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Biomedical subjects

H O Perry

Publications and source records attributed to H O Perry.

At least 55 records · Page 3Linked to original sources
PubMed1983

Recent upper respiratory tract infection and pityriasis rosea: a case-control study of 249 matched pairs.

A sample of 249 patients was drawn from an original population of 939 patients with pityriasis rosea identified in an earlier population-based study of pityriasis rosea in Rochester, Minnesota. A control was selected for each case, matched for age, sex, and year of diagnosis. Comparison was made with regard to recent immunization, history of atopy, and recent infection. A statistically significant number of patients had experienced recent upper respiratory tract infection (P less than 0.005). The association between recent infection and pityriasis rosea is discussed.

Adult↗
PubMed1983

Direct immunofluorescence in pyoderma gangrenosum.

Direct immunofluorescence was done in fifty-one cases of pyoderma gangrenosum. Biopsy specimens were taken from the peripheral erythematous zone of the lesion. In thirty-one cases (61%), there was positive immunofluorescence, with perivascular deposition of immune reactants being the most frequent pattern (twenty-seven cases). These findings support a vasculitic pathogenesis of pyoderma gangrenosum.

Fluorescent Antibody Technique↗
PubMed1983

Subcorneal pustular dermatosis and pustular psoriasis. A clinicopathologic correlation.

The relationship between subcorneal pustular dermatosis (SCPD) and pustular psoriasis is discussed on the basis of a study of 23 patients with SCPD seen at the Mayo Clinic, Rochester, Minn, since 1956. In seven of the 23 patients, pustular psoriasis subsequently developed, and in three other patients there was associated psoriasis vulgaris. It was impossible to make a histopathologic distinction between SCPD and some cases of pustular psoriasis. The response to therapy with sulfones was erratic, if not ineffective. Our data suggest that disease identical to SCPD is, in many instances, strongly associated biologically, clinically, and histopathologically with psoriasis, and that continued observation of the clinical course may further substantiate this relationship in many cases.

Adult↗
PubMed1983

Pyoderma gangrenosum and monoclonal gammopathy.

The records of eight patients with pyoderma gangrenosum and monoclonal gammopathy showed that all patients except one had an IgA paraproteinemia. To date, seven patients have had a benign course and multiple myeloma has developed in one. In seven patients, the onset of the pyoderma gangrenosum preceded the detection of the monoclonal gammopathy. The monoclonal gammopathy did not seem to influence the morphologic findings, course, or therapy of the pyoderma gangrenosum. In the one patient with myeloma, treatment of the myeloma caused accelerated healing of the skin lesions.

Adult↗
PubMed1983

Incidence and trend of herpes progenitalis. A 15-year population study.

A population-based epidemiologic study of herpes progenitalis was conducted in residents of Rochester, Minnesota, for the 15-year period 1965 through 1979. Three hundred ninety-two patients (129 males, 263 females) were identified. The average annual incidence rate of herpes progenitalis was 50 per 100,000 population. A continuous increase in incidence was demonstrated throughout the study period (P less than 0.0005, trend test). In 1979, the incidence peaked at 128 per 100,000 population. The median age at onset was 24 years, and more than 80% of the patients were 18 to 36 years of age. Females predominated by 1.5:1 (P less than 0.001) and were, on the average, 4 years younger than the male patients. Although 15 pregnancies in the series were affected by herpes progenitalis, no neonatal herpes was noted, nor was the number of unfavorable outcomes of pregnancy unusual. No invasive or in situ genital carcinoma developed in patients after 1,544 person-years of follow-up.

Adolescent↗
PubMed1982

Risk of cancer after herpes zoster: a population-based study.

Herpes zoster has been associated with immune suppression, as has an increased risk of cancer. To determine whether patients with herpes zoster are at increased risk for subsequent cancer, we followed 590 residents of Rochester, Minnesota, for 9389 person-years after the diagnosis of herpes zoster. Subsequent relative cancer risks, overall and by specific site, were determined for the entire cohort and selected subgroups. In addition, relative risks of cancer during various intervals after the diagnosis of herpes zoster were determined. The overall relative risk was 1.1 (95 per cent confidence interval, 0.9 to 1.3). Relative risks of specific cancer sites were not different from unity except for those for colon and bladder tumors in women, both of which were slightly elevated. Patients with disseminated, recurrent, or gangrenous zoster, with postherpetic neuralgia, and with ophthalmic zoster wee not at elevated risk for subsequent cancer. These findings do not support the investigation of patients for occult cancer at the time of diagnosis of herpes zoster or enhanced surveillance for cancer after such a diagnosis.

Adult↗
PubMed1982

Recurrent incapacitating mucosal ulcerations. A prodrome of the hypereosinophilic syndrome.

The hypereosinophilic syndrome is a multisystem disease characterized by infiltration of eosinophils in bone marrow, heart, and other organs. Cutaneous involvement occurs, but usually it appears late in the disease and is of less importance than the cardiac and other organ involvement. We describe two patients with the hypereosinophilic syndrome (HES) in whom the initial manifestations of the disease were recurrent, severe mucosal ulcers involving the mouth and genitalia. In both patients, the mucosal involvement antedated the cardiac manifestations of the disease, and in both, the disease was refractory to treatment.

Adult↗
PubMed1982

Treatment of cicatricial (benign mucous membrane) pemphigoid with dapsone.

