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Biomedical subjects

H Wolff

Publications and source records attributed to H Wolff.

At least 145 records · Page 8Linked to original sources
PubMed1989

[Feasibility and relevance of tumor volumetry for stage classification and assessment of remission of germ cell tumors].

Although tumor load has proven to be the most relevant prognostic factor in disseminated germ cell tumors (GCT), methods to determine tumor volume for staging have not been studied so far. In a prospective study, we therefore measured the volume of metastases before and during chemotherapy in 27 patients with disseminated GCT. Abdominal tumor volume was calculated using a General Electric CT scan 8800. Total volume was determined by cumulation of 1 cm slices measured by a cursor. Pulmonary volume was calculated by taking each metastasis as a sphere using V = 0.523 x d3, where V = volume and d = diameter. We used linear regression analysis to determine the dependence of tumor markers on volume. Before chemotherapy, the median tumor volume of all patients was 237 (range 4-2690) cm3. The tumor volume was 1-100 cm3 in 30%, 101-500 cm3 in 41%, and over 500 cm3 in 29% of the patients. NED (no evidence of disease) was achieved in 8/8 patients presenting with a small (1-100 cm3) and 9/10 with a moderate (101-500 cm3) tumor volume. In contrast, only 1/8 with advanced tumor load (greater than 500 cm3) achieved NED. While there was a significant correlation between the initial and the residual tumor volume (P = 0.0024, r = 0.72), there was none between the tumor volume and alpha fetoprotein, beta human chorionic gonadotropin, and lactate dehydrogenase. These results suggest that radiological determination of tumor volume is a reproducible and accurate staging method.

Adolescent↗
PubMed1989

[A new method of pancreas transplantation with drainage of exocrine secretion through the gallbladder-bile ducts into the duodenum of the recipient].

A new method of intraperitoneal transplantation of the whole pancreas as donor-pancreaticoduodeno/recipient-cholecystostomy is described. The pancreas with duodenal segment is placed into the dorsal peritoneal cavity and the portal vein is anastomosed with the subhepatic vena cava and the long aortic segment of the graft with the distal aorta of the recipient. An anastomosis between the donor's duodenal segment and the recipient's gallbladder ensures exocrine pancreatic secretion drainage.

Animals↗
PubMed1989

[State of the therapy of hemangiopericytoma].

To informations from literature 700 patients with a hemangiopericytoma can be expected globally until the year 1988. Actually there is no uniform therapeutic procedure for this cancer disease. The own therapeutic strategy is represented, successfully applied to three patients: Actually we consider optimal the combination of surgical extirpation with following radiotherapy of the former tumor bed with a minimum target dose of 45 Gy to guarantee a total remission and a long-time survival.

Adult↗
PubMed1989

[HIV in sperm].

HIV in the semen is located in the mononuclear cell fraction, which contains CD4 lymphocytes and monocytes/macrophages, i.e. the classic HIV host cells. In addition, HIV is also present in cell-free seminal fluid. The results on HIV binding to spermatozoa are still controversial. Genital tract infections are a possible cofactor that might increase the risk of HIV transmission by way of the semen, because they lead to a marked increase in the number of potential HIV host cells in semen.

HIV Infections↗
PubMed1989

[Initial results of a new method of pancreatic transplantation].

A new method of intraperitoneal transplantation of the whole pancreas as donor-pancreaticoduodeno/recipient-cholecystostomy is described. The pancreas with duodenal segment is placed into the dorsal peritoneal cavity and the portal vein is anastomosed with the subhepatic vena cava and the long aortic segment of the graft with the distal aorta of the recipient. An anastomosis between the donor's duodenal segment and the recipient's gallbladder ensures exocrine pancreatic secretion drainage.

Anastomosis, Surgical↗
PubMed1989

[Experiences with CT-guided percutaneous drainage of pyogenic liver abscesses].

