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Biomedical subjects

H Winkelmann

Publications and source records attributed to H Winkelmann.

At least 19 recordsLinked to original sources
PubMed1993

[Embolization of cerebral arteriovenous malformations--methods and clinical results].

Interventional treatment by neuroradiological embolisation of cerebral arteriovenous angiomas has become an alternative to surgical exstirpation especially in problematic localisations and large-size malformations. Clinical results showing a marked reduction in attacks and recurrent haemorrhages, evident from a three-year report on 17 patients, confirm the value of the method even in case of only subtotal occlusion of the malformation.

Brain Neoplasms↗
PubMed1993

Problems in the balloon occlusion of aneurysms.

From 1987-1991 we performed 20 balloon occlusions in 15 patients with intracranial aneurysms. In 9 patients procedures were technically successful however long term complications included three deaths. In spite of the advancements in the balloon catheter technology fatalities occur restricting the use of percutaneous balloon occlusion to patients with unclippable aneurysms.

Adult↗
PubMed1991

Stigmata of atopic constitution in patients with atopic eczema or atopic respiratory disease.

In the diagnosis of atopic eczema, minor physical markers (stigmata) frequently provide valuable clues. The prevalence of nine stigmata (dry skin, hyperlinearity of the palms or soles, infraorbital fold, white dermographism, facial pallor, orbital darkening, Hertoghe's sign, low hairline) was evaluated in 34 atopic eczema patients without atopic respiratory disease, in 16 patients with allergic rhinitis and/or asthma without atopic eczema, and in 23 controls without atopic respiratory or eczematous disease, and with negative results at prick testing with three common aeroallergens. Compared with controls, all features except Hertoghe's sign were significantly (p less than 0.01) more frequent in atopic eczema, and, except for Hertoghe's sign, dry skin and white dermographism, they were significantly (low hairline, p less than 0.05; others, p less than 0.01) more frequent also in respiratory disease. The prevalence of most stigmata did not differ significantly (p greater than 0.05) in cutaneous vs. respiratory atopic disease, only dry skin being more frequent in atopic eczema (p less than 0.05). Although not specific, most stigmata are characteristic markers not only of atopic eczema, but of atopy as such.

Adolescent↗
PubMed1991

[Carbon disulfide excretion in urine--a biological exposure test for the workplace and environmental concentration ranges].

The biological control procedure for carbon disulphide (CS2), the determination of free and bound CS2 in urine--a procedure already applied to hygienic surveillance--were modified by using gas chromatography and sulphide selective detection (FPD). The results obtained by the changed biological monitoring test in workplace and environmental surveillance are present and discussed. For CS2 concentrations at workplaces in the range of 8-54 mg/m3 a correlation coefficient of r = 0.56 (n = 11, p less than 0.07) was calculated for the mathematical connection of CS2 shift exposure and CS2 content in urine. For environmental exposures in the range of the CS2 immision short term threshold value (MIKK) of 0.03 mg/m3 the procedure may discriminate significantly exposure load from naturally occurring CS2 background.

Adult↗
PubMed1990

[Serum proteins levels of school children in areas with variable air pollution, especially by carbon disulfide (CS2)].

Within an epidemiological transversal study concerning the effect of CS2 immissions on the health state of school children during 1987/1988, 340 9 to 10 years old children (198 exposed, 142 non-exposed) have been investigated. From a venous blood sample 12 serum proteins have been determined, among other determinations. From these 12 immunological parameters, relating the mean concentrations of them in connection to the two different areas 7 were significantly different, 2 probably different, and 3 had no differences (T-test). These results are discussed in connection with other data from the literature.

Acute-Phase Proteins↗
PubMed1990

[Development and application of an environment dosimeter for carbon disulfide].

Construction, function, and quality of parameters of a newly developed passive dosimeter for carbon disulphide are described. CS2 adsorbed on chromosorb 101 is thermically desorbed and then dosed to a gas chromatograph via a gas sampling valve and finally determined by flame photometric detection (FPD). The dosimeter allows 24-hr immission and indoor measurements, respectively, and is also suitable as a personal dosimeter for the environmental concentration range. First practical measurement results are discussed.

