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Biomedical subjects

H Pflüger

Publications and source records attributed to H Pflüger.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Tissue plasminogen activator activity in early prostatic cancer and in bone metastases of prostatic cancer].

Most malignant cells exhibit increased plasminogen activator activity which, in turn, leads to the formation of the fibrinolytically active enzyme, plasmin. Since solid tumours in man are surrounded by a fibrin network, the fibrinolytic activity of the tumour may influence tumour growth and metastasis. In the present study plasminogen activator activity, as assessed in purified extracts, was compared in benign hyperplasia of the prostate (group A, n = 6), non-metastasizing+ prostatic carcinoma (group B, n = 26), and in prostatic carcinoma with bone metastasis (group C, n = 10). Plasminogen activator activity was significantly higher in prostatic carcinoma than in hyperplasia, but there was no significant difference in plasminogen activator activity between prostate carcinoma with or without bone metastasis. However, plasminogen activator activity in the bone metastasis cells was significantly higher than in the primary tumour. If a positive correlation between fibrinolytic activity of the tumour and the metastasizing capacity were postulated, particular importance could be attached to bone metastasis in prostatic cancer.

Bone Neoplasms↗
PubMed1984

Tissue plasminogen activator activity in prostatic cancer.

19 patients with carcinoma of the prostate and 6 controls with hyperplasia of the prostate, have been investigated to elucidate the relationship between tumor fibrinolytic activity, the degree of malignancy, tumor stage and metastatic spread. Significantly (p less than 0.001) higher tissue plasminogen activator activities were found in metastatic carcinoma compared to nonmetastatic carcinoma or hyperplasia of the prostate. Antibodies against human urokinase caused inhibition of urokinase and plasminogen activator activity from human prostatic carcinoma or hyperplasia. Antibody inhibition studies as well as physicochemical characteristics of the plasminogen activator produced by prostatic hyperplasia and carcinoma tissue indicate that this plasminogen activator is identical or similar to urokinase.

Antibodies, Neoplasm↗
PubMed1983

Turner syndrome: spontaneous growth in 150 cases and review of the literature.

The spontaneous growth of 150 patients with Turner syndrome from three German centers--90 with 45,X0 constitution, 60 with other chromosomal abnormalities--has been analyzed. The mean adult height was found to be (n = 14) 146.8 cm. It was observed that growth in these patients can be divided into four phases: (1) Intrauterine growth, which is retarded; (2) Height development, which is normal up to a bone-age of about 2 years; (3) Between a bone-age of 2 and 11 years when stunting of growth is most marked; (4) After a bone-age of 11 years--the time at which puberty should normally start--the growth phase is prolonged, but total height gain is only little below normal levels. No difference in height could be observed between cases with X0 karyotype and other chromosomal variants. The data are compared with those in the literature.

Adolescent↗
PubMed1983

Effects of antiproteases (aprotinin and gabexate-mesilate) on the postischemic vascular response of the kidney.

Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic changes produced by 60 min of normothermic ischemia, i.e., postischemic hyperemia and reduction of vascular resistance, were equally mediated by kallikrein. Vascular responses were evaluated by determining renal cortical blood flow using radioactively labelled microspheres, by calculating vascular resistances, and by measuring the diameters of renal medullary vessles. Kidneys exposed to normothermic ischemia and sham-operated control organs of animals treated with aprotinin (2 X 40,000 KIU/kg body weight) and gabexate-mesilate (2 X 7 mg/kg body weight) were compared with those of rabbits which were analogously operated, but did not receive any drugs. As the antiproteases used did not significantly affect the hyperemia and the reduction of renal cortical vascular resistance seen after 60 min of normothermic ischemia, these phenomena are apparently not mediated by kallikrein. Renal medullary vasodilatation (arteriolae rectae) was significantly lower under aprotinin than in untreated ischemic kidneys, and was not longer demonstrable in gabexate-mesilate-treated animals. Thus, the effect of gabexate-mesilate was superior to that of aprotinin. Whether the antiprotease action is due to an unspecific membrane-stabilizing, to a general enzyme-inhibiting, or to a specific kallikrein-inhibiting effect, is still unclear.

Animals↗
PubMed1983

Effects of external renal hypothermia on postischemic hemodynamics.

In the rabbit model renal cortical blood flow after 60 min of normothermic ischemia is seen to rise significantly in the early reperfusion period. Under otherwise identical conditions this phenomenon is absent after hypothermic ischemia produced by surface cooling of the kidney and in sham-operated kidneys. It is still unclear whether postischemic hyperemia is a physiologic counterregulatory mechanism in response to 60-min normothermic ischemia of the rabbit kidney or a contributory factor in the development of acute postischemic renal failure.

Acute Kidney Injury↗
PubMed1983

Renal blood flow alterations after temporary ischemia. An experimental model in the rabbit.

