with the exception of COHb are dose related to plasma nicotine levels. Blood pressure, heart rate and lactate show simultaneous peaks together with maximal nicotine levels, while DBH and cortisol, blood glucose and free fatty acids show a delayed reaction compared to nicotine concentrations. No effects of COHb, even with levels up to 5.6 +/- 0.5% have been observed on the variables investigated. These results demonstrate, that it is nicotine which induces considerable hemodynamic and metabolic alterations after smoking.

Adult↗