[Misinterpreted hyperbilirubinaemia].
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Adult↗
Biomedical subjects
H Pusch
Publications and source records attributed to H Pusch.
[Clinical, endocrinological, histological and chromosomal investigations on Klinefelter's syndrome].
In a clinical study 101 patients with Klinefelter's syndrome (Kl. sy.) are evaluated. Clinical, endocrinological and histometrical aspects were of main interest. The results were compared with a group of patients with azoospermia by obstruction. The statistical evaluation showed significant differences concerning body-height, volume of ejaculate, size of testis, and the concentration of FSH and LH in serum. Histometrical investigations showed significant differences for the diameter of seminiferous tubules and their wall-thickness. The various degrees of Leydig-cell-increase at Kl. Sy. are described as--increased--excessively increased--and adenomalike. Sex-Chromatin was found positive in 62 of 64 cases of Klinefelter's syndrome, verified by chromosome analysis. The number of Barr-bodies ranged from 1-45 (200 cells evaluated) x mean was 9,6. The analysis of chromosomes in 64 cases showed a karyotype of 47,XXY in 59 cases, a 46, XY/47,XXY mosaic in 4 cases and 46,XX/46,XY/47,XXY mosaic in 1 case. The discussion pointed out, that Kl. sy. has no typical, but a variety of symptoms. The position of the evaluation of sex-chromatin for diagnosis and the possibilities of errors are discussed. The problem of fertility in Kl. sy. is mentioned, as we found two cases with complete spermatogenesis, yet with azoospermia, among our patients. The pathogenesis of the characteristical histological changes in testis with Kl. sy. remains open. The mechanism which may lead to the striking increase of Leydig-cells is discussed.
Adolescent↗
[Evaluation of semen by electronic spermcounter].
The new electronic spermcounter was developed to make andrological routine work easier. The apparatus is a complete microcomputer and has three main functions: The counter function allows to determine the number of spermatozoa and round cells at the same time. The morphological function allows the detailed morphological analysis of stained spermatozoa specimen within a reasonable time. Besides the determination of normal and pathlogical forms a more exact differentiation of the respective pathological spermatozoon is possible. The timer function guarantees the exact timing of the evaluation of sperm motility. We judge the motility immediately after ejaculation and 30, 60, 120, 240 minutes later. Using the electronic sperm counter in the andrological routine laboratory and for detailed morphological studies we observed an improvement of the quality of our results and a remarkable saving of time. It is evident, that the spermcounter is a valuable equipment for all institutions performing investigations on sperm, of instance clinical and practical andrologists, veterinarians and scientists working in the field of reproduction.
Humans↗
[XX-male syndrome from the andrologic viewpoint].
Three cases of XX-male Syndrome which have been evaluated at the Department for Andrology of the University-Hospital Hamburg are reported. The clinical, cytogenetical, histological and endocrinological features of this syndrome are described from an andrological point of view, including the evaluation of the spermatogram. As there are no typical clinical features for the XX-male syndrome, and the sex-chromatin is positive in Klinefelter's Syndrome also, it is necessary to use the chromosome-analysis for the diagnosis of this rare gonosomal aberration.
Adolescent↗