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Biomedical subjects

H P Lambert

Publications and source records attributed to H P Lambert.

At least 37 records · Page 2Linked to original sources

Impact of whooping cough on patients and their families.

The effects of whooping cough were studied in 21 children admitted to hospital with the disease and in their families. The illness caused considerable distress to both child and family. Parents suffered especially from fears for the life and health of their child and from serious loss of sleep. Two months after admission the child's behaviour was still disturbed, but in most cases the rest of the family had returned to normal. There was much misunderstanding and misinformation about whooping cough among both parents and doctors.

Acute Disease↗

The severity of whooping cough in hospitalised children--is it declining?

Four hundred and sixty admissions for whooping cough to three hospitals between 1974-9 were reviewed. Many children had a long illness. More than half of them had severe or moderately severe coughing spasms and a quarter had pronounced feeding difficulties. The incidence of clinical pneumonia and convulsions was low and there were no deaths. The disease continues to be much more severe in infancy. There was some evidence that the disease declined in severity over the period studied. A number of factors including increased use of erythromycin may have contributed to this change.

Age Factors↗

Reading attainment and physical development after whooping cough.

Anthropometric measurements were made on 360 primary school children with a history of whooping cough and on 711 controls. Altogether 245 (68%) cases and 469 (66%) controls had taken tests of reading attainment and a smaller number had taken tests of intelligence. No significant differences were found between cases and controls in any of the anthropometric measurements nor in reading age or intelligence quotient after controlling for social class and parental smoking. Whooping cough is, in general, unlikely to cause subsequent deficiency in physical or mental development.

Adolescent↗

Respiratory morbidity and lung function after whooping-cough.

360 primary-school children with a history of whooping-cough were shown to have experienced an excess of other chest illnesses compared with 711 controls. This susceptibility may, however, have antedated the whooping-cough. Current respiratory symptoms were also more common in children who had had whooping-cough, though no differences were found on physical examination. No differences were found in lung function between cases and controls. Whooping-cough, as experienced by British children in recent years, is unlikely to cause subsequent respiratory morbidity and does not result in impaired lung function in later childhood.

Adolescent↗

Effects of erythromycin and gentamicin in experimental peritonitis.

Erythromycin and gentamicin were used to analyse the concept of bacterial synergy in an experimental model of acute appendicitis. Erythromycin given orally suppressed the aerobic flora other than the Enterobacteriaceae. When given by injection, a notable reduction in the counts of bacteroides and other anaerobic Gram-negative bacteria was also achieved. The addition of gentamicin, itself inactive against bacteroides, resulted in their total suppression. The implications of these findings are discussed.

Administration, Oral↗

Aspiration in seriously ill patients: a study of amylase in bronchial secretions.

Bronchial secretions from 21 patients with moderate to severe chest infections were obtained by transtracheal aspiration. Six seriously ill patients showed greatly increased levels of amylase activity in the bronchial secretions compared with those found in the 15 less ill patients. This amylase was almost certainly derived from oropharyngeal contents and its presence suggests that aspiration may be more common in comatose and semi-comatose patients than is generally appreciated.

Amylases↗