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Biomedical subjects

H Müntefering

Publications and source records attributed to H Müntefering.

At least 55 records · Page 3Linked to original sources
PubMed1979

Virus induced diabetes and the immune system. II -- Evidence for an immune pathogenesis of the acute phase of diabetes.

The infection of normal DBA2 and BALB/C nu/ + mice with 2 X 10(2,6) TCID50 of the M variant of the EMC virus induced pathological mean glucose values of 426 +/- 99 mg/100 ml in DBA2 mice and 292 +/- 130 mg/100 ml in BALB/C nu/ + mice on day five following infection. As diabetic animals died afterwards, mean glucose values decreased in the surviving animals on day seven and fourteen. The infected immunodeficient BALB/C nu/nu mice with thymus aplasia did not show abnormal mean glucose values or higher standard deviation of the means (114 +/- 37 mg/100 ml) when compared to uninfected controls (117 +/- 23 mg/100 ml). This demonstrates that a complete thymus-dependent immune system seems to be necessary for the development of the acute stage of virus-induced diabetes in the mouse.

Animals↗
PubMed1978

Photoinactivation of the encephalomyocarditis virus.

Encephalomyocarditis virus was photoinactivated by a dilution of 1:30,000 neutral red and 70 minutes exposure to light. A dye inactivation of the EMC virus is possible without destruction of its antigenicity. The EMC virus vaccine induced a good immunity response in mice; we did not find any infectious virus.

Animals↗
PubMed1978

Course of coxsackie B antibodies during juvenile diabetes.

Sera of 83 patients with insulin-dependent diabetes of early onset were tested for latex agglutination-inhibiting antibodies to coxsackie virus types B1-B5. We could not find any evidence of a causal association between Coxsackie B virus infection and diabetes.

Adolescent↗
PubMed1977

[Clinically undiagnosed glycogen storage disease type I as cause of postoperative death (author's transl)].

A 30-year-old patient was admitted to hospital for cholecystectomy with a diagnosis of complete obstruction of the cystic duct. The preoperative clinical and chemical findings were normal. Following cholecystectomy the patient recovered normally from the anaesthetic. Three hours later sudden cardiac arrest occurred. Necropsy revealed glycogen storage disease type I. Hypoglycaemia and metabolic acidosis had probably led to hypokalaemia which is considered as the cause of cardiac failure.

Adult↗
PubMed1977

Virus induced diabetes and the immune system. I. Suggestion that appearance of diabetes depends on immune reactions.

The participation of immune reactions in the EMC virus induced diabetes of the mouse was studied by immunosuppression with 500 R sublethal X-irradiation or 120 mg/kg Asta 5122, a cyclophosphamide derivative. Average glucose levels after X-irradiation and infection remained normal, while virus, infected, otherwise untreated mice, had significantly higher mean glucose levels, indicating that immune reactions are necessary for the development of virus induced diabetes. Immune suppression by the cyclophosphamide derivative led, in contrast, to a significantly increased mean glucose level and increased insulitis in comparison with the controls only infected. This indicates an important role of the cellular immune reaction, insulitis in the destruction of the islets.

Animals↗
PubMed1977

[Obstructive thrombosis of the pulmonary trunk: a rare but dangerous late complication of the banding procedure (author's transl)].

This paper presents three cases of obstructive thrombosis of the pulmonary trunk following banding procedure. The complication was lethal for all our patients as well as for the three others reported in the literature. Considering the typical course of the complication, the relatively late onset of cyanosis or its increase in heart diseases with primary right-to-left shunt, the X-ray pictures of the thorax depicting a drastic fall of pulmonary flow, and most of all the angio-cardiographic clues for the presence of an intravasal thrombus, it appears, that the correct diagnosis could be made early enough to permit life saving surgery. The anatomical-pathological findings and the results of histological examination are reported for all three patients.

Child↗
PubMed1975

[A case of goodpasture-syndrome in legal medical practice (author's transl)].

Goodpasture's syndrome (GS) is a very rare diagnosis in forensic post-mortem examinations. This casereport shows, that GS should always be considered as cause of sudden natural death of young adults, if merely unusual disseminated pulmonary hemorrhages represent the essential findings at autopsy. The final diagnosis of GS is made by microscopic evidence of additional diffuse hemosiderosis of the lungs and proliferative glomerulonephritis.

Adult↗
PubMed1975

Virus-induced damage of the myocardial cell.

A total of 330 male 3-week-old mice of the N.M.R.I./Han. strain were infected with the M-variant of the EMC (encephalomyocarditis) virus by subcutaneous inoculation of 0.25 ml of the virus suspension diluted 1:500. Animals were killed at 4- or 6-hour intervals, respectively, and groups of 2 to 8 hearts were taken for virological, morphological, and biochemical studies. Before the 8th hour after the inoculation, no virus and no pathological cell changes could be detected in the hearts; it is assumed, therefore, that there first takes place an extracardiac virus cultiplication. The virus content in the hearts increases from the 12th to the 30th ahour and subsequently maintains that level. Also from the 12th to the 30th hour, electron microscopy reveals increasing damage of the myocardial cells, the course of which is described. In most instances following virus-induced damage of the myocardial cells, the onset of alterations of the blood and lymph capillaries and damage to the interstitial cells were observed...

Animals↗