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Biomedical subjects

H Poppius

Publications and source records attributed to H Poppius.

At least 37 records · Page 2Linked to original sources
PubMed1980

Slowly progressive bronchiolitis obliterans. A case report with detailed pulmonary function studies.

A case of idiopathic bronchiolitis obliterans in a 40-year-old man is presented. The chest radiograph showed miliary nodules, which on histological examination were found to consist of granulation tissue in and around bronchioles causing narrowing or obliteration of the airway lumen. The pulmonary function tests indicated a milk degree of airway obstruction, ventilation/perfusion inequality, hypoxemia which increased during exercise, and a well-preserved diffusion capacity suggesting absence of significant damage to the interstitium of the lung. Radiospirometry suggested that the functional derangement was most prominent in the lower parts of the lungs. Even though the inflammatory component was prominent no improvement was observed during steroid therapy. A history of respiratory symptoms for 20 years and a slight deterioration of the respiratory function over a follow-up period of 4 years suggested an unusually slow rate of progression of the disease.

Adult↗
PubMed1980

[Treatment of chronic cicatricial laryngeal stenosis (author's transl)].

Eighty severe cases of chronic laryngeal stenosis in patients aged 1--78 years, where all other treatment had failed, were operated upon with laryngofissure of the front and back wall of the larynx followed by excision of the stenosis scar tissue. An endolaryngeal prosthesis was inserted and left in position for four months. The clinical result was good in 69 patients but, for various reasons, unsuccessful in eleven. The results of the treatment was also investigated by spirometry and body plethysmography. Contraindications for this operation are presented. The mean follow-up time was 6.9 years.

Adolescent↗
PubMed1979

Comparison of pirbuterol and pirbuterol and hydroxyzine in patients with reversible airway obstruction.

The effects of single oral doses of pirbuterol 10 mg plus hydroxyzine 10 mg, and of pirbuterol 10 mg plus placebo, were compared in a single-blind cross-over trial in 17 adult patients with reversible airway obstruction. The initial bronchodilator response after the two treatments was similar, but mean specific airway conductance at 3, 4, 6 and 8 h, and mean FEV1 and FVC after 3 and 4 hours, were significantly higher after pirbuterol + hydroxyzine than after pirbuterol + placebo. The mean thoracic gas volume measured at 3 and 4 h was lower after pirbuterol + hydroxyzine. Heart rate, blood pressure and a continuous ECG record did not differ after the two treatments. The findings suggest that the combination of pirbuterol and hydroxyzine brings about more prolonged bronchodilatation in patients with reversible airway obstruction than does pirbuterol alone.

Adult↗
PubMed1979

Preventive effect of ketotifen, a new antiallergic agent, on histamine-induced bronchoconstriction in asthmatics.

The preventive effect of ketotifen, a new drug with anti-histaminic and antiallergic properties, on histamine-induced bronchoconstriction was studied by open assessment in twenty-four adult patients with extrinsic asthma. A single oral dose of 1 mg ketotifen reduced the post-histamine mean drop in peak expiratory flow from 33 to 16% of the basal values (P less than 0.001). After a 4 weeks' regimen of 1 mg ketotifen twice daily the post-drug histamine-induced fall in PEF was further significantly reduced (P less than 0.001). Tests performed after 8 and 12 weeks of treatment showed no additional decrease in bronchial reactivity to histamine. Tests performed 1 week after cessation of treatment showed return of bronchial reactivity to the pretreatment level. The results suggest that a single dose of ketotifen has a marked preventive effect on histamine-induced bronchoconstriction and that this effect is enhanced during continued treatment.

Adolescent↗
PubMed1979

A controlled study on the preventive effect of ketotifen, an antiallergic agent, on methacholine-induced bronchoconstriction in asthmatics.

