Harpreet Kaur Saini | PubMed Health

PubMed2005

A putative novel alpha/beta hydrolase ORFan family in Bacillus.

A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the alpha/beta hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the alpha/beta hydrolase superfamily to which they may belong.

Amino Acid Sequence↗

PubMed2005

Meta-DP: domain prediction meta-server.

UNLABELLED: Meta-DP, a domain prediction meta-server provides a simple interface to predict domains in a given protein sequence using a number of domain prediction methods. The Meta-DP is a convenient resource because through accessing a single site, users automatically obtain the results of the various domain prediction methods along with a consensus prediction. The Meta-DP is currently coupled to 10 domain prediction servers and can be extended to include any number of methods. Meta-DP can thus become a centralized repository of available methods. Meta-DP was also used to evaluate the performance of 13 domain prediction methods in the context of CAFASP-DP. AVAILABILITY: The Meta-DP server is freely available at http://meta-dp.bioinformatics.buffalo.edu and the CAFASP-DP evaluation results are available at http://cafasp4.bioinformatics.buffalo.edu/dp/update.html CONTACT: hkaur@bioinformatics.buffalo.edu SUPPLEMENTARY INFORMATION: Available at http://cafasp4.bioinformatics.buffalo.edu/dp/update.html.

Algorithms↗