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Biomedical subjects

H Roux

Publications and source records attributed to H Roux.

At least 91 records · Page 5Linked to original sources
PubMed1981

[T and B lymphocyte subpopulations with HLA-DR surface molecules in rheumatoid arthritis, using a monoclonal lymphocytotoxic antibody. Poorly and highly developed rheumatoid arthritis].

The T and B lymphocyte subpopulations were studied in 46 patients with rheumatoid arthritis using a monoclonal anti I-E/CK antibody produced by cell hybridation. This antibody recognized HLA-DR "cross-reactive" molecules on the lymphocytes it attacked. The percentage of T cells which were HLA-DR positive was not significantly raised. Taking into account the fall in the T lymphocytes seen in the course of rheumatoid arthritis, the proportion of this sub-population does not seem to be altered when taking the overall picture into account. Similarly the B lymphocytes do not seem to be significantly altered. Nevertheless the heterogeneity of the levels found in all the DR positive sub-populations allows us to suppose that rheumatoid arthritis as we recognize it contains immunologically distinct entities.

Acute Disease↗
PubMed1981

[Immunofluorescence of the synovial membrane. Study of 100 cases].

A study of the use of immunofluorescence of synovial membranes in one hundred cases of various arthropathies reveals the value of the cytoplasmic localization of immune deposits and their type (Ig) in orienting the diagnosis, the influence of therapy, the lack of correlation with optical anatomopathology of synovial tissue (performed on another tissue fragment). Certain recurrent images such as fluorescence of blood vessel walls or the presence of fibrin are of little interest; other such as the cytoplasmic fluorescence of infiltrating cells and particularly, IgG-IgM mixed cellular fluorescence or coupled fluorescence-cellular with Ig and interstitial granular with Ig and C3 orientate the diagnosis to RA. Immunofluorescence appears to be of interest for inflammatory monoarthritis and probable RA. It is less interesting when the etiological context is limited. In addition, a negative immunofluorescent study does not rule out any diagnosis.

Arthritis, Rheumatoid↗
PubMed1979

[Study of the allogenic reactivity and suppression function of lymphocytes, in rheumatoid polyarthritis treated with cold salts, in mixed lymphocyte cultures].

In a group of 30 rheumatoid polyarthritis treated with gold salts, a determination of the T lymphocytes (sheep red cells) furnished in percentage normal values, and in absolute value a normal average value, with, however, a low level of T lymphocytes. In autologous lymphocyte cultures no spontaneous increase of DNA synthesis was registered. The allogenic response was normal, and in mixed culture with the addition of a third type of cells, a discrete specific suppressive activity appeared.

Adult↗
PubMed1979

[Study of circulating fatty globules by filtration of the serum in primary osteonecrosis of the femoral head].

The authors carried out in a group of 21 aseptic osteonecroses of the femoral head, a study of circulating fatty globules using a filtering technique on a millipore filter. 7 of these patients showed a normal lipid count, 10 had isolated increases of the prebetalipoproteins, 2 had a type IV hyperlipemia, 1 a type III hyperlipemia, and 1 a global hypolipemia. In all cases, no fatty globules were found. Decreases in the level of triglycerides and prebetalipoproteins were noted after filtering but the differences were not significant. These observations do not add support to the theory of fatty microembolism of aseptic osteonecrosis of the femoral head.

Adult↗
PubMed1978

[Anatomical study of the lumbosciatic area].

This study of 75 anatomical specimens and their comparison with contrast metrizamide radiography of the terminal dural sac reveals the exact topography, height, volume and morphology of the dural sheath and for the nerve roots their disposition in the terminal sac, the level of the root emergence and anatomical and radiological views of the foramina above and below the emerging roots.

Cauda Equina↗
PubMed1977

Psoriatic arthritis and HLA antigens.

HLA groups including the characteristics of 25 antigens were determined in 108 patients suffering from psoriatic arthritis. These included 18 patients with central forms (pelvospondylitis), and 90 patients with peripheral forms (polyarthritis with or without sacroiliitis). Analysis of the results leads to the following conclusions: central psoriatic arthrisis is strongly associated with B27 and BW38, less closely with B13 and slightly with BW17. Peripheral psoriatic arthritis has the same relationship with the HLA system as has psoriasis without arthropathy.

