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Biomedical subjects

H Storch

Publications and source records attributed to H Storch.

At least 73 records · Page 4Linked to original sources
PubMed1976

Penicillin-induced coagulation disorder.

A coagulation disorder was seen after penicillin-G administration (10 million units/day) in uraemic patients and after high-dose penicillin G (40 million units/day) in patients with a normal glomerular filtration-rate (5 patients after cardiac surgery). This disorder was characterised by: prolongation of bleeding-time, appearing immediately after penicillin-G administration and persisting until 4 days after withdrawal of therapy; disturbance of collagen-induced and ristocetin-induced platelet aggregation; increase of antithrombin-III activity; and inhibition of factor-xa activity. The inhibition of factor-xa activity corresponded to that seen after low-dose-heparin prophylaxis. The clinically latent coagulation disorder, when super-imposed upon pre-existing coagulation abnormalities (uraemia, treatment with anti-coagulants) may cause severe bleeding, as observed in 1 patient with acute renal failure on haemodialysis.

Abscess↗
PubMed1976

[Accidental hypothermia--case contribution to the clinical aspects and therapy].

It is reported on the successful treatment of a 60-year-old female patient with extreme accidental hypothermia (body temperature 24 degrees C). Cardiac and pulmonary complications could be commanded by intensiv-therapeutic measures. As interesting findings at the time of hospitalisation are exhibited the Osborn-wave in the ECG (first description in a clinical case), the alkalosis (pH 7.52) and a good diuresis (60 ml/min). The prognosis of the accidental hypothermia depends on the duration of the chilling, the rapid transfer under control of a physician into an intensive therapy facility, optimal control and therapy of cardio-vascular and respiratory system, the time of re-warming and the previous injuries as well as the concomitant diseases. The time of re-warming is of importance especially in asystolia and in ventricular fibrillation, in order to reach the defibrillation threshold of 26.6 degrees C. The forms of re-warming (combination of inner and outer re-warming) are to be chosen individually and according to the possibilities. They do not play the role expected for the prognosis. A repeated examination of the patient described after 14 months showed normal according to age organic functions without late lesions.

Electrocardiography↗
PubMed1975

[Membrane model in the presentation of surface immunoglobulin on human lymphocytes with peroxidase cabeled antibodies].

For the demonstration of B-lymphocytes the direct immune peroxydase technique with anti-human IgM was used. In contrast to the biochemical and immunological controls in 11.1% of 30 normal persons positive membrane reactions could be proved without doubt. A certain distinction from other white blood cells and falsely positive contrast reactions is possible by means of counterstain with genuine nuclear red and after contrastation with osmium tetroxyde. The method described has a large number of advantages compared with other methods of the determination of B-cells, which appear usable for the clinician above all on account of the relevance to practice.

Antibody Formation↗
PubMed1975

[Therapy and prognosis of autoimmune hemolytic anemia].

Of 48 patients with autoimmunohaemolytic anaemia who were treated in our clinic during the last 10 years 13 could fully be cured, 20 exhibited a satisfying improvement, 7 remained without improvement and 8 died (3 of them of the basic disease). The results obtained allow the conclusion that the therapeutic use of corticosteroids, particularly at the beginning of the treatment as well as in the acute haemolytic attack is justified. Cytostatics, however, are especially suitable for long-term therapy, whereas splenectomy should be performed when no sufficient therapeutic success was achieved and in special cases. Under optimal therapy and repeated control the prognosis is to be regarded as favourable. For this reason treatment and further care by a haematological centre are demanded, since in such a facility are the most favourable conditions for the best care of the patients with autoimmunohaemolytic anaemia.

Adult↗
PubMed1975

[Immunodiagnostic methods in lupus erythematosus disseminatus].

In 27 patients with lupus erythematodes diseminatus the determinations of the LE-cells according to the macromethod (Zimmer and Hargraves) and the micromethod (Mudrik and co-workers) were compared with the demonstration of antinuclear factors according to the indirect immunofluorescence and immune enzyme technique. The sensitiveness of the two last-mentioned immunomorphological methods is somewhat larger. In these cases the size of the titre of the antinuclear factor almost always correlates positively with the number of the LE-cells. For the purpose of the initial diagnostics and the judgment of the course a morphological method cannot be renounced, since in the acute episode a high consumption of the antinuclear factor the immunological methods negatively correlate with the number of the LE-cells. The immune enzyme technique is to be recommended on account of the smaller expenditure, permanence of the preparations and high sensitiveness as alternative method of the immunofluorescence technique. In the micromethod the large variation is opposite to the advantage of the slight quantity of blood and to an always existing evaluability. Investigations of the lymphocytes of patients with lupus erythematodes disseminatus by means of the lymphocyte transformation test and the determination of the B-cells with the help of the direct immune peroxidase technique refer to the close pathogenetic connections of cellular and humoral immune reactions in this disease.

Antibodies, Antinuclear↗