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Biomedical subjects

I A Klimenko

Publications and source records attributed to I A Klimenko.

At least 19 recordsLinked to original sources
PubMed2002

[Clinical and immunological studies of the therapeutical effect of cytokines combined with 5-fluorouracil in metastatic kidney cancer].

The authors present the results of a six-year clinicoimmunological study of a therapeutic effect of cytkins combined with 5-fluoruracyl in metastatic renal-cell carcinoma. Two therapeutic regiments have been used: rhIFN-a + 5-FU and rhIL-2 + RHifn-A + 5-FU. In cytokin-sensitive patients, both therapy protocols vrs conventional therapeutic alternatives (cytostatics, hormones, irradiation) have been shown to increase the frequency of achievement of remission by objective scoring and life span of the patients. There was an improvement in patients on having received the complex with IL-2 but a higher therapeutic effect appeared to be accompanied by substantial side effects. Recommendatory measures well-targeted to those patients with metastatic renal-cell carcinoma who are to be placed on cytokinotherapy are presented together with immunological indices to monitor the treatments administered and prognosis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Treatment of patients with stage I-II non-seminoma germ-cell tumors of the testis].

Stage I--II disease was identified in 71 out of 219 patients with nonseminomatous germ cell tumors of the testis. After orchifuniculectomy, polychemotherapy was given to 30 patients while the rest underwent transperitoneal lymphadenectomy. Long-term survival in the polychemotherapy group was 83.3%, in the lymphadenectomy one--95.1%. After excision of the retroperitoneal lymph nodes, the patients' follow-up should include regular assays of such tumor markers as alpha-fetoprotein and chorionic gonadotropin as well as X-ray examination of the chest for at least the first 24 months. Polychemotherapy should not be administered unless tumor dissemination or an increase in tumor marker levels are detected.

Adolescent↗
PubMed1988

[Effects of chemotherapy on regional metastases of non-seminomatous tumors of the testis].

A comparative evaluation of histologic patterns of non-seminomatous testicular tumors was carried out in 2 groups of patients: those receiving platinum derivative-based preoperative chemotherapy (31) and chemotherapy-free cases (36). Preoperative cytostatic treatment potentiated cell differentiation in retroperitoneal metastases in some patients, the latter effect being considered prognostically favorable.

Adult↗
PubMed1988

[Precancerous importance of chronic cystitis and papilloma of the bladder].

Analyzes the findings of histologic studies of biopsies of a pathologically changed and visually intact bladder mucosa from 334 patients with chronic cystitis with nonproliferative, proliferative, and metaplastic changes (n = 164), papillomas (n = 62), and carcinomas (n = 108). Demonstrates the relationships between these conditions and their evolution over a follow-up of 36-72 months. Outlines the most typical patterns of their development and progress eventuating in noninvasive or various forms of invasive carcinoma.

Biopsy↗
PubMed1986

[Electron microscopy in the diagnosis and prognosis of transitional-cell bladder tumors].

The electron-microscopic analysis of 65 different transitional-cell tumours of the urinary bladder revealed quantitative correlations between the tumour cells belonging to different groups, types and forms of transitional-cell papilloma, transitional-cell carcinoma and undifferentiated carcinoma of the bladder. These correlations are of importance for histogenetic and differential diagnosis of these tumours. The correlation between the changes in cell composition of transitional-cell papilloma or transitional-cell carcinoma and the subsequent clinical course of the disease (prognosis) is determined.

Carcinoma, Transitional Cell↗
PubMed1986

[Clinico-morphological characteristics of bladder leukoplakia].

A clinico-morphologic study was carried out in 63 patients suffering from leukoplakia of the urinary bladder. Certain differential diagnostic characteristics of clinical course and cystoscopic pattern of the disease as well as morphologic features of squamous cell metaplasia were identified. Malignant leukoplakia was registered in 12%. Papilloma and cancer concomitant to leukoplakia were detected in 22 and 27%, respectively.

Adult↗
PubMed1985

[Leukoplakia of the bladder].

The urinary bladder leukoplakia from 42 patients was studied clinico-morphologically, histochemically and electron microscopically. This precancerous condition is observed in 58,3 cases of chronic cystitis, more frequently in females. Three successive stages of the leukoplakia development under the conditions of the inflammatory process can be distinguished: squamous-cell modulation, squamous-cell metaplasia, squamous-cell metaplasia with keratinization. The formation of fissure-like intercellular bridges and the appearance of the long dense bundles of tonofibrils in the cytoplasm are the early ultrastructural signs of squamous-cell metaplasia of the transitional epithelium which are of the differential-diagnostic importance.

Adult↗
PubMed1978

[Late results of the combined treatment of bladder cancer depending on the histological form of the tumor].

The writers present an analysis of the remote results of the combination therapy in 208 patients with cancer of the urinary bladder, depending on the histological form of the tumor. Radical surgery was performed in 193 patients, palliative--in 15. All types of surgical intervention were associated with radiotherapy in the pre- and postoperative period. The survival for 3 years and longer was noted in 153 patients, for 5 years and longer--in 69. Transitional-cell papilloma is characterized by the most favourable prognosis.

Adult↗
PubMed1977

[Cryosurgical treatment of prostate gland cancer].

The authors share their experience with cryosurgical treatment of 38 patients with prostatic cancer (stage T3--in 9 patients, T4--in 29). The technic of cryotherapy is described. The former was employed in patients with complete obstruction of the cervico-urethral segment being nonresponsive to the hormone- and radiotherapy, and also for a life cystostome. Three freezing sessions for 5--15 minutes were conducted with natural warming of the prostate between sessions during 10--12 minutes, and forced warming for 3--4 minutes after the third session. The optimum time of cryoeffect was 5--7 minutes. The postoperative period was smooth, uncomplicated. The process of rejection of the frozen tissues lasted for up to 4--6 weeks, after that a suprapubic drainage was withdrawn and uresis was restored. 32 patients were discharged from the clinic, the survival up to 3 months--in 2, up to 6 months--in 6, up to 1 year--in 4, up to 2 years--in 7, up to 3 years--in 7.

Aged↗