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Biomedical subjects

H Meffert

Publications and source records attributed to H Meffert.

At least 127 records · Page 7Linked to original sources
PubMed1979

[New studies on the pathogenesis of lupus erythematosus].

The pathogenesis of the lupus erythematosus results from co-operation of three principles: (1) genetical disposition, (2) increased reactivity of the immune system, (3) different exogenic influences. The genetical disposition is confirmed by family investigations, metabolic disorders and immune anomalies as well as by parallels to animal models. The reaction manner of the immune system is genetically determined. Exogenic factors influence the immune system (behaviour) either as starter or by modifying the genetical material. The most striking humoral immune phenomenon is an immense number of (auto-)antibodies. Investigations of xeroderma pigmentosum as well as with DNA of different antigenity have shown that an increase of the antigenicity is unlikely for this phenomenon. In the serum of patients there were established and partially characterized factors (mitogens, granulocytic adherence-factor) for increasing the immune reactivity. The increase of such factors may be the sequence of a T-suppressor cell-defect. Like-wise no interdigitating cells in systemic lupus erythematosus have been found, cells which may be responsible for the terminal differentiation of T-lymphocytes. The mode of action of exogenic factors is represented and discussed with the example of the UV provocation.

Antibodies↗
PubMed1978

Increased immune response in the acute phase of systemic lupus erythematosus and psoriatic arthritis caused by serum factors.

In the acute phase of systemic lupus erythematosus the serum contains factors, with molecular weights ranging from 780,000 daltons to 1.5 million daltons, which induce blast transformation of autologous lymphocytes. In addition to the high-molecular weight components, low-molecular weight factors (75,000 and 160,000 daltons) which also induce an increase in lymphocytic transformation have also been demonstrated. In contrast to the high-molecular weight components the low-molecular factors stimulate the transformation of autologous and homologous lymphocytes. During transformation, lysis of autologous target fibroblasts occurs. The low-molecular weight mitogenic components remain stable after 30 min at 56 degrees C. The significance of such mediators for the pathogenesis of systemic lupus erythematosus is discussed.

Antibodies, Antinuclear↗
PubMed1977

[Lupus erythematodes visceralis and age (part II) (author's transl)].

The authors investigated: 1. The rheumatic status and the joint participation in lupus erythematodes visceralis in several age-groups. 2. The myocard-reactive antibodies in lupus erythematodes visceralis and in ischaemic heart diseases. 3. The antistreptolysine liter in lupus erythematodes visceralis. 4. The border cell antibodies in lupus erythematodes visceralis and "non-collagenosis" diseases. 5. The DNA-antibodies in lupus erythematodes visceralis and in normal persons.

Adolescent↗