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Biomedical subjects

H Pullmann

Publications and source records attributed to H Pullmann.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Retinoid PUVA (RePUVA): systemic combination therapy in psoriasis].

RePUVA is a new therapeutic approach in psoriasis, consisting in oral administration of a retinoid derivative and systemic PUVA treatment. The retinoid (Ro 10-9359) was given daily (50--75 mg) before, simultaneously and, before and simultaneously with PUVA. The overall response was 73%; however, 14 patients resistant to previous standard PUVA treatment also responded surprisingly well to RePUVA. If PUVA-resistent patients were excluded, the overall response was 82.6%. The mean number of treatments required for clearing was 19.4 +/- 6.1, the mean total UVA-dose 57.9 +/- 32.3 J/cm2 and the mean duration of treatment was 55.4 +/- 14.1 days, including pretreatment with retinoid. It seems that RePUVA may be most successful if the retinoid is given before and with PUVA: 33.7 +/- 8.7 J/cm2 in 17.0 +/- 4.7 sessions were then required for clearing. Compared with previous results of our group and recent publications these findings indicate that the RePUVA schedule may reduce the duration of treatment and the total UVA-dose and, therefore, the possible long-term hazards of PUVA management. In addition, RePUVA can be successfully applied in patients resistant to standard PUVA.

Coumarins↗
PubMed1978

[Vitamin A acid for the topical management of epithelial neoplasms. Combination with 5-fluorouracil].

15 patients with superficial basaliomas or premalignant epithelial neoplastic disorders (actinic keratosis, leukoplakia, Bowen's disease) were treated locally over three weeks with retinoic acid (RA) alone or in combination with 5-fluorouracil (5-FU). In 11 cases the lesions disappeared clinically, however, only 5 patients proved to be cured by histological examination. 4 of them were treated with RA combined with 5-FU. There was a decrease of the 3H-index after the first week and an increase after the third week of treatment. These findings suggest, that RA inhibits the proliferation of neoplastic keratinocytes and stimulates the proliferation of normal epidermal cells. Retinoic acid, therefore, has an inhibitory effect on epithelial neoplasias, particularly in combination with 5-FU. Since local therapy with RA and 5-FU is not sufficient for routine clinical purposes in all cases, their use should be restricted to selected patients.

Aged↗
PubMed1977

[Diagnostic value of RAST-classes in various allergens].

Specific IgE-fractions can be determined in the blood serum by Radio-Allergo-Sorbent-Test (RAST). The positive tests are arranged into four groups, the so called RAST-classes, of which class 1 represents the lowest, class 4 the highest content of specific IgE. The diagnostical value of equal RAST-classes among the groups of allergens is different. We examined 13 600 allergens in 700 patients by RAST and found 2441 positive reactions. It turned out that especially in weeds, house dust and mould allergy, the lower RAST-classes are predominant with more than 90 per cent. In grass pollen allergy, a comparable percentage of positive tests accumulates in the range of RAST-class 3. From this distribution of positive tests we concluded, that in house dust, mould and weeds pollen allergy RAST-class 1 has a real diagnostical value and can be the basis of therapeutical consequences. In patients with lower RAST-classes in mould, house dust and weed pollen allergy, in our experience, the average total IgE is already in a pathological range; in patients with grass pollen allergy total IgE is increased pathologically almost until RAST-class 4.

Allergens↗
PubMed1977

Disturbance of DNA-Synthesis in early psoriasis.

In earlier studies we have shown that there is a significant prolongation of DNA-synthesis time (ts) in the epidermal cells of fully developed psoriatic lesions. The present study shows that this prolongation is to be observed even in very early plaques. The prolongation of ts precedes the development of acanthosis. A dermal infiltrate with increased proliferative activity seems to be a stimulus, in the sense of a Koebner-phenomenon. There is no pronounced prolongation of ts in other acute or chronic inflammatory processes of the skin. The behaviour of the infiltrate in psoriasis is similar to that in allergic patch test reaction. However, the abnormal psoriatic epidermis, with disturbed DNA-synthesis, does not react to the above mentioned infiltrate with a limited hyperproliferation but with the development of a psoriatic plaque. There is obviously congenital disturbances of metabolism within the epidermal cells in psoriasis.

