[Virus induced diabetes mellitus in the white mouse].
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Biomedical subjects
Publications and source records attributed to H Müntefering.
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We describe a 2 3/4-year-old boy with Kawasaki disease associated with the rare complication of acute hydrops of the gallbladder. Because of the severe abdominal symptoms cholecystectomy was performed. A review of the literature shows that about half of the patients had been operated upon. Therefore conservative treatment may provide complete improvement. Ultrasonography is not only very helpful in the diagnosis but also in follow-up.
Congenital absence of both lungs is an extremely rare malformation in humans and is thought to occur sporadically. We report the second case of congenital absence of both lungs in the offspring of one woman. In neither case, one female baby (born at term) and one aborted female fetus (21 weeks of gestation), were anomalies or malformations of other organ systems observed. The karyotype of the aborted fetus was 46,XX. To our knowledge, this is the first report describing bilateral pulmonary agenesis in two offspring of one mother. The repetition of virtually the same isolated abnormality with no other malformations supports the hypothesis that it could be caused by a genetic disorder. Other etiologies previously suggested, such as drugs or viruses, cannot be excluded but seem less likely.
In 253 postterm pregnancies we investigated the correlation between retarded placental maturation, mode of delivery and fetal outcome and tried to answer the question, whether it is possible to estimate placental risk antenatal with pulsed doppler ultrasound of an umbilical artery. Villus maturation was determined by the criteria of Becker and the results were classified into 3 groups: Normal maturity, regionally or disseminated retarded maturation. In the latter group we found the highest rate of cesarean sections for fetal distress and a high neonatal morbidity. The birth weight was lower compared to the cases with normal placental maturity. As an index of placental resistance we determined the (A-B)/A-quotient of an umbilical artery with pulsed doppler ultrasound. The Resistance-Index was increased when the placental maturation was retarded. In 60% of cases with pathological umbilical artery flow velocity waveforms we found disseminated retarded placental maturation, whereas this occurred only in 6% of cases with normal flow.
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Within a group of preeclamptic women we found severe histologic placental pathology with functional relevance when both the uteroplacental and fetoplacental flow velocity waveforms showed elevated resistance indices. These pathological findings were a reduced decidual area, infarction and villus maturation failures with a high rate of intrauterine growth retardation, acidosis and premature delivery. In cases with normal flow velocity waveforms these pathologic findings were much rarer although the patients were preeclamptic, too.
Early and late effects of short-living iodine isotopes on the thyroid of children in Byelarus are described. Early effects manifested with an increase in the thyroid functional activity in children up to one year of age during 1986. Follicular cell hypertrophy is considered as a marker of the radiation effect at a dose level from 0.1 to 1 krad. Late effects are thyroid carcinomas the incidence of which in the country rose ten-fold within the last 5 years.