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Biomedical subjects

H W Ocklitz

Publications and source records attributed to H W Ocklitz.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Preliminary results of an atiepizootic field test using EDTA-Na extract vaccine from Escherichia coli strains pathogenic to swine in swine production industrial units].

An anti-epizootic field test was applied to industrialised pig farms in the region of Wrocław, Poland, to test the effectiveness of a pentavalent EDTA (calcium disodium edetate)--sodium vaccine extracted from Escherichia coli strains with pathogenicity to swine. The vaccine had been received from a centre in Berlin-Buch, GDR. The vaccine failed to provide any protection, when orally applied to nursed piglets. However, both morbidity and mortality were reduced and, thus, an anti-epizootic effect on nursed piglets produced, when the vaccine had been injected intramuscularly to the pregnant mother animals, prior to farrowing. In weaned piglets morbidity was sucessfully reduced by both oral as well as intramuscular administration.

Administration, Oral↗
PubMed1979

[Rotavirus diarrhea in childhood].

Electron microscopy of 350 diarrhoeal faeces revealed Rotavirus-particles in 145 cases. All patients with Rotavirus-infections showed symptoms of acute gastroenteritis lasting 1 to 8 days. Additionally to diarrhoea most cases presented fever and vomiting. None of the patients showed toxicosis.

Child↗
PubMed1979

Vaccinations against bacterial infections.

1. As with any therapeutic measure, prophylactic vaccination is to be jugded by the correlation between benefit and harm or expenditure. By benefit is meant a not to short-lived substantial decrease in the morbidity and/or mortality. Harm refers to the number and severity of side effects in the individual child vaccinated and expenditure means the economic burden placed upon society. 2. The evaluation of many vaccinations at present varies between two extremes: On the one hand vaccination procedures are considered to provide an opportunity to eradicate most of the infectious diseases, on the other hand there is a tendency to assess side effects more drastically the more likely the danger of the particular disease seems eliminated once and for all. 3. An attempt is made to discuss the achieved or achievable standard of vaccination measures against bacterial infections in the light of 3 classes of vaccines. The first class involves well established and commonly used vaccines such as BCG and DPT vaccines although differences in opinion exist on their future employment. 4. The second class involves newer vaccines or vaccines that are under development as for instance vaccines against meningococci, pneumococci, H. influenzae and enteropathogenic E. coli. 5. The third class includes vaccines whose realisation at present appears to be yet difficult or hardly feasible, for instance vaccines against enterotoxins of enteropathogenic organisms, against lues, gonorrhea or for example against organisms of the infectious hospitalism.

Animals↗
PubMed1979

Vaccinations against bacterial infections.

The achieved or achievable standard of vaccination measures against bacterial infections is discussed with reference to 3 groups of vaccines. The first group involves well established and commonly used vaccines such as BCG and DPT vaccines. The second group includes newer vaccines or vaccines that are under development, for instance vaccines against meningococci, pneumococci, H. influenzae and enteropathogenic E. coli. The third group covers vaccines whose realisation at present appears to be difficult or hardly feasible, for instance vaccines against enterotoxins of enteropathogenic organisms, against lues, gonorrhea or, example, against organisms of hospital infections.

Adolescent↗
PubMed1978

[Laboratory experiments with a polyvalent extract vaccine for oral immunization against E. coli enteritis].

Bacteria of E. coli causing enteritis can be extracted by EDTA-sodium. These extracts having lower dry weights result in better protective effects in contrast to sodium-deoxycholate extracts. The EDTA-sodium extracts can be concentrated, purified and sterile filtrated. Thus the production of polyvalent vaccines is possible. A direct relation exists between the effectiveness of the extracts and the virulence of the strains used for extraction. The more virulent the original strain the better is the protective effect of the vaccine produced by extraction of the original strain. The single components of the polyvalent vaccine show a certain improvement of their protective effects. For estimating the immunizing dose, it is necessary to consider the limiting dose. When exceeding this dose the protective effect or the vaccine does not further increase but remains constant of even decreases. The immunizing dose wanted must be greater than the ED50 but smaller than the limiting dose. Extremely high oral doses of vaccine result in symptoms of incompatibility in mice.

Administration, Oral↗
PubMed1976

The measles eradication programme in the German Democratic Republic.

After 3 years of intensive preparations the Ministry of Health of the German Democratic Republic started a national measles eradication programme in 1967. Vaccination was at first voluntary, but became compulsory in 1970. Through a vaccination campaign using Leningrad-16/SSW attenuated live vaccine, the disease was virtually eliminated throughout the country by 1972. In 1973 and 1974 only sporadic cases of measles were observed. The number of vaccination failures was negligible. Combined immunization against measles and poliomyelitis provoked no unusual reactions, and the difference between the seroconversion rates following combined or separate immunization was not statistically significant.

Child↗