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Biomedical subjects

H P Lambert

Publications and source records attributed to H P Lambert.

At least 55 records · Page 3Linked to original sources
PubMed1979

Gastroenteritis in London and Jamaica: a clinical and bacteriological study.

The flora of both faeces and small bowel lumen was studied in children with gastroenteritis from London, England, and Kingston, Jamaica. Clinical and laboratory differences between these two groups are described. All bacterial groups in the faeces were greatly altered during gastroenteritis and this particularly affected anaerobic organisms. These changes generally reverted rapidly to normal after the illness. The small bowel flora was also altered during gastroenteritis; there was a tendency for a wider range of organisms including anaerobes to be isolated from the children in Jamacia than from those in England.

Acute Disease↗
PubMed1979

Escherichia coli in gastroenteritis of children in London and Jamaica.

The jejunal and stool flora of children with gastroenteritis in London and in Jamaica was examined. Although bacterial colonization of the small bowel was commonly detected, it was unusual to find the same serotype of E. coli in both jejunum and stool, and none of the jejunal strains of E. coli produced either heatlabile or heat-stable enterotoxin. Some strains of E. coli causing infant gastroenteritis are neither toxigenic nor invasive, and other mechanisms must be sought to account for their pathogenicity.

Acute Disease↗
PubMed1978

Clinical significance of tissue penetration of antibiotics in the respiratory tract.

Concentrations of antibiotics in bronchial secretion vary widely and cannot be easily related to physico-chemical characteristics. Serum and sputum concentrations do broadly correlate in the case of penicillins, some cephalosporins and some tetracyclines. Antibiotic concentrations in bronchial secretion (although not necessarily in lung tissue) are always much lower than in serum, with a ratio of about 20% for tetracycline, 3--4% for ampicillin, 4--50% for gentamicin and tobramycin. Concentrations will often be adequate to inhibit highly sensitive pathogens but marginal or ineffective for those less sensitive, e.g. carbenicillin or gentamicin for Ps. aeruginosa.

Aminoglycosides↗
PubMed1977

Hydroxyproline excretion in infantile gastroenteritis.

Total hydroxyproline/creatinine ratio (THP:Cr) was measured in random urine specimens from 18 infants with gastroenteritis. THP:Cr was sometimes increased during the acute phase of the illness and the reasons for this are discussed. Seven patients failed to thrive after the acute phase and THP:Cr was low in all of these. The test appears to be a sensitive indicator of the onset of failure to thrive, and it is suggested that it may be of value in the management of these patients.

Child↗
PubMed1977

Erythromycin and anaerobic infection.

The theoretical basis of the use of erythromycin in peri-operative prophylaxis after bowel surgery will be discussed and the results of the use of erythromycin in such patients and the sensitivity to the antibiotic of isolates from human peritonitis described. This work will be related to results obtained in a rabbit experimental model for the study of peritonitis.

Acute Disease↗
PubMed1975

The faecal flora of children in the United Kingdom.

The faecal flora of 55 children (aged 8 days to 8 years) and 16 adults was determined. All the children were artificially fed from birth. The faecal flora of the youngest age group was generally less complex and less predictable than that of adults. Some bacterial groups commonly found in adult stools, for example bacilli, lactobacilli and yeasts, were rarely found in the youngest infants. Most of the changes towards the adult pattern took place between 4 and 12 months. The faecal flora of children aged 1-4 years generally resembled that of adults, although lactobacilli were still infrequently isolated.

Adolescent↗
PubMed1975

Assessment of simple methods of measuring intestinal transit times in children with gastroenteritis.

Intestinal transit times in children less than 3 years old with gastroenteritis were measured using carmine suspension and radioopaque pellets. Carmine transit times were short as expected in the acute illness, and lengthened on recovery to the values found in children without diarrhoea. Pellet transit times of the sick children were the same as those of controls without bowel disease. Solid markers may thus be misleading in acute diarrhoeal illness of childhood. Possible mechanisms are discussed.

Child, Preschool↗