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Biomedical subjects

H Takiuchi

Publications and source records attributed to H Takiuchi.

51 records · Page 3Linked to original sources
PubMed1986

Retroperitoneal schwannoma.

A case of retroperitoneal benign schwannoma is presented; in addition, 133 cases of retroperitoneal schwannoma reported in Japanese literature are studied. In our series 66 per cent of the cases were found to be cystic. Therefore, the cystic change may be one of the preoperative features of schwannomas, because other types of retroperitoneal tumor do not frequently form cysts. Furthermore, the necessity of postoperative electron microscopy for accurate histologic diagnosis is discussed.

Adult↗
PubMed1986

Transrectal longitudinal ultrasonography of prostatic abscess.

A definite diagnosis of prostatic abscess sometimes is difficult to make. We report 2 cases of prostatic abscess diagnosed with the aid of transrectal longitudinal ultrasonography by electronic linear scanning. Transperineal aspiration of the abscesses was performed easily and correctly with this echographic technique.

Abscess↗
PubMed1986

[A long ureteral polyp with ureteropelvic junction obstruction: report of a case].

A case of long ureteral polyp with ureteropelvic junction obstruction in a 29-year-old man is reported. He had complained of occasional left flank pain since several years earlier. Excretory urography showed left giant hydronephrosis and no urolithiasis. Retrograde pyelography revealed a mass lesion of the left upper ureter. At exploration, the left ureteropelvic junction was found to be obstructed by an aberrant lower pole renal vessel. At just distal of the junction, a finger-like ureteral polyp, 5 cm in maximal length, was present and accompanied with several little polyps. Partial ureterectomy and pyeloplasty improved the left hydronephrosis. The patient remains symptomless for one year after the operation.

Adult↗
PubMed1986

[Cavernous hemangioma of the bladder: a case report].

A case of cavernous hemangioma of the bladder treated with transurethral resection is presented. A 67-year-old female was admitted to this department with the chief complaint of gross hematuria. At cystoscopy a gray, sessile tumor the size of a grain of rice was found at the left lateral wall. Computed tomography confirmed the observation of the cystoscopy and showed that the tumor did not invade into the muscle layer of the bladder wall. With the preoperative diagnosis of bladder tumor, transurethral resection of the tumor was carried out on March 2, 1984 and the specimen was pathologically diagnosed as cavernous hemangioma of the bladder. Sixty-one cases of bladder hemangioma including this case are reviewed briefly.

Aged↗
PubMed1985

Masculinizing operation for a female patient with congenital adrenocortical hyperplasia due to 21-hydroxylase deficiency.

A 25-year-old female with simple virilizing type of congenital adrenocortical hyperplasia due to 21-hydroxylase deficiency was treated surgically with masculinizing operations which consisted of two-stage procedures. The first procedure was chordectomy associated with excision of both gonads and female internal genitalia. Eleven months later, the second procedure consisting of urethroplasty and implantation of testicular prosthesis was performed. The postoperative course was successful in terms of urination and penile erection.

Adrenal Hyperplasia, Congenital↗
PubMed1985

[Results of the Burch colposuspension operation for female stress incontinence].

Of 48 patients with radiologically proven cystocele, 13 patients were treated with the Burch colposuspension procedure from October, 1980 to August, 1984 in our clinic. A satisfactory result with good urinary control was obtained in 13 cases and the procedure was a failure in one. Partial or complete urinary retention was evident postoperatively in 8 patients (62%), but all of the patients voided satisfactorily within 4 weeks. Radiological diagnosis of the cystocele and advantage of Burch colposuspension procedure are discussed.

Adult↗
PubMed1982

A new antithrombogenic material with long polyethyleneoxide chains.

The PVC-g-MnG polymers were synthesized by photo-induced graft copolymerization of methoxypoly (ethyleneoxide)monomethacrylate (MnG) with various chain lengths (n) of polyethyleneoxide (PEO) (n = 4, 9, 15, 23, 50, 100) as side chains to polyvinylchloride (PVC) with photo-sensitive dithiocarbamate groups. Antithrombogenicity has been evaluated in vitro and in vivo. The in vitro and in vivo results indicated that the adsorption of blood elements to the PVC-g-MnG significantly decreased with the increasing PEO chain length (n). From these findings it is suggested that the volume restriction effect resulted from the formation of long-chain PEO on the surface and which effectively suppresses the adsorption of blood elements and prevents the denaturation of blood elements.

Adsorption↗
PubMed1980

Significance of tryptophan residues in the D-domain of the fibrin molecule in fibrin polymer formation.

The modification of fibrin monomer with H2O2 caused reduction of the association activity of fibrin monomer. The association activity was not reduced even by modification of approx. 16 out of the total 64 tryptophan residues in the fibrin molecule; it was then abolished by further modification of the following several residues. Fragment D obtained by proteolysis of fibrinogen with plasmin, inhibited the association activity of fibrin monomer and the modification of approx. six out of the total 21 tryptophan residues in the fragment led to the complete loss of the inhibitory effect. It was concluded from these studies that about six tryptophan residues in the D-domain of fibrin are important for the association of fibrin monomer.

