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Biomedical subjects

H N Minh

Publications and source records attributed to H N Minh.

At least 37 records · Page 2Linked to original sources
PubMed1978

[The histogenetic significance of dysplastic lesions of the cervix (author's transl)].

From the morphological studies that they have carried out the authors describe dysplasias of the cervix of the uterus as a collection of lesions developed from the vestigial cells which are situated at the endo-exocervical junction. The embryological origin of this junction is the sinus. These dysplasias consist of cells with basophil cytoplasm with edges that are not sharp. These form streams which run from the external os of the cervix towards the endocervix, where they replace and disturb the cylindrical epithelium wherever they meet it. These lesions may take on two forms: regular or irregular according to the degree of nucleo-cytoplasmic disharmony. The slow and insidious evolution of these lesions must be distinguished from dystrophic endocervical lesions which are caused by a disturbance in the nutrition of the tissues, which itself is of hormonal or inflammatory origin, and from exocervical lesions which, in common with all lesions of the malpighian mucosa, can undergo atypical scarring.

Cell Nucleus↗
PubMed1978

[The dynamics of the amniotic fluid].

Morphological study of the ovular membranes showing that under the amnion, until term, there persists perfectly live and active chorial cytotrophoblast covered by a well vascularised and developed parietal decidua. Under the electron microscopy, the apical pole of the amniotic cells as well as their intercellular space are bordered by microvilli. Their basal pole has squat pedicels. The chorion which supports the amnion is avascular. The surface of the cytotrophoblast opposite the chorio-amnion is raised by numerous protuberances in the form of pedicels. The trophoblast is also furrowed by intercellular canals bordered by microvilli and reinforced by desmosomes. Two cellular appearances may be distinguished in the trophoblast: elements similar to the syncytial type with the characteristics of steroid cells and elements of a Langhans type which may play a role in protein synthesis. The decidual cells, in a quinconcial perivascular arrangement, are rich in pinocytotic vesicles. Thus whilst it is undeniable that the foetus plays a certain role in the dynamics of the amniotic fluid by swallowing and urinary excretion, these phenomena are minimal in relation to exchanges through the ovular membranes. Transamniotic passage is the first stage in movement of the fluid. The chorion, by virtue of its plexiform, areolar structure forms the next stop. From the chorion, the circulation continues through the intercellular canals of the trophoblast and the amniotic fluid is thus brought into the well vascularised parietal decidua. In addition to this extracellular circulation, the authors fell that there exists an intracellular passage by uptake and secretion, as evidenced by the high degree of pinocytosis within the cells.

Amnion↗
PubMedDate not supplied

[Vascular lesions of the endometrium in spontaneous abortion].

On the basis of a histological study of vascular lesions of the endometrium following 108 cases of spontaneous abortion, the authors propose the following conclusions: 1) In the first six weeks of pregnancy, early abortion results more often from a primary ovular defect than from any abnormality in the maternal environment, of endogenous or exogenous origin and capable of resulting in a lesion of the endometrium or its vascularisation. The structure of the walls of the spiral arteries of pregnancy is almost invariably normal. 2) By contrast, in late abortions, arterial lesions--and in particular fibrosis--may play a role. This occurs however when the basal arteries with a well-differentiated elastic structure are involved. The spiral arteries of pregnancy and the utero-placentar arteries are involved only by lesions of vasculitis secondary to inflammatory phenomena as a result of retention of the products of conception or by pseudo-atheromatous lesions resulting from the deposition of degenerated cyto-trophoblastic elements, but never from true arteriosclerotic lesions.

Abortion, Spontaneous↗
PubMedDate not supplied

[Morphogenesis of vaginal aplasia. Therapeutic deductions].

On the basis of the studies of the embryogenesis of the vagina, the authors consider that malformations classically described as being partial aplasia should not be separated from the total absence of the vagina. The important feature is the association of a functioning or non functioning uterus with the absence of the vagina. They believe that it is incorrect to describe the pouch of menstrual retention associated with a functioning uterus as "haematocolpos" and that is not justified to describe the cup-shaped vestibular depression as "hemi-vagina". According to the authors, although vaginal aplasia with a functioning uterus forming a pouch of menstrual retention constitutes an absolute indication for surgery, surgery is not justified in cases of vaginal aplasia with a non functioning uterus. If Frank's method fails in these cases, the patient or the couple should be referred to a sexologist, as women with this anomaly retain a perfect femininity, although unable to conceive.

Abnormalities, Multiple↗