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Biomedical subjects

H Zöllner

Publications and source records attributed to H Zöllner.

At least 19 recordsLinked to original sources
PubMed2000

Continuous rise of urinary iodine excretion and drop in thyroid gland size among adolescents in Mecklenburg-West-Pomerania from 1993 to 1997.

Improved legislation (1989, 1993), as well as education of the public, are likely to improve the iodine supply for the German population. Children and adolescents will be the first to profit. We investigated thyroid size and urinary iodine excretion in a total of 2906 students aged 10 to 18 in Mecklenburg-West-Pomerania in 1993, 1995, and 1997. The median urinary iodine excretion rose from 73 microg/g creatinine in 1993 to 133 microg/g in 1997. The prevalence of goiter, according to the reference range of Gutekunst, dropped from 33% to 10% over the same interval, and the median thyroid size declined from 11 ml to 6 ml. While only 6% of the test subjects excreted more than 150 microg iodine per g creatinine in 1993, this figure rose to 33% in 1997. The improved alimentary iodine supply is due to the increased use of iodine enriched salt by the food industry, food factories and in common food supply services.

Adolescent↗
PubMed1997

[Increased dietary intake of iodine in young people in Mecklenburg-Vorpommern 1993 and 1996].

We investigated the goiter prevalence and the urinary iodine excretion of 2,109 young people between 10 and 18 years in the district of Mecklenburg-Vorpommern, Germany in 1995/96. The thyroid volume was determined by ultrasound (7.5 MHz), the iodine excretion by a modified cer-arsenit method. The daily iodine excretion as related to the body surface area and the age related creatinine excretion per 24 h were measured. The results were compared with those of a similar study from 1993 in the same region and the same range of age. The goiter prevalence in 1997 amounted to 18.5%. Among the studied persons 3.6% showed one or more nodules within their thyroid gland. The iodine excretion increased from 70 micrograms in 1993 to 95 micrograms in 1997. There were no changes in the individual nutritional habits (especially iodine-containing foods, using iodized salt etc.). We believe that the raised iodine intake is the result of a higher iodine supply in the commercially produced foodstuffs and animal products due to an increased incorporation of iodine in manufacture of food products.

Adolescent↗
PubMed1997

Serum zinc levels and goitre epidemiology in Germany.

Zinc is an essential element involved in many basic biochemical reactions. Animal experiments and clinical data support the hypothesis that in the presence of inadequate iodine supply zinc deficiency may be a stimulus for the development of goitre. Within the framework of a study to record goitre prevalence and iodine supply of Germany we determined the serum zinc levels in 5932 clinically healthy persons. The mean value was 13.1 +/- 1.75 mumol/l. There were no differences neither in age, in sex nor in regional distribution. Furthermore there were no correlations between serum zinc level, thyroid volume and urinary iodide excretion. Only 1% of all cases had low zinc levels (< 10 mumol/l). Older people (> 40 years) with lowered serum zinc levels showed significantly larger thyroids. We conclude that there is no relevant undersupply of zinc and therefore the trace element is not involved in the goitre endemy of Germany.

Adult↗
PubMed1996

[Current state of alimentary iodine deficiency in Germany].

Germany finds itself among the most iodine deficient countries of Europe. Voluntary use of iodized salt constitutes the only goiter prophylaxis. In the last few years, measures such as the opening up of European internal markets, abolition of lac pertaining to the alimentary iodine consumption. Random samples of urine collected from 5932 persons without thyroid ailment, distributed over 32 regions of Germany, were measured for iodine excretion. The median value of iodine excretion was 72.4 micrograms I/g creatinine. Children under 10 years (76.9) and persons over 70 years (80.7) showed a slightly higher iodine elimination than those between 11-70 years (71.9). No differences between the former East Germany and West Germany as well as North, South and middle regions of unified Germany were observed. 55% of the study population presented with iodine values between 50 and 100 micrograms, 19% with lower than 50 micrograms. Only 9% showed sufficient iodine state. The results expose the inadequacy of the voluntary measures to tackle the problem of alimentary iodine deficiency.

Adolescent↗
PubMed1992

[Capillary blood as diagnostic sample in pediatric laboratory diagnosis. Arterio-capillary-venous difference and blood collection technique].