Air Pollutants↗
PubMed1990

[Evaluating guidelines for "selection and training of staff for odor analysis"--a 7-year longitudinal study].

During a 7 years longitudinal study on a representative group the guideline "selection and schooling of personal for odour analysis" was reexamined. It could be shown that the selection in two steps is well suited to recognize anosmia and hyposmia, respectively and that normal osmia is well to be characterized by smell scores of 30-42. A statistical significant training effect could be shown with the qualitative test for training of the odour memory as well as the articulation in describing of smell impressions. The result of the rank order test demonstrate the practicable subdivision of the odour intensity into 5 degrees.

Humans↗
PubMed1990

[Exposure analysis of the effect of air pollution by carbon disulfide].

In the framework of an epidemiological cross sectional study on the medical effects of environmental carbon disulphide loads a specific exposure analysis has been developed concerning this harmful substance. The main point of this analysis is the determination of the individual exposure by personal sampling and biological monitoring, respectively, in addition to emission and in-door measurements. The non-metabolised and acid labile CS2 in urine is determined as the specific biological marker. For characterizing the additional exposure the drinking water, soil, and settlement structure were investigated. Since 1987 this expensive analysis is performed parallel to a specific medical examination programme.

Air Pollutants↗
PubMed1990

[A program of medical examination of the effect of air pollution by carbon disulfide].

For investigating the effect of emissions of the cellulose and rayon silk production on the health state of selected groups of the population as part of an epidemiological cross sectional study on 9-year old school children a medical examination programme with emphasis to the following 5 points--psychological examination, clinical-chemical investigations, lung function analysis, actual state, anamnestic inquiry--has been developed. The programme has been successfully tested in 660 specifically exposed and non-exposed children, respectively. Hitherto performed part evaluations of the mentioned 5 points confirm the correctness of the broadly constructed study.

Air Pollutants↗
PubMed1990

[Development of a city planning hygiene analysis and its application in the framework of an environmental-epidemiological study].

A "town-planning hygienic analysis" is presented which has been developed within an environmental epidemiological study. This analysis contains 7 marks (maximum sound pressure level Lmax, equivalent pressure level Leq, housing conditions/sanitary, size of flat, brightness/day-light ratio, environment, building order) whose quality is scored into 3 categories (very good/good, sufficient, insufficient). The evaluation is performed by relating the frequency of the proportional quality as well as the score for the general quality, which is constructed by the mean of the proportional qualities. First results are discussed with a comparative study on 297 flats.

City Planning↗
PubMed1989

[Teratogen-modified palatogenesis in the Uje: WIST rat. 4. Scanning electron microscopic morphology of the epithelium during the formation of the secondary palate].

In normal morphogenesis age-dependent and regional differences in the surface structure of epithelial cells appear, whereas in teratogenesis no qualitative changes can be observed. During the horizontal adjustment of the palatal shelves the pronounced marking of the cellular borders with microvilli has disappeared. The reduced number of microvilli in the subsequent phase of adhesion might affect the cell-cell identification and thus disturb the further cell differentiation.

Animals↗
PubMed1989

[CT-guided puncture biopsies of cystic processes in the cerebral and spinal areas].

Cystic space occupying processes are well imaged by CT because of their low density. For localization and identification of the surrounding brain structures additional coronary or secondary cuts can be used. Measurements of distances and angles from the intended point of puncture allow, with an appropriate technique, a free-hand puncture of the cyst. Needle position must be recorded with CT-images. No complications occurred in 22 patients. Punctures of cysts have only a symptomatic and transient effect. The immediate pressure reduction and the improvement of the clinical condition of the patient, however, can be valuable as an intermediate measure before surgery.

Biopsy, Needle↗
PubMed1988

[Interventional radiology in neurosurgery--on the use of endovascular balloon occlusion].

A report is given on our experience gained in the introduction of the method of detachable microballoon catheters in the sense of the intervention neuroradiological operative technique. Twenty patients with arteriovenous angiomas, bag-like aneurysms, a carotid Sinus vernosus fistula and intracranial tumours rich in blood vessels were treated according to this method. Adjoining procedures such as embolisation are discussed.

Arteriovenous Fistula↗