Corneal decompensation in Chandler's syndrome. Clinical, histopathologic and ultrastructural study.
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Biomedical subjects
Publications and source records attributed to H Offret.
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Mycotic endophthalmitis has a poor prognosis particularly when it occurs in drug addicts. Ten ocular manifestations have been studied. These endophthalmitis all appeared after intravenous heroin injections. In one case, Candida albicans was found in the vitrectomy liquid. In two others cases, the mycosis was suspected after electrosynerese. Treatment gave different results because of the slight penetration of the different drugs into the eye. A therapeutic trial was conducted : 4 patients underwent vitrectomy raising the problem of surgical treatment of these affections.
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Study of 25 cases of obstruction of the central retinal vein. In the 4 first days it is a low level of arachidonic acid of platelet membrane. This fall of level is the one anomaly of fatty acid from platelet and plasma. We have obtained no correlation between the level of platelet AA and age or lipids level of the blood. Study of platelet agregation was performed in only some cases and no conclusion is possible.
An unusual vacuolated tumor of the iris pigment epithelium was investigated. Ultrastructural study showed a great variety of pigment granules in all the cells. The cells were of both the light and the dark epithelial type, with basement membranes and junctional complexes. The vacuoles were both intracellular and extracellular.
Literature review and report of personal cases concerning the ocular physiopathological problems of pregnant women. Are studied especially chorioretinal perturbations: surgical and medical retinal detachment, diabetic retinopathy, choroiditis with pseudohistoplasmosis and toxoplasmosis. Are also studied the variations of the visual acuity, ocular tumors and pituitary tumors.
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Description of three cases of buried drusen of the disk with pseudo-papilloedema and hemorrhages. These hemorrhages are splinter hemorrhages in the substance of the disk or deep peripapillary hemorrhage lying beneath the retina. OEdema and hemorrhage can produce transient blurring of the vision. They resolve in some weeks.
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Five cases of macular pigmentation with peripheral choroidal melanoma are studies. The pigmentation is in relation with accumulation of macrophages under the macula. These macrophages derive from the retinal pigment epithelium over the peripheral malignant melanoma of the choroid.
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The authors report a case of ocular manifestation of a Sipple disease. They discuss, the association with endocrine poly-adenomatosis and the relationship with the APUD system.
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Study of two patients with spontaneous detachment of the choroid. In addition to detachment of the choroid, case 1 had a flat anterior chamber. Corticotherapy gave some improvement but after 3 months, surgical management was necessary. In case 2 enucleation was performed on the basis of positive echographic findings. Histological findings, the main clinical features and the therapeutical approach are discussed.