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Biomedical subjects

H O Perry

Publications and source records attributed to H O Perry.

At least 37 records · Page 2Linked to original sources
PubMed1985

Pyoderma gangrenosum: a review of 86 patients.

The clinical, histologic, and immunofluorescent findings in 86 cases of pyoderma gangrenosum seen at the Mayo Clinic between 1970 and 1983 were reviewed. Males and females were affected in equal numbers. The most frequent site of lesions was the leg. Sixty-seven patients (78 per cent) had associated systemic disease, with arthritis and inflammatory bowel disease being commonest. Cutaneous histopathologic changes varied with the site of biopsy. Lymphocytic vasculitis was predominant in the zone of erythema peripheral to the area of ulceration, while neutrophilic infiltrate and abscess formation were more prominent centrally. In most cases studied, direct immunofluorescence showed immunoglobulins and complement deposited in and around superficial and deep dermal vessels.

Adolescent↗
PubMed1985

Skin lesions from sun exposure: a treatment guide.

Leukoplakia is a clinical term that may histologically represent actinic changes or frank squamous cell carcinoma. Because the nature of dysplasia may differ in various portions of the involved lip, adequate histologic examination is mandatory. Histologic characteristics of squamous cell carcinoma include loss of cell organization and orientation, loss of intercellular bridges, presence of nuclear atypia and mitotic figures, and premature cell keratinization.

Acute Disease↗
PubMed1985

Differentiating seborrheic keratosis from skin neoplasm.

The pigmented acanthotic type of lesion may resemble malignant melanoma. When in doubt, a biopsy will usually resolve the question. Seborrheic keratoses may become irritated or inflamed after trauma, biopsy, or exposure to irritants, causing transformation of the basaloid cell type to squamous cells. Such changes may be misinterpreted as diagnostic of basal or squamous epithelioma.

Diagnosis, Differential↗
PubMed1984

Scleredema: a review of thirty-three cases.

A review of thirty-three cases of scleredema, with particular reference to clinical and histologic findings, revealed that the disease was often of insidious onset and the course was usually prolonged. A preceding respiratory tract infection was uncommon and usually did not indicate a short course. The patients were divided into two groups according to the presence or absence of diabetes. Diabetes, when present, was typically the late-onset, insulin-dependent type and difficult to control. In many of these patients, the onset of scleredema was so subtle that it went unnoticed by the patient until pointed out by an examining physician.

Adolescent↗
PubMed1984

Treatment of psoriasis with N-phosphonacetyl-L-aspartate.

Seven patients with severe psoriasis were treated with the aspartate carbamylase inhibitor N-phosphonacetyl-L-aspartate (PALA). Three patients showed a definite improvement lasting up to 3 months after each course of therapy. Three other patients showed more limited responses of shorter duration, and one patient experienced progressive worsening of his psoriasis while on the study. Psoriatic arthritis did not appear to be improved by the PALA therapy. Side effects were usually mild and limited to skin irritation and diarrhea. The development of alternate schedules of administration may lead to a more useful treatment response in patients with severe psoriasis.

Adult↗
PubMed1984

Olmsted syndrome--congenital palmoplantar and periorificial keratoderma.

We are reporting the third case of the Olmsted syndrome, an entity that has received little attention in the medical literature. The syndrome consists of congenital diffuse, sharply marginated keratoderma of the palms and soles, onychodystrophy , constrictions of digits, and periorificial keratoses. Our patient, in addition, had congenital universal alopecia, absence of a premolar tooth, leukokeratosis of oral tissue, and hyperlaxity of the joints. The differential diagnosis includes hidrotic ectodermal dysplasia of the Clouston type, pachyonychia congenita, acrodermatitis enteropathica, keratoma hereditarium mutilans of Vohwinkel , mal de Meleda , and other forms of palmoplantar keratodermas . This patient had originally been reported as having acrodermatitis enteropathica, a condition with which the Olmsted syndrome can easily be confused.

Adult↗
PubMed1984

Pemphigus vulgaris: results of treatment with gold as a steroid-sparing agent in a series of thirteen patients.

Between 1974 and 1981, thirteen patients with pemphigus vulgaris were treated with prednisone supplemented by gold salts. Therapy resulted in excellent responses in eleven of the thirteen, with complete remission in seven. At a mean follow-up of 48.8 months, five patients still had complete remission and required no further treatment. Treatment of pemphigus vulgaris initially with prednisone followed by gold compounds is recommended as an important modality with relatively low morbidity and may permit lower effective doses of corticosteroids to be employed, occasionally even permitting their complete withdrawal.

