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Biomedical subjects

H N Minh

Publications and source records attributed to H N Minh.

At least 19 recordsLinked to original sources
PubMed1996

[Reccurent abortions: unpublished syndrome suggesting the explanation of fetal death].

A report is given of 8 cases of recurrent "idiopathic" abortions sharing in common the following features, unreported so far: (1) high uterine arterial impedance; (2) decrease in endometrial thickness, in spite of normal hormonal and endometrial cycle at biopsy; (3) a history of previous curettages. Such a syndrome could be consistent with the existence of a narrow peripheral symphysis of the uterine cavity, unaffecting its shape at hysterography.

Abortion, Habitual↗
PubMed1995

[Micro-invasive cancer of the uterine cervix].

There is no current international consensus on the classification of microcarcinomas. There is still controversy over the depth of the stroma invasion and lymph node invasion as well as on confluence of invasive spread. The FIGO classification has been used since 1985 in which microinvasive carcinomas are considered as infraclinical cancers forming a group classed as stage 1a and divided into subgroups: 1a1 = early invasion of the stroma < 1 mm in depth; 1a2 = microinvasive carcinoma with invasion < 5 mm and width < 7 mm. Two important practical points must be added to this classification: demonstration of emboli via lymphatic or blood stream dissemination. Microinvasive carcinoma is demonstrated on conization specimens obtained after guided biopsy revealed intraepithelial neoplasia. Treatment can be standardized on the basis of the pathology report on the conization specimen.

Female↗
PubMed1995

[Classification of ovarian tumors based on embryogenesis].

This paper studies gonadal differentiation into the ovary from the earliest interaction between germ cells and somatic cells in the developing urogenital ridge up to the formation of primordial follicles. Granulosa cells appear to be derived from the breaking down of the cordlike arrangement of epithelial cells resulting from proliferation of surface coelomic mesothelium. Thecal cells arise from mesenchymal progenitors cells in the ovarian stroma. Based on the findings of embryology and biology, the authors then propose a classification of ovarian tumors by rearranging the WHO classification.

Carcinoma↗
PubMed1993

[Female pseudohermaphroditism].

Contrary to what is observed in true hermaphroditism and in male pseudo-hermaphroditism, there is no erroneous transmission of the genetic gonadal differentiation programme in female pseudohermaphroditism. All that has happened is virilization of the urogenital sinus and external genitalia in a foetus exposed to exo- or endogenous androgens. In the absence of testis there is no production of anti-mullerian hormone, and for these reasons the uterus, the fallopian tubes and the vagina develop normally, whilst the wollfian ducts are regressed and there is no trace of male deep spermatic pathway. On the basis of recent acquisitions in biochemistry, endocrinology and embryogenesis, the authors compare the various degrees of virilization with the biochemical abnormalities.

3-Hydroxysteroid Dehydrogenases↗
PubMed1993

[From embryogenesis to pathogenesis of effects of diethylstilbestrol on the female genital tract].

From studies on embryogenesis, the authors describe the development, not conditioned by sex steroids, of the upper female genital tract and, in particular, the formation of its cervico-vaginal portion and the shaping of the uterine cervix in about the 16th week of pregnancy. Basing themselves on the physiology of the foeto-placental unit and on the hormonal profile of the foetal ovary, they show that the action of oestrogens on the foetal uterine cervix can be observed only from the 32nd week onward. The action of diethylstilboestrol--a potent oestrogen that is not steroidal and therefore not degraded by foetal metabolism--on the foetal genital tract is explained. An excessive development of the uterine canal caudal part determines structural anomalies of the uterine cervix at birth, the T shape of the uterine cavity and the vaginal diaphragms. The aetiogenesis of clear-cell adenocarcinoma in the cervico-vaginal portion is discussed.

Diethylstilbestrol↗
PubMed1992

[Hermaphroditism and male pseudohermaphroditism].

