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Biomedical subjects

H Mathies

Publications and source records attributed to H Mathies.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Programmed diagnosis of rheumatic diseases in general practice (author's transl)].

In the large number of rheumatic diseases and their often very different types - typical symptomatology is seldom complete - a reliable classification of a particular form of disease is often not easy. The "programmed diagnosis" presented here should be a signpost from the clinical picture, by way of the provisional diagnosis and the necessary diagnostic measures, to the final diagnosis.

Arthritis, Reactive↗
PubMed1975

[Problems of definition and of nomenclature in rheumatology (author's transl)].

Rheumatism is the collective denomination for systemic diseases of the locomotor system with possible involvement of internal organs, or on the basis of primary diseases, in particular of infectious, metabolic, endocrinological, hematologic or neurological origin. Problems of nomenclature related to this definition are discussed and examined critically from the linguistic point of view. With the aid of examples the nomenclature of significant rheumatic diseases is discussed as regards the linguistic and characterizing suitability of current or recommended terminology.

Rheumatic Diseases↗
PubMed1975

[Steroid saving effect of naproxen].

Since for various reasons the Lansbury Index appeared inadequate to define the therapeutic efficacy of antirheumatic compounds, we chose to investigate in our trials the prednisolone saving effect in patients with rheumatoid arthritis. Our investigations with the new antirheumatic substance d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) in most cases showed a prednisolone saving effect of 5 mg/day with a naproxen dose of 750 mg daily. In cases where a daily dose of 10 mg of prednisolone was necessary, a saving of 7.5 mg up to 10 mg was registered. But there were also failures and lesser saving effects. The steroid saving effect differs from one individual to another. In an additional study naproxen in a daily dose of 500 mg was compared with other antirheumatic agents (indometacin, azapropazon, and nifluminic acid) in patients not requiring steroids. The results were not uniform. In some cases naproxen was more effective, in other cases the substances mentioned were better. In these series joint function and subjective changes only were evaluated. Apart from a few cases of gastrointestinal side effects the drug was well tolerated.

Arthritis, Rheumatoid↗
PubMed1975

[Differential indications in rheumatism therapy on the basis of well-known drug side effects].

Special effects and side effects of antirheumatic basic treatment and symptomatic drugs, lead to distinct indications in the management of rheumatic diseases. Chloroquine should mainly be administered in "lupoid" rheumatoid arthritis (R.A.), in systemic lupus erythematosus, and in less active initial stages of R.A., whereas gold and D-penicillamine should be used in more active early stages of R.A. In psoriatic arthritis there is no contraindication for gold D-penicillamine, however, is less effective. Immunosuppressive agents may be used in special cases of R.A. and connective tissude diseases. However, strict controls and special care are necessary. Additive organ disorders may lead to individual contra-indications for basic treatment. All these drugs are not harmless and need careful control. In "lupoid" R.A. corticoids are superior to nonsteroidal antirheumatic drugs. The association of the conversion of R.A. into necrotizing vasculitis has been suggested. There is, however, no proof for this assertion. The new nonsteroidal antirheumatic drugs are assumed to have less side effects, but their real position may be evaluated only after much longer periods of administration. Rare, but severe side effects, especially due to the hematopoetic system, are problbly caused by an incompatibility of the patient. One must not forget the advantages for millions of rheumatic patients. Also, in an age of an exaggerated desire for security, special consideration must be given to these advantages, so that the development of new antirheumatic drugs is not suppressed.

Arthritis, Rheumatoid↗