Acute Disease↗
PubMed1977

[Double-lobed rotation pedicle flap].

This is a report on the bilobed rotation pedicle flap, a special type of pedicled flap transfer. The method is suitable for reconstruction of roundish skin defects, dermis and subcutaneous tissue with diameters from 8--15 cm, especially in dermato-tumorsurgery in trunk and thigh regions. The regional flap consists of two tongue-shaped donor lobes separated by the wound. The conventional form of the bilobed flap has an angle of 180 degrees between the bases of the lobes. By shifting the tissue at the surrounding of the defect, the procedure has the distinct advantage of camouflaging the donor sites. In addition it reduces the size of the wound. With the final transposition of the relatively small lobes large defects can be closed without the use of additional skin grafts. The method, here described in ten cases, is a simple way to resurface and reconstruct the wound with good functional and cosmetic result.

Adult↗
PubMed1976

[PUVA and anthraline therapy of psoriasis, a clinical, histological and autoradiographic comparison].

Treatment of psoriasis with 8-Methoxypsoralen and long wave ultraviolet rays (UV-A) (PUVA) was carried out on 63 patients with severe psoriasis. 41 patients were given the medication orally, the other 22 had it applied locally. After 8.5 weeks, with an average of 25 radiations, about 54% of the patients were cleared of all symptoms or improved considerably. Histological and autoradiographical examinations were carried out to 10 of the orally treated patients. After three weeks of treatment we found a reduced H 3-thymidine-labelling-index (H 3-I) and a shortened DNA-synthesis-time (ts). The average cell cycle time (tc) was lengthened. The effect of PUVA is comparable to that of Anthralin therapy, but the clinical success and the length of treatment with the PUVA-method are inferior to those of the Anthralin-method. There we consider the Anthralin-method as used on in-patients at the Department of Dermatology at the University of Cologne, to be the more suitable method. The PUVA-method ist less complicated and its application easier for the physician as well for the patient, therefore we consider the PUVA-method more suitable for the treatment of out-patients.

Adult↗
PubMed1976

Dopa-positive cells and melanin in basal cell epithelioma (BCE).

In 47 out of 61 bce's, melanocytes were detectable with the aid of Dopa-reaction. In 24 of these cases, the percentage of tumour cells was less 5%, and in 23 it was more. The melanocytes preferred the periphery of the epithelial tumour formations. Only when the proportion of melanocytes exceeded 5% were they also to be found in the central parts of the tumours. Generally the melanocytes were more numerous in the upper parts of tumours, next to the epidermis. Our findings strengthen the opinion, that bce is a tumour of the primary hair germ.

Basal Cell Carcinoma↗
PubMed1976

[Cytokinetics of epidermal and dermal cells in allergic contact dermatitis and atopic dermatitis (author's transl)].

The cytokinetics of epidermal and dermal cells was examined in 16 patients with subacute or chronic allergic contact dermatitis and 11 with atopic dermatitis. In allergic contact dermatitis a H3-thymidine-labelling index (H3-1) of 4.55 +/- 2.4% was found in the epidermis and of 0.7 +/- 0.44% in the dermal infiltrate. In comparsion, in atopic dermatitis the values were 5.5 +/- 2.31% in the epidermis and 0.93 +/- 0.72% in the dermis. The DNA-synthesis-time (ts) was lengthened slightly with 11.4 +/- 2.4 h in allergic contact dermatitis and 11.75 +/- 3.68 h in atopic dermatitis. In comparsion with normal skin, the cell-cycle-time (tc) was slightly shortened in allergic contact dermatitis (244 +/- 110 h) and in atopic dermatitis (233 +/- 83 h). There was no significant difference between both types of dermatitis regarding cytokinetics.

Cell Division↗