In the human embryo, sex is all in the genes. Later on, the male and female sexual characters, which are products of the expression of all individual genomes, differentiate men from women. In this paper, the embryogenesis and morphology of true hermaphroditism and male pseudo-hermaphroditism are studied. These are intersexual states determined by errors in genital programme transmission. A relationship is established between the biochemical identification of substances secreted by the testis and the evolution of sexual characters. The genesis of sexual abnormalities according to the stage when the testicular deficit appears is envisaged. The clinical, anatomical, histological and biochemical aspects of these intersexual states are described.

3-Hydroxysteroid Dehydrogenases↗
PubMed1992

[Histogenesis of isthmic nodular salpingitis].

Nodular salpingitis of the isthmus is a clinicopathological entity related to what is classically referred to as interstitial adenomyosis. These two lesions are due to the same aetiopathogenic process and result from inflammatory proliferation of the tubal epithelium with formation of pseudoglandular ducts. The only difference between the two is that one is ensheathed by a fine network of mesonephric muscle fibres and the other is surrounded by a thick layer of myometrial muscle fibres. These two lesions should be grouped under the same heading: nodular salpingitis. The term adenomyosis is incorrect due to the absence of endometrial glandular ducts and stroma in these lesions. Nodular salpingitis of the isthmus should be distinguished from tubal endometriosis, which is part of the clinical expression of extrauterine endometriosis. In particular, this lesion must be distinguished from interstitial endometriosis which, for some authors, corresponds to colonisation of the tubal mucosa by endometrium and, for others, to metaplasia of the tubal mucosa.

Diagnosis, Differential↗
PubMed1990

[A case of pflügeroma or mixed germ cell-sex cord stroma tumor].

We report a case of pflügerome, a tumor now designated by the term "mixed germ cell sex cord and stroma tumor". This infrequent tumor consists in a proliferation of germ cells surrounded by Sertoli-granulosa-type cells and arises in patients with a feminine phenotype and a 46XY karyotype; it should be differentiated from gonadoblastomas that are seen in patients with a female phenotype and a 46XY or 46XX/46XY mosaic karyotype. Prognosis is good and recovery occurs following exeresis. On the basis of their studies on gonadal differentiation in human embryos, the authors propose the following terms: "tumors of the gonadal anlage with male differenciation" for gonadoblastomas, "tumors of the gonadal anlage with female differentiation" for pflügeromes.

Cell Differentiation↗
PubMed1986

[An integrated histogenetic concept of internal and external endometriosis].

The authors have studied the embryology of the uterus and have studied the comparative morphology of the internal foci of endometriosis, as well as the endometrium itself during the menstrual cycle. These studies have led them to think that the foci of endometriosis, whether they are internal or external, come from cells of coelomic mesothelium that persists in the transitional zone between the myometrium and the endometrium of the uterus, or in the mesothelium that covers the ovary, the tube and the pelvis under the stimulus of substances that are present in degenerate endometrial tissues during menstruation. This unitary idea of histogenesis makes it possible to consider under one heading, if not to unite, all endometriosis occurring anywhere according to their histogenic presentation under the same conditions of the tissues that surround them. It also makes it possible to explain the morphological similarity of endometriosis with the endometrium, although the biological behaviour of the two tissues is different. There is therefore a relationship between endometrium and endometriosis but not a filial one.

Endometriosis↗
PubMed1984

Morphological study of the chorio-allantoic fetal membranes.

Morphological study of the chorio-allantoic fetal membranes has demonstrated the existence of foot processes extending from the main body of amniotic cells and containing microfibrils arranged in dense bundles as described in podocytes of renal glomerulae; on the surface fronds and between their bases many small pits and caveolae are seen; in the cytoplasm of amniotic cells large vacuoles are present; they frequently distort the nuclei into crescentic shapes. In the chorion underlying the amnios, fibroblasts and Hofbauer cells are found; their surface often has overlapping filopidal projections. The syncytium bounding the intervillous space shows a marked resemblance to that of the villi. These morphological features seem to indicate that chorio-allantoic fetal membranes might be an important route for the transporting of fluid from the maternal blood in the intervillous space into the amniotic compartment.

Allantois↗
PubMed1984

[New data on the morphology of the allanto-chorion fetal membranes].