Adult↗
PubMed1984

Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride.

In a prospective, randomized, double-blind, placebo-controlled, cross-over study of forty-one patients we found that oral ingestion of 1,248 mg a day of L-Lysine monohydrochloride shows evidence of decreasing the recurrence rate of herpes simplex attacks in nonimmunocompromised hosts. A dose of 624 mg a day was not effective. L-Lysine may also be capable of decreasing the severity of symptoms associated with recurrences. Neither dosage showed any evidence of shortening the healing time compared to placebo.

Administration, Oral↗
PubMed1984

Secondary and tertiary syphilis presenting as sarcoidal reactions of the skin.

Secondary and tertiary skin lesions of syphilis are infrequently biopsied and studied histologically. Examination of biopsy specimens from two patients, one with secondary and one with tertiary syphilis, revealed sarcoidal reactions, which caused confusion in the patients' diagnoses. The response to penicillin therapy in each patient was dramatic and contrary to the response anticipated in sarcoidosis. The histologic changes of secondary and tertiary syphilis are discussed.

Adult↗
PubMed1984

Condyloma acuminatum in Rochester, Minn., 1950-1978. I. Epidemiology and clinical features.

From 1950 through 1978, condyloma acuminatum was diagnosed in 746 residents of Rochester, Minn (246 male and 500 female subjects). With the number of cases increasing almost every year until 1975, the mean annual incidence rate reached 106.5 per 100,000 population in the period 1975 through 1978, apparently the highest reported to date. Among age groups, the rate was highest in the 20- through 24-year-old group. Female patients contracted the infection at a higher rate and at a younger age than male patients. Anal condyloma occurred in one third of the male subjects studied and recurrent condyloma in 30% of the male subjects. More female than male patients had lesions at multiple locations.

Adolescent↗
PubMed1984

Condyloma acuminatum in Rochester, Minn, 1950-1978. II. Anaplasias and unfavorable outcomes.

A total of 746 patients residing in Rochester, Minn, received the diagnosis of condyloma acuminatum between 1950 and 1978. Anaplasia was present in six and subsequently developed in 36 patients during follow-up examination in 42 patients (one male and 41 female). One had invasive squamous cell carcinoma (vulva), six had severe dysplasias, 21 had moderate to mild dysplasias, and 14 had carcinomas in situ (CIS), of which 11 were cervical. In the female patients, 37 of the anaplasias were cervical and the other four were vulval or vaginal. The 11 cervical CIS amounted to 3.8 times the expected number of 2.9, based on an earlier study of cervical cancer incidence in the community. The risk of cervical CIS developing among patients with condyloma is significantly higher than expected. Neither laryngeal papilloma nor other unfavorable outcomes substantially affected the conceptus of 51 pregnancies in women with concurrent condyloma. There appears to be an association between condyloma and genital malignant neoplasms and a relationship of condyloma with sexually transmitted disease and warts.

Anaplasia↗
PubMed1984

Pyoderma gangrenosum in childhood.

A review of our records disclosed eight children with pyoderma gangrenosum. All had associated inflammatory bowel disease, and four had arthritis. In three patients the bowel disease was severe and required resection of portions of the affected bowel. The cutaneous lesions had a chronic course (average duration, 2 1/2 years), and systemic therapy was required in seven cases. Previously reported cases of pyoderma gangrenosum in children are reviewed, and the management of this skin disorder in childhood is discussed.

Adolescent↗
PubMed1983

Sinus tracts to the chin and jaw of dental origin.

This is a report of seven patients with cutaneous sinus tracts of dental origin who were seen in the past 10 years at the Mayo Clinic. Cutaneous sinus tracts of dental origin most commonly present on the chin or the mandibular region as nodulocystic lesions with suppuration. The lesion may be confused with pyogenic granuloma, foreign body reaction, deep fungal infection, squamous cell carcinoma, or osteomyelitis. However, if the lesion is suspected of being of dental origin, the diagnosis is easily confirmed by dental examination and dental roentgenograms of the involved area. Once the correct diagnosis has been made, treatment by appropriate endodontic therapy leads to prompt resolution of the sinus tract. This is an uncommon disease but one for which a high degree of alertness must be maintained when one sees a nodulocystic or ulcerative lesion of the face.

Adolescent↗