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Biomedical subjects

H Newmark

Publications and source records attributed to H Newmark.

At least 55 records · Page 3Linked to original sources
PubMed1986

Primary leiomyosarcoma of gallbladder seen on computed tomography and ultrasound.

Neoplasms of the gallbladder are relatively rare and their preoperative diagnosis that much rarer; leiomyosarcoma of the gallbladder is one of the most infrequent types. The authors had the opportunity to diagnose such a neoplasm preoperatively (although the histological diagnosis was not made). The ultrasound and computed tomographic appearance has not been published before. Leiomyosarcoma showed a dilated gallbladder with an irregularly thickened wall and a polypoid protrusion into the lumen.

Aged↗
PubMed1985

Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer.

We studied the frequency and distribution of proliferating epithelial cells lining colonic crypts in 10 subjects at high risk for familial colonic cancer, before and after oral supplementation of their conventional diets with 1.25 g of calcium as calcium carbonate. Patterns of cell proliferation were defined by dividing the colonic crypt into longitudinal compartments and comparing the numbers and fractions of tritiated thymidine--labeled epithelial cells in the various compartments. Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the colonic crypts was comparable to that previously observed in subjects who had had familial colonic cancer. Two to three months after supplementation had been started, proliferation was significantly reduced and the profile of the colonic crypts approached that previously observed in subjects at low risk for colonic cancer. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the colonic mucosa of subjects at high risk of colon cancer, similar to that observed in subjects at low risk.

Calcium, Dietary↗
PubMed1985

Oral beta-carotene can increase the number of OKT4+ cells in human blood.

Oral doses of beta-carotene (180 mg/day) given for 2 wk to normal human volunteers significantly increased the frequency of OKT4+ (helper/inducer T cells) after 7 days and of OKT3+ (all T cells) after 14 days. The frequency of OKT8+ cells was unaffected, as compared to untreated controls. Plasma levels of beta-carotene were markedly elevated throughout the study. Plasma levels of vitamin A were slightly (but significantly) elevated on days 7 and 14. No toxicity was observed. Oral beta-carotene treatment may be a clinically effective means of enhancing T4+ lymphocytes.

Adult↗
PubMed1984

Caffeic and ferulic acid as blockers of nitrosamine formation.

Caffeic acid and ferulic acid, which are naturally occurring phenols present in a wide variety of plants, were examined for their ability to react with nitrite in vitro and to inhibit nitrosamine formation in vivo. Their activities were compared with other phenols (butylated hydroxyanisole and Trolox) and with a non-phenolic polyhydroxylated compound, glycerol guaiacolate. In simulated gastric fluid, caffeic acid and ferulic acid reacted rapidly and completely with an equimolar quantity of sodium nitrite. In rats receiving aminopyrine and nitrite, caffeic acid and ferulic acid blocked the elevation of serum N-nitrosodimethylamine (NDMA) levels and the serum glutamic pyruvic transaminase levels associated with hepatotoxicity. Neither phenol had any effect on serum levels of NDMA in rats treated with NDMA. In both the in vitro (reaction with nitrite) and in vivo (inhibition of hepatotoxicity) systems, caffeic acid was more effective than ferulic acid. Butylated hydroxyanisole and Trolox were partially effective, and glycerol guaiacolate was inactive. The results of this study suggest that dietary caffeic acid and ferulic acid may play a role in the body's defense against carcinogenesis by inhibiting the formation of N-nitroso compounds.

Alanine Transaminase↗
PubMed1982

Computerized tomography and adenocarcinoma of the esophagus.

A case of adenocarcinoma of the stomach spreading to the esophagus is described. It was well seen on computerized tomography and appeared more ominous than the esophagram. The latter illustrated an appearance simulating narrowing secondary to peptic esophagitis; the former demonstrated a relatively large encompassing mass. The definitive diagnosis was made during endoscopy and confirmed by biopsy. Although computerized tomography is not considered the method of choice for establishing an abnormality in this organ, it can occasionally help. It can usually show the total extent of the tumor better. Additional cases are presented.

Adenocarcinoma↗
PubMed1981

The recurrent varicocele--a poorly recognized problem.

A varicocele is most likely the result of an incompetent vein with retrograde flow of blood into the scrotum. Surgical ligation of this incompetent system is the present-day procedure of choice. In our series of 225 varicocelectomies, there have been three definite recurrences, due to either recollateralization or failure to ligate all branches of this venous plexus.

Arteries↗
PubMed1981

Bleeding peptic ulcer caused by ectopic gastric mucosa in a duplicated segment of jejunum.

The authors present a case in which a patient suffered a bleeding jejunal ulcer caused by heterotopic gastric mucosa in a congenital duplication of a segment of jejunum. This is the first case diagnosed preoperatively by two different radiographic means. These lesions were shown by both pertechnetate flow and barium small bowel studies. The rarity of these entities and the modalities used for diagnosis are described.

Adult↗
PubMed1979

Noncalcified echinococcal liver cyst.

A large echinococcal cyst containing clear fluid was seen as a lucent defect within the liver on the plain radiograph. It had no fatty or calcific contents. No similar cases could be found in the literature.

Adult↗
PubMed1978

Case report: echinococcal cyst of the liver seen on computed tomography.

A case of a single, large noncalcified echinococcal cyst of the liver demonstrated by computed tomography (CT) and verified at surgery is presented. To our knowledge, no previous CT pictorial display of such a lesion has been reported in the literature. The cyst appears as a radiolucent, sharply demarcated lesion of water density.

Echinococcosis, Hepatic↗
PubMed1978

Calcific tendinitis of the neck.

When a calcific deposit in the shoulder, hip or elbow ruptures, it results in severe pain and tenderness. Few clinicians are aware that the longus colli muscle of the neck is also subject to acute tendinitis. When it occurs, the pain and spasm mimic infectious spondylitis or meningitis. Four patients are presented with acute tendinitis of the longus colli muscle and the classic radiographic findings of soft-tissue swelling and amorphous calcium deposits in the tendon.

Adult↗