Biomedical subjects
Publications and source records attributed to H Newmark.
A case of primary carcinoma of the gallbladder with nodal metastases, diagnosed by ultrasound examination in a nonjaundiced patient, is described. The gallbladder mass was also visualized on oral cholecystography. The ultrasonic and pathologic findings are correlated.
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CONTEXT: Before the development of human colonic neoplasms, colonic epithelial cells showed altered growth and differentiation. These alterations characterized mucosa at risk for cancer formation and were termed intermediate biomarkers of risk. Modifications of the mucosa toward more normal features by nutrients or drugs are putative approaches to chemoprevention of colon cancer. OBJECTIVE: To determine whether increasing calcium intake via dairy products alters colonic biomarkers toward normal. DESIGN: Randomized, single-blind, controlled study. SETTING: Outpatient clinic. PARTICIPANTS: Seventy subjects with a history of polypectomy for colonic adenomatous polyps. INTERVENTION: Low-fat dairy products containing up to 1200 mg/d of calcium. Subjects were randomized to 4 strata by diet (control vs higher calcium) and age (<60 vs > or = 60 years). MAIN OUTCOME MEASURES: Changes in total colonic epithelial cells and number and position of thymidine-labeled epithelial cells and changes in the ratio of sulfomucins (predominantly secreted by distal colorectal epithelial cells) to sialomucins and expression of cytokeratin AE1, 2 markers of colonic cell differentiation. RESULTS: During 6 and 12 months of treatment, reduction of colonic epithelial cell proliferative activity (P<.05), reduction in size of the proliferative compartment (P<.05), and restoration of acidic mucin (P<.02), cytokeratin AE1 distribution (P<.05), and nuclear size (P<.05) toward that of normal cells occurred. Control subjects showed no differences from baseline proliferative values at 6 and 12 months (P>.05). CONCLUSION: Increasing the daily intake of calcium by up to 1200 mg via low-fat dairy food in subjects at risk for colonic neoplasia reduces proliferative activity of colonic epithelial cells and restores markers of normal cellular differentiation.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The author presents a case of Paget's disease effecting a lumbar vertebral body that was seen on a computerized tomogram. It had an interesting appearance and showed no contrast enhancement. There was a moderate compression fracture to this vertebral body and there was encroachment on the spinal canal. The author knows of no other similar case presentation.
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The authors present a case of Kartagener's syndrome that was seen on CT. To the authors' knowledge, this is the first reported case of such. The appearance and interesting aspects of the case will be described.
The authors report a rare case of an ovarian tumor metastasizing to the dura at L2-L3. It was seen at myelography to be intradural and by CT to be within the spinal canal. The latter exam eliminated a lipoma or a dermoid (both possible intradural or extramedullary-intradural tumor) from consideration.
The authors present the first case of a primary yolk sac tumor of the neck metastasizing to the spine, demonstrated by computed tomography. It caused a partial block.
A case is presented of a patient who had vas deferens calcification seen on an intravenous pyelogram and a computerized tomographic scan. The authors feel that the CT appearance has not been presented in the literature before.
The authors present three cases of cervical ribs discovered by computerized tomography (CT). This represents, to the authors' knowledge, the first such report. The radiologic appearance and relevant clinical findings of cervical ribs will be discussed.
A case of a large tonsillolith visualized by computerized tomography is presented. Although otolaryngologists are well aware of this entity, few radiologists are. The importance of distinguishing tonsilloliths from other structures by CT scan is discussed.