Anergy, AIDS and tuberculosis.

H R Hegde

doi:10.1016/0306-9877(95)90217-1

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Anergy, AIDS and tuberculosis.

H R Hegde

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Abstract

Human immunodeficiency virus causes an immunological 'state of anergy'. This state is due to a defective function of antigen-presenting cells, a depletion of CD4+ helper cells, a reduction in the production of soluble factors required for signal transduction, and a decrease in cytotoxic cell activation. The human immunodeficiency virus epidemic has resulted in a global resurgence of tuberculosis. Tuberculin skin testing is negative in 58% of the patients with acquired immunodeficiency syndrome who develop tuberculosis. The mechanism leading to a state of anergy and the mechanism leading to dissemination of dormant tuberculosis appear to be identical.

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H R Hegde. 1995. Anergy, AIDS and tuberculosis.. https://doi.org/10.1016/0306-9877(95)90217-1

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