Chemical Phenomena↗
PubMed1980

True histiocytic lymphoma.

An 86-year-old man had true histiocytic lymphoma of the skin. Diagnosis was established by the following findings: (1) typical histological features, (2) lack of receptors on tumor cells for immunological surface markers, and (3) active phagocytic function. Electron microscopic studies indicated cytoplasmic multivesicular bodies in the tumor cells. Multivesicular bodies have been reported in histiocytic proliferative disorders and may be of diagnostic value in cases of true histiocytic lymphoma.

Aged↗
PubMed1978

Functional consequences of tryptophan modification in human fibrinogen.

When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. These cross-links may be closely associated with oxidation of tryptophan residues. The polymerization activity of fibrinogen with thrombin was decreased markedly by this modification. Modification of tryptophan residues in fibrinogen was also performed with 2-hydroxy-5-nitrobenzyl bromide. Modification of two out of a total 78 tryptophan residues in the molecule with the reagent led to the intensification (1.7 times) of the polymerization activity with thrombin and further modification of the next two residues led to complete loss of the polymerization activity. The first two tryptophan residues to be modified are in Fragment D, and the next two occur in Fragment E.

2-Hydroxy-5-nitrobenzyl Bromide↗
PubMedDate not supplied

Immunohistochemical expression of vascular endothelial growth factor can predict response to 5-fluorouracil and cisplatin in patients with gastric adenocarcinoma.

The combination of 5-fluorouracil (5-FU) and cisplatin is used most commonly for gastric carcinoma. Recent studies have indicated that vascular endothelial growth factor (VEGF) is related to drug delivery through angiogenesis and vascular permeability. In this study, we evaluated the efficacy and toxicity of continuous infusion of 5-FU and low dose cisplatin infusion as first-line treatment in patients with unresectable gastric adenocarcinoma. We also examined the relationship between chemotherapy response and immunohistochemical expression of VEGF in the biopsy samples of gastric primary. All 30 patients enrolled in this study were assessable for response, adverse reactions, and VEGF expression. The regimen consisted of 5-FU (350 mg/m2/day every day by continuous venous infusion) and low dose cisplatin (7 mg/m2/day by drip infusion over 1 h on days 1-5 every week). This treatment was repeated weekly for 3 consecutive weeks. Four weeks after the second cycle, mesurable lesions were estimated for response. An overall response rate was 46.7% (14/30). Patients with intestinal histologic type (10/12) and good performance status ([PS], 13/18) showed good response rate (83.3%, and 72.2%, respectively) compared to patients with diffuse histologic type (4/18) and poor PS [(1/12) 22.2%, and 8. 3%, respectively]. The response rate of VEGF-positive cases and VEGF-negative cases was 75% (12/16), and 16.7% (2/14), respectively. Multivarite analysis revealed that VEGF-positive and good PS had a significant impact on chemotherapy response in this treatment. The most common garde 3 or higher toxicities were myelosuppression (30%) and diarrhea (13.3%). Continuous infusion of 5-FU and low dose cisplatin infusion is an effective treatment for patients with unresectable gastric carcinoma, and VEGF expression may be a useful predictor of chemotherapy response in this regimen.

Adenocarcinoma↗
PubMedDate not supplied

Phase 1/11 study of bi-weekly irinotecan plus cisplatin in the treatment of advanced gastric cancer.

OBJECTIVES: To conduct a phase I/II study of irinotecan with cisplatin to establish a recommended dose, and assess the safety, efficacy and feasibility of this regimen in unresectable advanced or recurrent gastric cancer. PATIENTS AND METHODS: In the phase I portion of the study, patients received a fixed dose of cisplatin (30 mg/m2) with escalating doses of irinotecan, ranging from 30 mg/m2 to 70 mg/m2, on days 1 and 15. In the phase II portion of the study, 40 patients were evaluated for response and safety at the recommended dose. RESULTS: Eighteen patients were enrolled in the phase I study. Dose-limiting toxicity (diarrhea and neutropenia) appeared at the irinotecan dose of 70 mg/m2. Therefore, the recommended irinotecan dose was 60 mg/m2. In the phase II study, 40 patients received cisplatin (30 mg/m2) plus irinotecan (60 mg/m2). Twenty-five out of 40 patients had received prior chemotherapy. The median number of cycles was 3.5. The response rate was 32.5% (13/40) overall, and 53.3% (8/15) in patients without prior chemotherapy. The median time to tumor progression (TTP) was 162 days. The median survival time was 288 days. Four patients (10%) developed grade 4 neutropenia and 3 patients (7.5%) developed grade 4 anemia. The only observed non-hematological toxicity at grade 3 or higher was diarrhea, seen in 2.5% (1/40) of the patients. CONCLUSION: Bi-weekly administration of irinotecan and cisplatin is safe and active for the management of unresectable advanced or recurrent gastric cancer.

Adult↗