Nutrients as modulators of immune function.
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Biomedical subjects
Publications and source records attributed to H R Hegde.
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Human immunodeficiency virus, the retrovirus associated with acquired immunodeficiency syndrome, is known to deplete CD4+ helper cells and reduce CD8+ cytotoxic cell activity, resulting in impaired cell-mediated immunity and a 'state of anergy'. This leads to dissemination of micro-organisms that are normally held dormant in the host by the cell-mediated immune system. Malnutrition also leads to depletion of CD4+ helper cells and decreases CD8+ cytotoxic cells leading to impaired cell-mediated immunity and 'state of anergy'. Clinical situation can worsen when the two conditions co-exist.
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We describe two patients with aplasia of the pectoralis major muscle and renal anomalies. We think such an association, which has been reported previously, represents a new congenital malformation, probably not a syndrome but an acro-pectoro-renal field defect. We recommend renal ultrasonography be done on all children with aplasia of the pectoralis major.
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