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Biomedical subjects

H Wirth

Publications and source records attributed to H Wirth.

At least 37 records · Page 2Linked to original sources
PubMed1992

Indication for using extracorporeal membrane oxygenation in congenital diaphragmatic hernias and pulmonary hypoplasia.

Despite the apparent surgical simplicity of the anatomic defect, congenital diaphragmatic hernia continues to be a critical problem in neonatal surgery, so that survival is still uncertain. Therefore, we must realize that the barriers to survival are pulmonary parenchymal and vascular hypoplasia as well as the complex syndrome of persisting fetal circulation. However, new treatment methods, such as extracorporeal membrane oxygenation (ECMO), although controversial, may improve survival. We believe that no infant should be excluded from diaphragmatic repair or consideration for ECMO-support before accurate predictive parameters have been developed that take both pulmonary hypoplasia and pulmonary hypertension into account. ECMO additionally enables us to postpone the operation until stabilization of the newborn (Late Operation Protocol). Apart from this, we can probably improve the long-term results after ECMO by reconstructing the common carotid artery.

Combined Modality Therapy↗
PubMed1992

Immunohistochemical localization of carbonyl reductase in human tissues.

Carbonyl reductase, an NADPH-dependent oxidoreductase of broad specificity, is present in many human tissues. Its precise localization, however, has remained unclear, as well as its physiological and possible pathophysiological significance. The present study reports the immunohistochemical localization of the enzyme in normal human tissues. Immunostaining was detectable in all organs investigated. The highest concentrations were found in the parenchymal cells of the liver, the epithelial cells of the stomach and small intestine, the epidermis, the proximal tubules of the kidney, neuronal and glial cells of the central nervous system, and certain cells of the anterior lobe of the pituitary gland. Consistently pronounced staining was also observed in smooth muscle fibers and the endothelium of blood vessels. The results are in agreement with a housekeeping function of carbonyl reductase in the elimination of reactive carbonyl compounds.

Adrenal Glands↗
PubMed1986

The adsorption of hexachlorobenzene on naturally occurring adsorbents in water.

To evaluate the distribution of hexachlorobenzene (HCB) between water and natural adsorbents, laboratory experiments were performed with 14C-labelled HCB, with quartz, kaolinite, illite, bentonite, peat, suspended particulate matter and activated sewage sludge as the natural adsorbents. HCB was bound mainly to organogenic adsorbents with distribution coefficients between 140 (for bentonite) and 28,000 (for activated sewage sludge). Desorption experiments showed that distilled water could remobilize up to 100% HCB from mineral adsorbents, but only 3% from activated sewage sludge. Using these values, basic parameters for the bioavailability of HCB in natural waters were estimated.

Adsorption↗
PubMed1983

[Modification of sebaceous gland secretion by the antiestrogen tamoxifen in female and male golden hamsters].

24 male and 24 female syrian hamsters were treated with antiestrogen Tamoxifen for 21 days (dosage 5, 50, 200 and 800 microgram/d, respectively). For control, 6 male and 6 female animals remained untreated. After having finished this treatment, we performed double-labelling autoradiography with 3H- and 14C-thymidine on all animals, under in vivo-conditions. The number of single labelled 3H-cells has been related to cell proliferation. The quotient " double labelled cells/single 3H-labelled cells " served as a measure for the duration of the S-phase. In addition, we measured the sebaceous gland volume. No essential influence on the parameters could be found. Therefore, we have to assume that the antiestrogen Tamoxifen does not have an essential effect on cell kinetics in the sebaceous gland.

Administration, Topical↗
PubMed1983

[Phenytoin therapy in recessive dystrophic epidermolyses (epidermolysis bullosa dystrophica type Hallopeau-Siemens and epidermolysis bullosa dystrophica inversa)].

In epidermolysis bullosa dystrophica recessiva Hallopeau-Siemens, blister formation is due to an excessive synthesis and secretion of a genetically altered collagenase which, under mechanical trauma, becomes activated out of its pro-enzyme and leads to the destruction of collagen in the papillary dermis. There is evidence that phenytoin can inhibit the production of collagenase in the fibroblasts. This paper reports on experiences with the treatment of 6 patients suffering from this epidermolysis bullosa type with phenytoin since 2 years and more. Problems of pharmacokinetics and dosage, possible signs of intoxication, interactions with other drugs as well as side effects of phenytoin are discussed and a therapy regimen schedule is proposed on the basis of these experiences.

Administration, Oral↗
PubMed1983

[Effect of the treatment of psoriasis with dithranol in comparison with a combination of dithranol and a corticosteroid].

Symmetric lesions of ten psoriasis patients were treated with anthralin and a combination of anthralin and steroid to compare the effect of these two therapies. After treatment, tissue was excised from the papules. An in vitro double-labeling autoradiography with 3H- and 14C-thymidine was then carried out. The thickness of the epidermis was also measured. The anthralin therapy leads to significantly greater inhibition of proliferation than the combined therapy with steroid. On the other hand, the combined therapy significantly shortens the duration of the S-phase, which is pathologically lengthened in psoriasis patients. The combined therapy also leads to significantly greater thinning of the epidermis.

Adrenal Cortex Hormones↗
PubMed1983

[Unilateral linear basal cell nevus].

Clinical, histopathological, electron-microscopical and cytophotometrical features of a case of linear unilateral basal cell nevus are reported. Several publications exist on basaliomas originating in a nevus verrucosus or nevus comedonicus. Our case, however, is regarded as an abortive form of the basal cell nevus syndrome due to somatic mutation. Only some few comparable cases are documented in the literature.

Basal Cell Nevus Syndrome↗