PubMed Health⌕ Search

Biomedical subjects

H Mathies

Publications and source records attributed to H Mathies.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Investigations on the clinical effect of the antirheumatic agent piroxicam (author's transl)].

In the glucocorticoid-sparing test, which shows certain advantages compared with other experimental procedures, the clinical efficacy of the new antirheumatic substance piroxicam (Feldene) was investigated. It was shown that a single daily dose of 20 mg piroxicam gave at least an equal, if not better, effect compared with other substances tested earlier, as far as comparison is permissible between two collectives treated with different substance. The mean saving of prednisone was 5.7 mg/day and according to another evaluation 64.7% of the previously required dose of prednisolone. It is worth noting that owing to the long half-life there is a remarkable clinical effect over at least 24 hours with a single daily dose. Tolerance was good. Pathological laboratory values which were definitely to be attributed to the preparation were not seen in a trial period of a maximum of four weeks.

Anti-Inflammatory Agents↗
PubMed1980

[Study of the dose-reducing effect of acemetacin on prednisolon (author's transl)].

The dose-reducing effect of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy[ acetic acid (acemetacin, TV 1322, Rantudil¿) on prednisolon was studied on 22 patients suffering from rheumatoid arthritis. The average prednisolon-saving was 4.33 mg; in 31.8% of the patients it was possible to dispense with prednisolon completely (in 6 cases the reduction was 5 mg and in 1 case 7.5 mg). During the short test period the medication was well tolerated. Undesired gastro-intestinal drug reactions were not recorded for any of the patients. None of the investigated laboratory parameters revealed any pathological changes which were attributable to Acemetacin, but in one patient getting a long-term treatment with gold a decrease of lymphoid cell count was observed.

Adult↗
PubMed1979

[Azathioprine in rheumatology].

The indication for azathioprine (Imurek) has to be strictly adjusted, but amongst the immunosuppresive drugs it is without doubt the best tolerated substance and--provided that regular controls are carried out--is therefore also suitable for long-term treatment in practice.

Arthritis, Rheumatoid↗