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Biomedical subjects

H Meffert

Publications and source records attributed to H Meffert.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Radioimmunological detection of soluble immune complexes in serum (author's transl)].

Immune complexes could be measured in sera with the use of plastfixed Clq and 125J-labeled anti-Ig-antibody. The sensitivity of the system is 0.1 microgram aggregated human IgG, the working range is between 0.1 and 10 micrograms per 0.5 ml. In 58% of the sera from patients with systemic lupus erythematosus was found an increase in the immune complex content.

Antibodies, Anti-Idiotypic↗
PubMed1979

[Psoriasis vulgaris: immunologlobulin binding to human epidermis after limited proteolysis].

Immune complexes isolated from sera of psoriatic patients and healthy controls show an identical pattern in sodiumdodecylsulfate polyacrylamide gel electrophoresis. And so it seems to be unlikely that the increased provable serum immune complexes by psoriatics contain specific protein antigens.--Following to limited proteolysis of normal human epidermis, antibodies which solely are provable in sera of psoriatic patients could bind to proteolytic altered structures. For achieving a similar process in vivo, the following conditions are to be discussed: (1) an elevated concentration of certain autoantibodies in the sera of psoriatic patients and a temporary increased vessels permeability for antibodies, (2) the availability of structures in the epidermis of psoriatics with increased affintiy to certain antibodies. These structures may be produced by limited proteolysis or as a result of the disturbed differentiation of epidermal cells.

Antigen-Antibody Complex↗
PubMed1979

[Psoriasis vulgaris--decrease of serum immune complexes following photochemotherapy (author's transl)].

By means of a polyethylene glycol precipitate method [6] circulating immune complexes were examinated in increased concentration in 56 percent of the sera from psoriatic patients. The effect of photochemotherapy with external administration of 8-methoxypsoralen followed by irradiation with UVA was investigated. In 12 of 13 cases the serum immune complex concentration after the therapy was normal.

Antigen-Antibody Complex↗