In an effort to investigate the efficiency of various pharmacological agents in protecting the kidney against normothermic ischemia, an animal model was developed and the post-ischemic hemodynamics in the renal cortex of rabbit kidneys were studied. Renal cortical blood flow was evaluated 5-30 min after 60 min of normothermic ischemia of the left kidney using 141Ce-, 51Cr-, and 85Sr-labelled microspheres. Control groups were subjected to sham operation. The right kidneys served as individual controls. Ischemic kidneys showed a significant weight increase independent of reperfusion. Furthermore, a transient highly significant increase of cortical blood flow was found with an absolute maximum about 10 min after termination of ischemia. This increase in cortical blood flow was paralleled by a highly significant decrease of vascular resistance.

Animals↗
PubMed1983

[Prostaglandin E2--an improvement in the therapy of bladder emptying disorders?].

21 patients suffering from bladder motor disturbances were investigated by simultaneous pressure-flow studies before and after intravesical application of PGE2. The detrusor response as well as the influence on the bladder outlet resistance were registered. A remarkable improvement of the detrusor function could only be obtained in cases with intact sacral reflex-arcs with isolated transitory myogenic disturbances. Neuromyogenic bladder disturbances could not be influenced permanently by PGE2 instillations.

Adolescent↗
PubMed1983

[ Fournier gangrene: a rare complication of multiple myeloma].

A 69-year-old male patient with multiple myeloma developed a dolent swelling of the right side of his scrotum at the time of maximal leukocyte depression after cytostatic drug therapy. Within a few hours the scrotal skin became gangrenous. After surgical debridement of the necrotic tissues and simultaneous antibiotic therapy the necrosis showed a favorable course.

Aged↗
PubMed1982

Idiopathic uric acid lithiasis: epidemiologic and metabolic aspects.

Of 264 patients with urolithiasis those with pure uric acid or urate stones were compared to those with other types of calculi for differences in epidemiologic factors and uric acid, calcium and phosphate metabolism. Patients with uric acid stones were predominantly older men. These patients had comparatively lower incomes and spent less money on food but consumed more alcohol. The urinary pH was lower than in the other groups. The absence of abnormally elevated serum uric acid levels and elevated 24-hour urinary uric acid excretion suggests this variety of uric acid lithiasis to be idiopathic in nature. This finding is supported by the results of standardized oral purine loading, which showed no post-loading differences in serum levels and revealed urinary concentrations in 12 patients with pure uric acid stones and 10 normal subjects. However, there is evidence to suggest that this condition may be a precursor of primary gout. Hereditary mechanisms are absent and the relapse rate is the same as in patients with other stones. Therefore, our results suggest the existence of an idiopathic variety of uric acid lithiasis that, at least in central Europe, occurs more frequently than previously assumed. The condition is not inherited, alcohol consumption is a major etiologic factor and there is no evidence of a causative role of abnormalities in purine metabolism.

Age Factors↗
PubMed1982

[In vivo and in vitro degradation of fibrin adhesives (studies in rats)].

The fibrin seal (FS) is of indisputed value for hemostasis and atraumatic tissue synthesis in surgical therapy. In order to determine the optimal FS composition for resistance against fibrinolysis, in vivo lysis was tested by adding increasing amounts of the fibrinolysis-inhibitor aprotinine to 125I FS; urokinasis and plasminogen were administered in vitro while measuring protein and 125Iodine release. The correlation of protein and 125Iodine release clearly reflects the interdependence of both parameters; disjunction of radioactivity from the protein molecule was ruled out. In vitro, fibrinolysis is inhibited to a nearly unlimited extent by aprotinine. In vitro, aprotinine improves fibrinolysis inhibition only up to a maximum of 1500 KIE/ml clot, thereby significantly altering the maximum elimination of 125Iodine and FS half-life as well. Higher doses of aprotinine applied in vivo remain without effect upon FS stability. In human surgery, the addition of aprotinine to FS is recommended for strictly hemostyptic application only, but not for tissue synthesis such as nerve- and microvessel-anastomoses in plastic reconstructive surgery.

Animals↗
PubMed1982

[Can silicon diffusion from silicone rubber catheters cause urethral stricture?].

Silicon-leakage out of alloplastic Silicon containing implants induces myofibroblast proliferation and constricting scar tissue. Therefore the possible Silicon-leakage out of Silicon rubber Foley-Catheters was of major interest. This cathaters were often used after internal urethrotomies of recurrent urethral strictures. Pieces of Silicon rubber Foley-Catheters of 18 F, 2 cm in length, were implanted subcutaneously and intraperitoneally in rats. Using Scanning electron microscopy and EDXA (energy dispersiv x-ray microanalysis) Silicon could not be identified in tissues around the implants 6 and 12 weeks after implantation. Therefore Silicon-leakage out of Silicon rubber Foley-Catheters is not responsible for recurrent urethral strictures.