Arthritis↗
PubMed1977

[Cellular immunity in rheumatoid arthritis. Effect of therapy].

In 89 cases of rheumatoid polyarthritis the number of B lymphocytes was shown by an immunofluorescence technique and the number T lymphocytes by a rosette test. 30 untreated polyarthritics were distinguished into two groups: in one there was no change in the number of T cellules; in the other there was a reduction in the number of T cells and lymphopenia. The same differences were found under corticotherapy (10 cases), antimalarial drugs (8 cases), penicillamine (21 cases), chrysotherapy (11 cases) and levamisole (9 cases). Levamisole only infrequently increases the number of T cellules (2/9). No relation with any developmental parameter was found in any group.

Antimalarials↗
PubMed1976

[Rheumatoid arthritis and trauma. 5 cases].

The authors report 5 cases of post-traumatic rheumatoid polyarthritis. After the traumatism had initiated the first stages of ordinary inflammation, chain reactions, perhaps by means of an "immune" field, intervened to transform it into a self-maintained rheumatoid inflammation. In fact, the etiopathogenic problems of post-traumatic rheumatoid polyarthritis have not yet been elucidated and it cannot be said either that the question of legal compensation for it is any nearer solution. The growing importance of traumatisms in everyday life and of compensation for them, and the gravity of the condition and its disabling sequelae require that great caution should be exercised in the search for criteria for attributing the disease to the traumatism: the almost indefinite evolution of the disease with time makes the choice of the consolidation date arbitrary.

Accidents, Occupational↗
PubMed1976

[Biological exploration of Paget's disease].

The laboratory investigation of cases of Paget's disease has revealed results of three types :--small increases in the sedimentation rate, in the ceruloplasmin level, in the average corpuscule volume, and in uricaemia. These changes are of little practical value;--a considerable increase in the common stocks and in the turn-over of calcium, a frequently negative assessment with a parathyroid hormone level at the lower limit of normality. The levels of calcaemia and calciuria, little changed on average, may increase slightly after hospitalization. The use of these parameters is valuable but they are sometimes difficult to interpret;--an increase in the levels of alkaline phosphatases and of urinary hydroxyproline, in relation to the extent and the activity of the disease, and also of certain parameters of calcium-45 and of quantitative histology. A statistical study of the spontaneous evolution of hydroxyprolinuria in 50 patients with Paget's disease who were not treated for less than 3 years, allowed the authors to establish in what conditions a change induced by calcitonin or mithramycin is significant.

Acid Phosphatase↗
PubMed1976

[Cyclical chemotherapy of myeloma with cell synchronization: therapeutic trial. Apropos of 13 cases].

The authors report the results obtained from the treatment of 13 cases of myeloma by cyclic chemotherapy (melphalan) applied after cellular synchronization with vincristine. The clinical results (maximum 2 years after treatment) were good in 11 cases out of 13. The following laboratory values quickly returned to normal: sedimentation and calcaemia, but there was little change in the immunoglobulins.

Aged↗
PubMed1976

[Early isotopic synoviorthesis during rheumatoid polyarthritis (RP)].

The authors report the results of 1258 chemical synovectomies carried out in subjects with rheumatoid polyarthritis on joints at Steinbrocker stage I and of 470 chemical synovectomies carried out during the first year of evolution of rheumatoid polyarthritis. Comparison with the results of chemical synovectomy carried out later demonstrate the superiority of early chemical synovectomy.

Arthritis, Rheumatoid↗
PubMed1976

[Experimental study of the synthesis of lysosomal enzymes by the synovial membrane: acid phosphatases].

In a system consisting of synovial samples taken surgically and maintained in culture, the authors studied the regulation of enzyme synthesis by taking acid phosphatase as the test enzyme. By means of double labelling and the use of protein synthesis inhibitors, they were able to demonstrate that this synthesis was stimulated by the addition of rheumatoid factor to the culture medium and that it depended on the transcription activity of the genome and on the translation of the information molecules.

Acid Phosphatase↗