It is preferable to use capillary blood as diagnostic material in paediatric laboratory tests rather than venous blood. The collection of capillary blood makes less demands on the child and is easy in principle. The objection to capillary blood primarily concerns differences in the analyte concentration in arterial, capillary and venous blood. Comparative studies in the same child under standardised conditions are not available for a number of parameters. However, according to the results available at present, for almost all routine clinical chemical and haematological examinations clinically usable results can be obtained. Using the example of total protein analysis for the same child we did not find any differences between arterial and venous blood. It is highly probably that the same would apply to many other components. Suspected differences are probably a result of short-comings in the collection technique.

Blood Chemical Analysis↗
PubMed1991

[Relative parathyroid insufficiency in hypomagnesemia].

In patients with normocalcaemic tetany and hyperventilation syndrome (functional breathing syndrome), respectively, the parathyroid function was studied by means of the EDTA test according to Kaiser and Ponsold. In agreement with experimental results on inhibition of the parathyroid hormone release in magnesium deficiency patients with low serum magnesium concentrations show a pathological EDTA test signalling a relative parathyroid insufficiency.

Adolescent↗
PubMed1990

Measuring the impedance of erythrocytes in patients with cystic fibrosis.

A study of the dielectric properties of fresh, washed erythrocytes from three groups of 13 children, one with cystic fibrosis, and one each of healthy children of comparable age and comparable weight, was conducted after resuspension in their own plasma or in sodium phosphate buffer. The erythrocytes of the patients with cystic fibrosis showed significant variations in impedance, especially compared to the control group of comparable age. Further studies are required to ascertain whether these results are of diagnostic significance.

Child↗
PubMed1990

[Laboratory diagnostic monitoring of blood gas parameters in children during bronchologic studies].

Changes in PaO2 and parameters of acid-base-status during bronchological investigations were studied. 20 patients of both sexes with chronic nonspecific respiratory diseases have been investigated. The most important results were a respiratory acidosis after intubation and simultaneous hyperoxigenation during controlled (manual) ventilation. A respiratory acidosis with a small metabolic part was observed during extubation and change to normal respiration. In some cases acidosis was decomposated. These changes were found to be more extensive after bronchography than after bronchoscopy. Acidosis was normalized latest 60 minutes after extubation in all cases. The used method of bronchological examination has caused a favourable influence on the conditions of ventilation.

Acid-Base Equilibrium↗
PubMed1989

[A staged plan for laboratory diagnosis of hereditary metabolic diseases].

When clinical evidence provides grounds for suspecting inborn errors of metabolism it is urgent to perform the necessary, relevant, specific laboratory investigations in good time and with a view to quality. Normally, the realization depends on individual initiatives and the use of laboratories mainly designed for pediatrics and human genetics. Consequently the results are equally a matter of chance. Nothing in this situation can be changed in principle by using the catalogue of services of the Society for Human Genetics of the GDR. Central administrative provisions are necessary to improve the present unsatisfactory situation. Proposals for regulations, division of responsibility and a graduated programme of parameters are discussed here with a view to establishing uniform procedures.

Child↗
PubMed1985

[Hypomagnesemia and hypokalemia in the insulin hypoglycemia test].

In 17 children the insulin-hypoglycaemia-test was performed for the diagnostics of the hypophyseal growth hormone reserve and secretion. In the course of the insulin-hypoglycaemia test in 47% of the test persons hypomagnesaemias lower than 0.65 mmol/l and in all test persons hypopotassaemias lower than 4 mmol/l were measured. Besides hypoglycaemia and adrenergic contraregulation hypomagnesaemias and hypopotassaemias during the insulin-hypoglycaemia-test must be regarded as causal factors for cardiac risks and neuro-vegetative side-effects in the insulin-hypoglycaemia-test.

Adolescent↗
PubMed1981

[Photodynamic injuries of erythrocytes during illumination with blue light in patients with icterus neonatorum].

In a prospective study the influence of intermittent phototherapy (with and without riboflavin substitution) on red blood cells of newborns was examined in vivo. Hemoglobin concentration and hematocrit values did not differ significantly between treated patients and untreated controls. However, after illumination during 24 h (real exposure time 12 h) with a highly effective NC 400-04 Narva lamp, we found a completely reversible decrease of the mean erythrocyte diameters. The changes were statistically significant at the 8th day of life and disappeared up to the 16th day after birth. Riboflavin administration immediately before starting the phototherapy was able to prevent this phenomenon. The glutathione reductase activity (method by BEUTLER) was not affected, neither by phototherapy alone nor by riboflavin administered additively. As a conclusion of our results we would like to recommend a general riboflavin substitution in newborns after phototreatment.

Erythroblastosis, Fetal↗