Animals↗
PubMed1981

[The social infrastructure of patients with urinary calculi (author's transl)].

The social infrastructure was investigated in 379 patients with urinary stones. The rates of 50% for employees and 32% for old-age pensioners were surprisingly high. 16% of the patients were employed in jobs with hard manual labour. Only 9% of the patients went in for regular physical activity in their leisure. A significant increase in urinary excretion of calcium and uric acid (p - 0.01) and inorganic phosphate (p less than 0.001) was seen in connexion with increase in net income. On the other hand, urinary pH was lowest in the highest income group (p = 0.01). According to these findings an increased net income combined with a lack of physical exercise seems to enhance the risk of stone formation.

Adolescent↗
PubMed1981

Partial rat kidney resection using autologous fibrinogen thrombin adhesive system.

The Fibrinogen Thrombin Adhesive System (FTAS) enables local haemostasis to occur in parenchymatous organs without tissue damage. The aim of this study was to investigate the degradation of FTAS and the process of wound healing after partial kidney resection in rats using FTAS for induction of local haemostasis. In 28 rats partial kidney resection was performed bilaterally. Haemostasis was achieved with Fibrinogen Thrombin Adhesive System. Four experimental groups were formed. Group A (n = 3): Haemostasis with unlabelled FTAS, subcutaneous injection of 0.1 ml = 60 mu Ci Na 125I. Group B (n = 3): Haemostasis with unlabelled FTAS, subcutaneous injection of 0.1 ml = 60 mu Ci 125I FTAS. Group C (n = 6): Haemostasis with 125I labelled FTAS. Group D (n = 16): treated like Group C. In Groups A - C 125I-elimination in 24 h urine samples was determined with a gamma-scintillation counter. Pairs of animals in Group D were killed after 2, 6, 12 and 24 h and 3, 7, 14 and 21 days. Kidneys were examined under the light and electron microscope and by autoradiography. In animals of Groups B and C two peaks of 125I excretion were observed: one peak within the first 48 h postoperatively which corresponded to the amount of free iodine injected with FTAS (FTAS contains 15% free iodine); a second peak after 120 h which was most probably due to the degradation of FTAS. Fibrinolysis was not observed. FTAS was resorbed mainly by macrophages. The time course of wound healing paralleled that of physiological fibrinogen concentration. Renal parenchymal damage was not observed.

Animals↗
PubMed1981

Nutritional risk factors in urinary stone disease.

The relationships between eating and drinking habits, and serum as well as 24-hour urinary concentrations of calcium, inorganic phosphate uric acid and urinary pH were studied in 379 patient in whom stones form. The 24-hour urinary calcium excretion was found to be increased in patients who preferably eat animal proteins and farinaceous foods (p less than 0.1). Regarding drinking habits, urinary calcium and inorganic phosphate excretion was found to increase significantly as a function of alcohol ingestion (p less than 0.01 and p less than 0.001, respectively). Similarly, an increased alcohol intake was found to be associated with higher serum uric acid concentrations (p less than 0.01). A significant increase in urinary pH was confined to patients preferably eating vegetables (p less than 0.005). The results of our study suggest alcohol consumption to be a potentiating factor for the risk of stone formation.

Adolescent↗
PubMed1981

[Oral purine loading in the routine diagnosis of patients with urinary calculi].

Oral purine loading: a diagnostic procedure in stone forming patients. 95 stone formers (83 patients with calcium oxalate and calcium phosphate, 12 patients with uric acid stones) and 10 healthy volunteers were given 2 g guanosine as an oral purine load. Calcium oxalate and caldium phosphate stone formers showed two different patterns of uric acid excretion after oral purine loading, correlating with different incidence of recurrent stone formation. Patients with uric acid lithiasis showed initially lower values of urate excretion, after oral purine load no difference of uric acid excretion compared to normal controls was seen.

Female↗
PubMed1980

[Raised cerebrospinal fluid pressure by intravenous administration of anesthetics].

Anaesthesia in disaster situations and in traumatology will be done with ketamine, propanidid and in some cases with a single shot methohexital. The intravenous injection of ketamine as well as propanidid is followed by a significant increasing of the cerebrospinal fluid pressure. Only barbiturate derivates cause a depression of cerebrospinal fluid pressure. The results are demonstrated in experiments with dogs.

Anesthetics↗
PubMed1980

Oral purine loading for evaluation of uric acid excretion in patients with urinary calculi.

We present a model for oral uric acid loading which may be used to study the relapsing tendency of stone-formers. The oral administration of 2 g of guanosine was associated with two different response patterns of urinary uric acid excretion in patients with urolithiasis. The two groups also had considerably different relapse rates. The relapsing tendency in the group with the comparatively decreased reaction of urate excretion was less pronounced than in the group with enhanced uric acid excretion after oral purine loading.

Administration, Oral↗