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Biomedical subjects

H Säuberli

Publications and source records attributed to H Säuberli.

At least 55 records · Page 3Linked to original sources
PubMed1976

[The value of endoscopic retrograde cholangiopancreatography in negative or undetermined cholecystocholangiography].

In 299 patients with negative cholecystocholangiogram, endoscopic retrograde cholangio-pancreatography (ERCP) was performed. In obstructive jaundice ERCP is the method of choice, while in cholestasis it is indicated if the intravenous cholecystocholangiogram is insufficient. In unclear abdominal conditions and in "postcholecystectomy syndrome" ERCP may be carried out after other abdominal diseases have been ruled out.

Cholangiography↗
PubMed1976

[Ethiology and treatment of pleural empyema after thoracic surgery (author's transl)].

Between 1961 and 1974 a total of 29 patients have been treated for empyema after lung resection. Pneumonectomy for bronchus carcinoma had been previously performed in 19 patients, partial resection of the lung in ten. In the majority of cases a technical insufficiency was at last partially responsible for appearance of empyema. Differentiation between empyema after pneumonectomy and empyema in patients with residual lung parenchyma has proved to be of advantage. As to predisposing factors, treatment and prognosis of empyema in cases with residual parenchyma is comparable to regular pulmonary empyema. Empyema after pneumectomy however is different in treatment and prognosis. Irrigation of the infected thoracic cavity either by repeated punction and/or by continous through-drainage is helpful and improves the otherwise poor prognosis.

Adult↗
PubMed1976

The Mallory-Weiss-syndrome: a clinical study of 20 cases.

This is an account of 20 cases of MWS, representing 8% of a series of 247 consecutive upper GI-bleedings. Men above 40 years and persons with severe concomitant disease are specially at risk. The prognosis is rather good, mortality from bleeding being 10%. Surgery should not be undertaken unless all conservative measures, including vasopressin infusion and even Sengstaken-Blakemore tube have been applied. The typical history, a hiatal hernia and alcohol intake are frequently missing. Neither studies of gastric acid secretion nor esophageal manometry disclosed new pathogenic aspects.

Adult↗
PubMed1976

Gastric emptying of organic acids in the dog.

Test meals of 300 ml. of six different organic acids were instilled into the stomach of six healthy mongrel dogs. Citric, acetic, propionic, lactic, tartaric and succinic acid were given in 50, 100, 150, and 200 mN concentrations. 2. During the emptying process, the gastric contents were aspirated and immediately re-instilled at 10 min intervals, and the following parameters were recorded: volume, concentration of the organic anion, pH, hydrogen ion concentration and osmolarity. 3. By multiple stepwise regression analysis, the combination of parameters which most effectively determines gastric emptying rate was found to be: concentration of the organic anion, followed by intragastric volume and number of previous test meals given on the same day. These three parameters appear in the equation for gastric emptying rate in which the individual characteristic of each acid is expressed by a constant. 4. Among the various acids, inhibition of emptying rate increases with rising number of carboxylic groups of the acid and its molecular weight. 5. After proximal gastric vagotomy, emptying rate of organic acids is independent of volume, and emptying approaches an exponential pattern. 6. A model for gastric emptying of organic acids with at least three different receptors is proposed: one for the structure of the organic acid, one for concentration and one for intragastric volume.

Acetates↗
PubMed1976

The place of gastrin determination in ulcer surgery.

This paper is concerned with the place of gastrin determination in ulcer surgery. Only the acid-stimulating properties of gastrin are considered. The role of the vagus in the gastrin response to a test meal was investigated in patients with duodenal ulcer. 50 patients were studied before and 3, 6, and 12 months after highly selective vagotomy without (25 patients) and with Wnagensteen-pyloroplasty (25 patients). Basal and stimulated gastrin concentration in serum, as determined by radioimmunoassay, were higher 3 months after the operation and 3h after the test meal gastrin levels were still 50% higher than the basal levels. No difference was found between the patients treated with highly selective vagotomy and the patients treates with HSV and additional pyloroplasty. 6 and 12 months after the operation a moderate decrease of gastrin secretion was observed, but basal as well as stimulated levels were still elevated after 12 months compared to the values before operation. Our results indicate that the pattern of gastrin secretion changes as time passes after highly selective vagotomy with or without additional pyloroplasty.

Duodenal Ulcer↗
PubMed1976

[Regulation factors of stomach emptying in dogs].

Gastric emptying of organic acids was studied in 6 healthy mongrel dogs. After chronic esophagostomies were performed according to the method of Komarov, a total of 340 test meals were instilled. Each test meal consisted of 300 ml of 6 different organic acids with decreasing molecular weight and different concentrations. After the experiments were achieved, each dog underwent a proximal gastric vagotomy according to the method of Amdrup, and experiments with citric acid were repeated. The results may be summarized as follows: multiple stepwise regression analysis of the data is consistent with a model in which gastric emptying of organic acids is regulated by 3 receptors. The receptors respond to concentration of the organic acid, the actual volume, and the type of acid. The volume receptor is located in the corpus of the stomach because the effect of volume accelerates the emptying rate after proximal gastric vagotomy while the effects of concentration and type of acid remain unchanged.

Animals↗