Biomedical subjects

H Menke

Publications and source records attributed to H Menke.

58 records · Page 4Linked to original sources

PubMedDate not supplied

PVP breast implants after two years: initial results of a prospective study.

A prospective study of a new mammary prosthesis with PVP-based gel as filling material was carried out. Scheduled follow-ups were planned at 3, 6, 12, and 24 months post-implantation to assess all complications, Baker scores, and the patient's, and the physician's global assessment of each implant. PVP-filled implants were used in 95 breasts for augmentation (60%) or reconstruction (40%). Sixty-nine percent of all patients underwent a primary procedure, 19% had a history of severe capsular fibrosis. During follow-up, a hematoma was observed in 2% and a seroma in 5%. Leakage occurred in 3% (one iatrogenic and two cases of unknown reason), a Baker 3 in 6% (12 months). No volume increase of the implants occurred. The probability that a patient would be complication-free at 24 months was 0.86. Physician's and patient's satisfaction rating after 12 months remained high without any time effect (physician very good/good 63%, patient 75%). According to our current experiences, the PVP-filled implants are a remarkable alternative with an improved viscosity and enhanced x-ray transmission, compared to saline filled implants.

Adolescent↗

PubMedDate not supplied

Successful surgery of multiple recurrent basal cell carcinomas guided by photodynamic diagnosis.

We describe a 56-year-old Caucasian man with history of multiple regressed basal cell carcinomas. During the last 20 years approximately 200 histologically proven basal cell carcinomas preferentially localized on the face were surgically treated. Several large skin grafts were necessary to cover the extensive tissue defects on the face and scalp. Although all excised tissues were histologically proven to be basal cell carcinomas with tumor-free margins, new tumors developed in proximity to the skin graft margins. The dissemination of the new tumors made it difficult to perform additional invasive operation procedures without influencing the cosmetic result. Thus, we used photodynamic diagnosis to improve detection and demarcation of the neoplastic tissues. This procedure facilitated surgical planning and enabled primary in toto excisions. Surgical trauma and a number of interventions were thus minimized with the consequence of improved cosmetic and functional results.

Aminolevulinic Acid↗

PubMedDate not supplied

Formation of ssb, dsb, and uracil in monofilarly and bifilarly bromouracil-substituted DNA molecules.

Bifilarly BU-substituted ColE 1 plasmid and monofilarly BU-substituted M 13 phage DNA were irradiated with UV light of 313 nm. Using agarose gel electrophoresis and "reversed phase" HPLC technique ssb, dsb induction and uracil formation, respectively, could be detected in the irradiated DNA in dependence on the UV fluence. The analysis of the strandbreaks in bifilar ColE 1 DNA shows a significant part of directly induced dsb. Cross sections of ssb induction from 4.1 m2/J x 10(7) in 28%, 3.9 m2/J x 10(7) in 55% and 3.1 m2/J x 10(7) in 85-90% BU-substituted DNA were calculated. The cross section for dsb induction was found to be 0.04 m2/J x 10(7), estimated from the linear part of the fluence effect curve. In monofilar M 13 DNA a linear fluence effect curve for dsb induction was obtained. Excluding other than the direct production of dsb by using an in vitro approach for M 13 DNA, the results strongly support the hypothesis that dsb can be induced by one photochemical absorption event. The cross section for ssb was 3.8 m2/J x 10(7) and for dsb 0.05 m2/J x 10(7) in 41.5% monofilarly BU-substituted M 13 DNA. The comparison of ssb, dsb, and uracil production in bifilar and monofilar DNA with similar BU substitution showed no significant difference between the two DNA systems (ColE 1, M 13), indicating that the location of BU molecules in one or in both DNA strands will not lead to a different number of lesions after UV313 exposure.

Bromouracil↗

PubMedDate not supplied

Predictive value of ASA classification for the assessment of the perioperative risk.

To assess the predictive value of the ASA classification for morbidity and mortality during the whole time of post-operative hospitalization, data of 2248 patients undergoing elective surgery were analyzed prospectively. The incidence of post-operative morbidity, considering surgical as well as non-surgical complications, rose from 3.9% in ASA class I to 33.7% in ASA class IV. No patient died in ASA I, whereas 7.2% died in ASA IV. Furthermore, the ASA classes corresponded with the postoperative outcome of the patients, taking into account both the length of stay at the ICU and the postoperative hospitalization. The duration at the ICU increased an average of 0.1 to nearly 4 days and hospitalization from 11.8 to 27.3 in ASA classes I and IV, respectively. The results were confirmed considering separated groups with a different operative stress and risk. ASA-classification is also of conceivable value in estimating the perioperative risk and should therefore be considered prior to surgical intervention.

Adult↗