We studied the preventive effect of ketotifen, an oral drug with antianaphylactic and antihistaminic properties on methacholine-induced bronchoconstriction in controlled cross-over experiments in twenty-six adult patients with extrinsic asthma. Both a single dose of 1 mg ketotifen and 4 weeks treatment of ketotifen, 1 mg twice daily, failed to reduce the methacholine-induced drop in peak expiratory flow. The spirometric findings remained unchanged during ketotifen treatment. There was no difference between treatments with ketotifen and placebo with regard to the patients assessment of the severity of asthma or airway sensitivity to tobacco smoke, fumes or dusts, or exercise. The results suggest that treatment during 4 weeks with ketotifen does not reduce unspecific broncial hyperreactivity in patients with extrinsic asthma.

Adolescent↗
PubMed1979

Effect of ipratropium bromide and fenoterol on airway obstruction in chronic pulmonary tuberculosis.

Single-blind, cross-over comparison of standard doses of ipratropium bromide (2 puffs of 0.02 mg each) and fenoterol (2 puffs of 0.2 mg each) in 36 pairs of experiments in 6 patients with partially reversible airway obstruction, presumably secondary to chronic widespread pulmonary tuberculosis, revealed no difference between the drugs in bronchodilating effect, evaluated by peak-flow measurements and spirometry. The inhalation of isoprenaline at the end of the experiment induced no further improvement in the lung function variables measured. The results suggest that a vagal reflex mechanism plays a major role in bronchoconstriction connected with severe chronic pulmonary tuberculosis.

Adult↗
PubMed1979

Determination of specific airway conductance by a simplified plethysmographic procedure.

Attention is drawn to the fact, obvious for simple mathematical reasons, that in patients that airway obstruction the values for specific airway conductance (SGaw) calculated directly from the flow-pressure loop registered during quiet breathing with a constant-volume body plethysmography closely approximate the values obtained by the conventional plethysmographic method which includes temporary interruption of the airflow. The simplified procedure may be useful e.g. in serial determinations of SGaw in situations where simultaneous measurement of the lung volume is not considered essential.

Airway Obstruction↗
PubMed1978

Controlled study of the bronchoconstriction effect of pindolol administered intravenously or orally to patients with unstable asthma.

Pindolol, a beta-blocking drug, was given intravenously (0.2 mg) to 4 patients and orally (15 mg) to 4 patients, all in remission after acute exacerbation of asthma. In all cases it induced chest tightness and marked decrease in specific airway conductance, FEV1 and FVC and maximum expiratory flow at low lung volumes. The increase in airway obstruction after pindolol was not reversed by inhalation of a beta-sympathomimetic aerosol. The results suggest that conventional doses of pindolol may cause significant worsening of asthma in patients with unstable disease.

Administration, Oral↗
PubMed1977

Exercise-induced asthma and doxantrazole.

In a double-blind cross-over trial in 13 patients with exercise-induced asthma, doxantrazole 200 mg taken orally 1 hour before a standardized exercise test involving stair climbing failed to block post-exercise bronchoconstriction. In an open assessment study with the same patients, increasing the doxantrazole dose to 400 mg did not affect post-exercise bronchoconstriction.

Adolescent↗
PubMed1977

Acute bronchodilating effect of transcutaneous nerve stimulation in asthma. A peripheral reflex or psychogenic response.

The acute effect of electric transcutaneous nerve stimulation (TNS) on bronchomotor tone was studied in 20 asthmatics. The stimulation was applied to four classical acupuncture points on the chest and back, and bronchomotor response was determined by measuring peak expiratory flow (PEF). The experiments consisted of an adaptation period, placebo "stimulation", TNS, and an isoprenaline inhalation test, in that order. In 11 patients PEF increased significantly (greater than 15%) after placebo "stimulation"; the mean change in all 20 patients after that period was + 12% (P less than 0.01). TNS, however, did not change PEF significantly in any patient in spite of the fact that marked residual bronchoconstriction was shown in all patients demonstrated by an increase in PEF after inhalation of two isoprenaline puffs at the end of the experiment. The results suggest that the acute bronchodilatation obtainable with TNS is probably psychogenic; no cutaneous-bronchial reflex could be demonstrated. The same kind of psychogenic reaction may also be involved in the bronchodilator response to needle acupuncture in asthma.

Adult↗