Treatment of cicatricial pemphigoid is a problem because patients afflicted are elderly, the disease is chronic, systemic agents required for control are potentially toxic (particularly to older patients), and the disease is often in an advanced stage when the diagnosis is established and requires aggressive therapy for control. We selected dapsone as an alternative anti-inflammatory agent because it has provided control in a subset of patients with bullous pemphigoid, five of six who had oral lesions. Twenty-four patients with cicatricial pemphigoid were treated with dapsone. Twenty (83.3%) had partial or complete control with mild to no inflammatory activity. Control was obtained within 4 weeks in eleven of the twenty patients. The use of dapsone was discontinued in two patients because it failed to control their disease and in four patients (two with control) because of drug-related side effects. Cicatricial pemphigoid may be added to the list of dapsone-responsive dermatoses.

Adult↗
PubMed1982

Plaquelike cutaneous mucinosis: its relationship to reticular erythematous mucinosis.

Nine patients with plaquelike cutaneous mucinosis, including the three described originally in 1960, are presented. The clinical manifestations of asymptomatic persistent, erythematous, infiltrated papules, either isolated or coalescing into plaques, in the midline of the back or chest are suggestive of the diagnosis. The dermal histopathologic findings of perivascular and periappendageal round cell infiltrates and mucin (acid mucopolysaccharides) on special stains confirm the diagnosis. This syndrome is more common among women, may be aggravated by exposure to ultraviolet light, and may subside spontaneously after long periods. We believe the condition of these patients is identical to that described as reticular erythematous mucinosis syndrome.

Adult↗
PubMed1982

Pityriasis rosea in Rochester, Minnesota, 1969 to 1978.

A population-based epidemiologic study of pityriasis rosea was developed for Rochester, MN, for a recent 10-year period. Nine hundred thirty-nine patients with pityriasis rosea (340 male patients and 599 female patients) who resided within Rochester city limits at the time the diagnosis was made were included. The average annual incidence rate of this disease was 172.2 per 100,000 person-years (158.9 per 100,000, adjusted to the 1970 U.S. white population). Female patients predominated by a margin of 1.5:1.0. More than 75% of the patients were between the ages of 10 and 35 years, with a mean age of 22.7 years and a range of 10 months to 78 years. There was a recurrence of the illness in 1.8% of the patients after an average of 4.5 years of follow-up. The highest rate was noted in 1972, following which there was a steady and significant decline in incidence. The incidence of the disease was significantly higher in the colder months than in the warmer season. Patients in twenty-one close-contact pairs experienced the disease at varying intervals. Recent past infections or history of atopy was noted in nearly one third of the cases.

Adolescent↗
PubMed1982

Population-based study of herpes zoster and its sequelae.

The epidemiology of herpes zoster and its sequelae have been investigated in a community-based study. The incidence rates observed in Rochester, Minnesota, are lower than those determined in practice-based series; and this may reflect some selectivity in practice-based series compared to population-based studies. No significant sex difference or seasonal variation was observed but the incidence did increase markedly with age. An increase in incidence was also observed over the 15-year period studied. The dermatomal distribution of herpes zoster observed in Rochester was quite similar to previous studies, despite their inherent biases in case ascertainment, except for a lower proportion with cranial nerve zoster. Herpes ophthalmicus (V1) appears to affect a slightly different population than zoster of the other dermatomes, with elderly males being more at risk. Also, herpes ophthalmicus is associated with a higher complication rate compared to the other dermatomes primarily due to the fragility of the involved organ. The elderly are also at greatest risk for the most common complication, post-herpetic neuralgia. The rate of PHN is not significantly increased in any particular dermatome but is significantly decreased in lumbar herpes zoster.

Adolescent↗
PubMed1982

Herpes gestationis.

Herpes gestationis is a rare, pruritic, blistering disease of the skin that occurs in pregnancy and the puerperium. Its recognition by those caring for the pregnant patient is important in determining appropriate care for the patient and in alerting the physician to possible effects on fetal outcome. Understanding of this disease has been rapidly expanding, and these advances are reviewed here through the use of an illustrative case report and a review of the literature. The evidence for significant risk of fetal morbidity and mortality, the potential indicators in patients who are at high risk, and the treatment approaches are stressed.

Adolescent↗
PubMed1981

Osteosarcoma arising in heterotopic ossification of dermatomyositis: case report and review of the literature.

A patient with dermatomyositis developed malignant transformation of the benign interfascial heterotopic bone. This patient had classic childhood dermatomyositis at the age of 3 years, and the disease was arrested after a one-year course of corticosteroid therapy. Extensive subcutaneous calcinosis cutis and deep interfascial calcinosis were the residua of the disease. Twenty-eight years later, the patient developed a high-grade osteosarcoma within the benign intermuscular heterotopic calcification and ossification that had been previously documented at the age of 8 years by a roentgenogram and at the age of 16 years by biopsy. This case represents the first report of the association of osteosarcoma and dermatomyositis, and possibly the first well-documented case of malignant transformation of benign heterotopic bone.

Adult↗
PubMed1981

Bowenoid papules of the penis.

The histologic finding of intraepithelial carcinoma of the penis presenting clinically as benign-appearing papules has been emphasized recently in the dermatology literature as bowenoid papulosis. We describe a patient who had multiple papules of the penile shaft, a biopsy specimen of which showed the typical histologic pattern of squamous cell carcinoma in situ. A review of the clinical morphologic range of intraepithelial carcinoma of the penis and the clinical resemblance to such conditions as lichen planus and condyloma acuminatum underscores the need to consider the possibility of squamous cell carcinoma in situ being expressed as bowenoid papules.

Bowen's Disease↗