The authors have carried out an electron microscopic study on the morphology of the allanto-chorial membranes of late pregnancy. The demonstration of these amniotic cells with their long pedicles which resemble those of renal podocytes, together with the presence of intercellular canals lined by long villi which themselves cross over with one another to make a grid, and the existence of intracellular canals that make transcytoplasmic tunnels, permit the authors to suggest that they are dealing with a morphological illustration of ultrafiltration processes. The authors suggest that the forces that bring about plasma filtration from the intervillous chamber towards the amniotic compartment crossing the allanto-chorial membranes are the same as those that cause glomerular filtration. These are hydrostatic pressure in the intervillous chamber and the oncotic pressure within the amniotic compartment.

Allantois↗
PubMed1983

[Reabsorption of amniotic fluid through parietal fetal membranes. A hypothesis based on an ultrastructure study].

Recent investigations have shown that the link between water transport and solute transport in epithelia is made possible by subcellular structure build on a striking geometrical plan, namely, long and narrow dead end channels. The most striking feature of our electron microscopic study of the amnion as well as the chorionic cytotrophoblast, was the demonstration of the existence of intercellular channels running between the lateral sides of the cells with typical junctional complexes sealing their proximal ends; thus they constitute long and narrow dead-end channels. In the amnion, these channels open through the basal lamina into the connective tissue, and in the chorionic cytotrophoblast they open in the direction of the decidua. This situation seems to indicate that fluid emerges from the open mouth of the amniotic intercellular channels and then continues to flow into the channels of the cytotrophoblast, across its podocytic processes, to be dumped into the decidua, and finally drained by maternal decidual vessels. This morphological study suggests that parietal fetal membranes might be an important route for transport of solute and fluid from the liquor amnii into the maternal circulation.

Absorption↗
PubMed1982

["Vestigial cells" of the transitional area of the uterine-cervix. Comparative morphological study with the subcylindrical-reserve-cells (author's transl)].

The squamo-cylindrical junction represents a transitional area of unstable epithelium. It consists of slightly differentiated cells which disclosed resemblance in morphological pattern with germinal cells of the basal layer in the exocervical squamous epithelium. These unstable cells, according to the authors, may be derived from the cranial, most cephalic extend of the sinusal vaginal plate which had formed the epithelium of the entire vagina and the vaginal portion of the cervix up to the squamo-columnar junction. Ultrastructural analysis disclosed no similarities between cells of the squamo-columnar junction and subcylindrical reserve cells which exhibited sometimes resemblance to the "mesenchymal cells" found within the surrounding stroma.

Cervix Uteri↗
PubMed1981

A hypothesis on the origin of the subcylindrical reserve cells of the endocervix.

The structural features of subcylindrical reserve cells of the endocervix are presented. Reserve cells varied in shape. They were randomly oriented and most had a bean-like or spindle shape. Some were loosely apposed with no desmosomes while others were separated by an intercellular matrix. Their nuclei were oval or fusiform, with a prominent nucleolus. Coarse chromatin plaques are distributed irregularly within the nuclei, and surface membrane showed cytoplasmic projections. Within the connective tissue, close to the basal membrane, could be found cells that showed the same structural features; some of them were partially enveloped by amorphous ground substance and collagen, and had small processes extending from the cell surface in the direction of the epithelial layer. Ultrastructural analysis of these cells disclosed some similarities with fibroblasts in the surrounding stroma, and suggested that they were primitive mesenchymal cells originating from Müllerian mesenchyme.

Cell Nucleolus↗
PubMed1980

Fetal membrane morphology and circulation of the liquor amnii.

Morphological study of the human fetal membranes (at the term of pregnancy) shows that under the amniochorion lies the chorionic cytophoblast, which completely surrounds the amniotic cavity. Chorionic cytotrophoblast as well as parietal decidua persist until full term and remain well-developed. Within trophoblastic cells there are numerous canalicular formations bordered by microvilli resembling those observed between amniotic cells. The authors therefore believe that the circulation of amniotic fluid, after traversing the amnion, will continue through the intercellular canaliculi of the chorionic cytotrophoblast to reach the decidua parietalis. All the components of this complex membrane must play a part in the amniotic fluid circulation.

Amnion↗