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Biomedical subjects

H Møller

Publications and source records attributed to H Møller.

138 records · Page 8Linked to original sources
PubMed1989

Glycosaminoglycans in patellar cartilage.

We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetate electrophoresis, and the relative content of major glycosaminoglycans was measured by optic scanning. The total content of glycosaminoglycans was estimated by uronic acid analysis. We found that degenerated cartilage contained an increase in dermatan sulfate and hyaluronic acid and a decrease in chondroitin 6-sulfate and total uronic acid concentration, with only slight changes in chondroitin 4-sulfate and keratan sulfate compared with normal cartilage.

Adolescent↗
PubMed1988

Measuring progress against cancer.

The trends in age-specific cancer incidence and mortality rates in Denmark were evaluated over the period 1951-1980. The total incidence of cancer increased in all age-groups in both sexes, i.e. the life-time risk for any person of getting a malignancy has been increasing. The mortality from cancer shows a different pattern, especially in the younger age-groups where cancer mortality has been decreasing. The decrease in incidence of gastric cancer, when measured in terms of incidence or mortality rates, has been an important source of success. Screening for precancerous lesions of the cervix has been responsible for a large decrease incidence among younger women. Had it not been for the large increase in the incidence of lung cancer, the total cancer mortality in both sexes would, in nearly all age-groups, have been lower in 1976-1980 than in 1951-1955.

Adult↗
PubMed1988

Risks for respiratory and gastric cancer in wood-working occupations in Denmark.

Cases of cancer notified to the Danish Cancer Registry during the period 1970 to 1984 in the age groups 16 to 66 years have been linked to information on employment kept on file in the nationwide Supplementary Pension Fund since 1964. Industrial hygienists classified industrial groups as defined by the Pension Fund with regard to exposure to wood dust, and a list of industries with major exposure to wood dust was defined. The risk for cancer of the respiratory system and the gastrointestinal tract was evaluated by means of a proportional cancer incidence analysis. A fourfold increase in risk for sinonasal cancer was found among men involved in the manufacture of wooden furniture, and a twofold increase in risk for gastric cancer was seen in all of the component industries of basic wood-processing. In contrast, no excess of gastric cancer could be detected in men working in the manufacture of wooden building materials and wooden furniture, and a risk below unity was seen for those in carpentry and joinery. The elevated risk for gastric cancer in some wood-processing industries is probably due to social factors also common to men in agriculture and manufacturing. The absence of an increased risk for gastric cancer in trades in which a high risk for sinonasal cancer is seen indicates that wood dust is not of aetiological importance for gastric cancer. No excess of total lung cancer or of the adenocarcinoma subtype was seen in any of the wood-processing industries.

Denmark↗
PubMed1988

Incidence of the upper respiratory and digestive tract cancers and consumption of alcohol and tobacco in Denmark.

To study the incidence of upper respiratory and digestive tract cancer in Denmark in relation to changes in tobacco and alcohol consumption, the incidence trends are compared to the figures for average annual consumption during the period 1943-1982. The comparison is made using relative risk estimates available from previous investigations. From the available data on alcohol and tobacco consumption, an attempt is also made to predict the future incidence trends of these cancers. Since no data on the distribution of smoking versus drinking by sex and age are available from Denmark over the study period, two hypotheses are used. It is shown that the predicted incidence is strongly dependent on the distribution of smoking and drinking, and that the existence of a group with heavy consumption of tobacco and alcohol could be responsible for very high incidences of these cancers in the near future in Denmark.

Adult↗
PubMed1987

A phase I clinical evaluation of 1-(2-chloroethyl)-3-[2-(dimethylaminosulphonyl)ethyl]-1-nitrosou rea (TCNU).

TCNU (1-(2-chloroethyl)-3-[2-(dimethylaminosulphonyl)ethyl]-1-nitrosour ea) is a newly developed water-soluble nitrosourea based on the endogenous aminoethanesulphonic acid taurine. TCNU was in an extended phase I trial given orally every 4-8 weeks using a stepwise dose escalation from 20 to 170 mg/m2. One hundred and thirty-nine patients received a total of 323 courses. Minor haematologic toxicity was observed in 12 patients treated at dose levels less than 70 mg/m2. Thrombocytopenia WHO grades 1-4 occurred in 43% (55/127) and leucopenia WHO grades 1-3 in 45% (57/127) of the patients treated at dose levels greater than or equal to 70 mg/m2. Nausea and vomiting was recorded in about half the patients despite the use of metoclopramide. At the initial dose level 41 patients received greater than or equal to 3 courses of TCNU. Cumulative leucopenia and thrombocytopenia occurred in 3/41 and in 12/41 patients, respectively, while reversible hepatotoxicity was observed in two patients. Antitumour activity was observed in patients with advanced squamous cell, adeno- and large cell carcinoma of the lung. The recommended starting doses for phase II trials with TCNU are as follows: heavily pretreated patients 90 mg/m2, minimally/-moderately pretreated patients 110 mg/m2 and previously untreated patients 130 mg/m2 with TCNU given every 4-5 weeks, the repeated doses and intervals being adjusted to individual tolerance.

Adolescent↗
PubMed1981

Incarcerating mediopatellar synovial plica syndrome.

A series of patients with a long history of similar knee symptoms is described. In 79 cases a medial parapatellar fold of the synovial membrane was found. After removal of this fold, at follow-up, 66 patients were completely free of symptoms, 8 had minor complications, 1 was unchanged, 1 was worse, 2 had chronic synovitis and 1 patient admitted to a psychiatric department would not take part in the follow-up.

Adult↗
PubMedDate not supplied

Hearing at low and infrasonic frequencies.

The human perception of sound at frequencies below 200 Hz is reviewed. Knowledge about our perception of this frequency range is important, since much of the sound we are exposed to in our everyday environment contains significant energy in this range. Sound at 20-200 Hz is called low-frequency sound, while for sound below 20 Hz the term infrasound is used. The hearing becomes gradually less sensitive for decreasing frequency, but despite the general understanding that infrasound is inaudible, humans can perceive infrasound, if the level is sufficiently high. The ear is the primary organ for sensing infrasound, but at levels somewhat above the hearing threshold it is possible to feel vibrations in various parts of the body. The threshold of hearing is standardized for frequencies down to 20 Hz, but there is a reasonably good agreement between investigations below this frequency. It is not only the sensitivity but also the perceived character of a sound that changes with decreasing frequency. Pure tones become gradually less continuous, the tonal sensation ceases around 20 Hz, and below 10 Hz it is possible to perceive the single cycles of the sound. A sensation of pressure at the eardrums also occurs. The dynamic range of the auditory system decreases with decreasing frequency. This compression can be seen in the equal-loudness-level contours, and it implies that a slight increase in level can change the perceived loudness from barely audible to loud. Combined with the natural spread in thresholds, it may have the effect that a sound, which is inaudible to some people, may be loud to others. Some investigations give evidence of persons with an extraordinary sensitivity in the low and infrasonic frequency range, but further research is needed in order to confirm and explain this phenomenon.

Acoustics↗