32 CT-guided percutaneous drainages of bacterial liver abscesses in 25 patients accomplished definitive sanitation in 18 of them (72%). In 7 cases surgical revision was required. Percutaneous drainage of abscesses was able to achieve a temporal improvement in these cases and therefore was an effective pre-surgical measure. There were no complications primarily due to the method itself. The average dwell-time of catheters during drainage of curative percutaneous drainage was 22.5 days. The new therapy concept has proven to be of little discomfort and complications together with high therapeutic effectiveness.

Adult↗
PubMed1989

[Experiences with intra-arterial tumor chemotherapy of malignant liver tumors via totally implantable catheter systems].

Locoregional chemotherapy was applied to 30 patients for isolated, surgically not removable liver tumours (13 colorectal carcinomas, 17 carcinomas on different sites). Ten patients were in Stage I, 16 in Stage II, and four in Stage III. Cytostatics were administered through totally implantable catheter systems. The following therapeutic protocol was mainly used: 5-flourouracil 800-1,000 mg/m2/3hr/die X 5 in 22 days, adriamycin 30 mg/m2/3 hr/die X 2 in 22 days. The average time of treatment amounted to ten months. Cytotoxis side effects were of minor importance. Hepatic side effects, such as chemical hepatitis or sclerosing cholangitis, were not recordable. Reduction of tumour size by 50 percent or more was recorded by computed tomography from 14 cases (46.6 percent). The objectivated rate of responsiveness in patients with colorectal carcinoma was 61.5 percent. The average period up to progression amounted to 12.1 months. Premortal spreading of the disease beyond the liver was recorded from six patients.

Antineoplastic Agents↗
PubMed1989

[CT and MRT--their influence on surgery].

The introduction of new pictorial methods in the last decade and the increase of information for the surgeon have brought about changes not only in several therapeutic concepts but also in the indications for surgery and in surgical strategies. The influence of CT and MRT on surgery can be summarized in 3 points: 1. Substitution of previous forms of surgical therapy by interventional radiology. Examples are curative CT-guided percutaneous puncture and drainage of abscesses of the liver and other organs. 2. Improved diagnostics and follow-up of acute morphologic processes with non-correlating clinical signs, as acute necrotizing pancreatitis allows a better definition of the therapeutic concept. 3. Advances in tumour surgery by early detection of malignant processes and improved follow up after surgery for the early detection of recurrences and metastases.

Humans↗
PubMed1989

[Stage-dependent approach to stomach cancer].

Accurate staging by unambiguously defined, comparable criteria is essential for a phase-adjusted therapeutic concept to cope with gastric carcinoma. Decision-making on gastrectomy or subtotal gastric resection has to depend primarily on tumour localisation and prognosis by histological classification according to Laurén. Between January 1, 1980, and May 1, 1988, operations for gastric carcinoma were performed on 203 patients at the Surgical Department of Charité, with gastric resection being applied to 144 of them. Postoperative lethality amounted to nine per cent. Indications were established in 66 cases for gastrectomy and in 78 patients for subtotal gastric resection. Two-year survival rates were 52 per cent for the intestinal cell type and 35 per cent for the diffuse type. Prognosis can be improved by radical resection and extensive lymph node removal at the first two lymph node stages. Resection of other infiltrated organ regions may quite often prove necessary for oncological radicality. Splenectomy will be chosen for stomach carcinomas localised in the upper and medium thirds or in tumour stages III and IV.

Adult↗
PubMed1989

[Surgical therapy of thyroid cancer].

There are controversial views and discussions on surgical treatment of thyroid cancer. A retrospective study covering the period from 1979 through 1988 has been conducted by the authors to analyse resective approaches to thyroid cancer. Operations were performed on papillary carcinoma in 37.6% and on follicular carcinoma in 31.8% of the cases. An overall five-year survival rate for differentiated thyroid cancer was recorded from 81.5%, with 100% in stage T1N0M0 (microcarcinoma) according to publications. Hence, much less radical procedures like hemithyroidectomy is fully supported by the authors for microcarcinoma. The total thyroidectomy only should be applied to differentiated thyroid cancer in the advanced stages, to medullary and anaplastic carcinoma.

