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Biomedical subjects

I A Klimenko

Publications and source records attributed to I A Klimenko.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[The prognostic significance of the PCNA protein in transitional-cell bladder cancer].

1. Apparent expression of PCNA in different tumours should not be regarded as an unquestionable criterion of tumoral growth and progression but a negative result of an immunohistochemical assay for PCNA of certain human tumours is not to be taken as a proof that there is no tumoral growth whatever. 2. With results of the immunohistochemical study into the tumour for PCNA protein varying thus much, they are to be interpreted as different forms of manifestation of this protein gene abnormalities.

Carcinoma, Transitional Cell↗
PubMedDate not supplied

[Urinary bladder cancer in patients with tuberculous and post-tuberculous cystitis].

125 patients with tuberculous and posttuberculous cystitis were examined using cytological test of the aspirate from the bladder for atypical cells and histological investigation of the biopsy. Cancer of the bladder has developed in long-term chronic tuberculous or posttuberculous cystitis in 4% of the cases. The best objective method of the diagnosis was histological examination of the biopsy obtained from cancer-suspected sites of the bladder mucosa.

Adult↗
PubMedDate not supplied

[The use of lyophilized blood serum for determining the 3-HAA antigen in patients with precancerous diseases and cancer of the bladder].

3-OAK antigen was determined by immunodiffusion in agar by means of immune sera containing antibodies against 3-OAK. In patients with cancer of the urinary bladder the percentage of detecting 3-OAK-Ag in the native serum was 76.9 while in lyophilized it was 41.9. In patients with pretumorous diseases (leukoplakia, chronic cystitis, papillomas) their values were 64.1 and 56.1 respectively. It is concluded that lyophilized blood serum may be used in the clinical practice for immunological and serological examinations.

3-Hydroxyanthranilic Acid↗
PubMedDate not supplied

[The sanitary status of natural waters on the territory of Moscow (according to the results of the examination of chemical and radionuclide composition)].

The paper presents the results of examination of the chemical and radionuclide composition of natural waters and snow cover in Moscow. Areas with abnormal contents of tritium are found in the underground and surface waters and snow cover. The high concentrations of strontium, boron, fluorine, and barium are ascertained to be associated with natural factors. Areas of technogenically polluted underground waters are identified. Recommendations are given for further studies. Particular emphasis is laid on that the artesian wells that are a reservoir source of water supply under emergency are to be revised.

Barium↗
PubMedDate not supplied

[The diagnostic and prognostic value of tumor markers in nonseminomatous stage-III to -IV testicular tumors].

The effect of combined treatment was studied in 97 patients with nonseminomatous testicular tumors with regional and distant metastases with regard to the blood serum levels of alpha-fetoprotein and chorionic gonadotropin. The disease stage was found closely correlating with the efficacy of the treatment and the level of tumor markers. Complete remission was observed in 84.2 per cent (16 out of 19) patients with normal marker levels and in 26.8 per cent (11 out of 41) of those in whom both markers levels were raised (p less than 0.05). A continuous follow-up revealed that increased marker levels were the evidence of tumor relapse or metastases in clinically silent patients.

Adolescent↗
PubMedDate not supplied

[The effect of different types of recombinant interferon on the induction of 2,5-oligoadenylate synthetase in natural killers and the tumor cells in bladder cancer patients].

Recombinant interferon treatment of donors' and bladder cancer patients' lymphocytes results in activation of natural killer cells which is in correlation with enhanced activity of 2,5-oligoadenylate synthetase in them. The study of sensitivity of bladder cancer cell primary cultures showed that the cells are sensitive to various interferons virtually in all the cases observed as indicated by high synthetase activity. The baseline level of 2,5-oligoadenylate synthetase in tumor cells surpassed that in natural killers from healthy donors which may be related to elevated levels of serum gamma-interferon in the above patients.

2',5'-Oligoadenylate Synthetase↗