Adenocarcinoma↗
PubMed1988

Influence of red cell surface charge on red cell membrane curvature.

The wellknown biconcave shape of resting RBC reflects an intrinsic overall negative spontaneous membrane curvature. It depends to a high degree on the integrity of the spectrin-actin-ankyrin-Band-3 hetero-complex. Alterations of this complex have previously been shown to be associated with shape transitions, which have been abolished by treatment with enzymes reducing the surface charge of the RBC. In this report we show that treatment of erythrocytes with enzymes reducing the surface charge (e.g. neuraminidase, trypsin, chymotrypsin and pronase), consistently exerts a "stomatocytogenic" effect, i.e. it reduces mean mean curvature. Also the time dependency for the charge reduction and for the correlated decrease of mean mean curvature is shown. So-called stomatocytogenic agents (e.g. clorpromazine, tetracain and triton X100) and so-called echinocytogenic agents (e.g. dinitrophenol and Na-salicylate) are known to change membrane curvature in a dose dependent manner. It is further shown that by prior reduction of surface charge by various enzymes the dose response curves of all stomatocytogenic and echinocytogenic agents tested is shifted towards higher degrees of stomatocytosis or lesser degrees of echinocytosis. The data show, that in RBC pronounced curvature influences are produced by the surface charge located on the sialic acid residues in the glycocalix.

Electrophysiology↗
PubMed1988

Determination of sperm antibodies in human genital secretions by an ELISA technique.

Sera and genital secretions of 178 infertile men and 40 infertile women were evaluated for antibodies against spermatozoa by an enzyme-linked immunosorbent assay (ELISA). It was shown that circulating sperm antibodies are not usually transudated into genital secretions and, on the other hand, that local antibodies found in cervical mucus or seminal plasma are not detectable in serum. Furthermore it was demonstrated that the solubilization of cervical mucus by bromelain almost completely removes antibody activities detectable by ELISA, whereas sonication of mucus does not affect the immunoglobulins. Sonication should thus be applied for liquefaction of cervical mucus in order to assess its antibody properties.

Antibodies↗
PubMed1988

[Pancreatic duct occlusion in resection treatment of chronic pancreatitis and cancer of the head of the pancreas. A 3-year follow-up study].

The original aims of pancreatic duct occlusion (PDO) were reduction of early complication rate after pancreas resection, influence on clinical symptoms by elimination of exocrine tissue and preservation of B-cell function in the remaining pancreas. As a result of a 3-years study in patients with chronic pancreatitis and carcinoma in whom a Whipple's operation with and without PDO had been carried out the evaluation of PDO was estimated. The PDO has a high value in pancreas head resections because of carcinoma. Similar is the importance in the reduction of clinical symptoms in patients with chronic pancreatitis. A protective effect could not be observed neither in patients with chronic pancreatitis nor with carcinoma. On the other hand there was no additional damage by PDO, as the comparison with patients without PDO has shown.

Adenocarcinoma↗
PubMed1988

[Treatment of small cell bronchial carcinoma with reference to stage classification].

There are controversial views and discussions on surgical treatment of small cell lung cancer. A retrospective study covering the period from 1959 through 1983 has been conducted by the authors to analyse resective approaches to lung cancer. A total of 2,039 resections for lung cancer included operations on 354 small cell carcinomas according to the WHO nomenclature. Operations were performed on 265 cases of small cell lung cancer by the end of 1977. These were subdivided by stages, with survival rates being determined. An overall five-year survival rate was recorded from 22.8 per cent of the cases with 43.0 per cent in Stage Ia und 21.4 per cent in Stage Ib. Hence, resection of small cell lung cancer is fully supported by the authors for Stage Ia and is conditionally supported for Stage Ib, whereas complex radiotherapy and chemotherapy should be applied to small cell lung cancer in the advanced Stage II and III.

Carcinoma, Small Cell↗