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Biomedical subjects

I Akesson

Publications and source records attributed to I Akesson.

26 records · Page 2Linked to original sources
PubMed1979

Uromucoid (Tamm-Horsfall's mucoprotein) in amniotic fluid and in urine in children.

Uromucoid (Tamm-Horsfall's mucoprotein) was not detected in amniotic fluid from pregnancies with gestational are 12-18 weeks, but was detected in 5 of 9 samples of amniotic fluid from full-term pregnancies, and in urine from all full-term infants investigated 1st day of life. This suggests that uromucoid excretion under normal conditions established near term. Change from intrauterine to extrauterine life may rapidly induce uromucoid excretion, as this protein was found in premature infants (32-34 weeks of gestation) at the 2nd day of life. Healthy newborn infants had a lower uromucoid concentration in urine than children 7--13 years old. In newborns with uncomplicated prematurity, idiopathic respiratory distress syndrome and full-term asphyxiated newborns, the uromucoid concentration in urine during the 1st week of life was not different from healthy newborn infants. Though uromucoid is found to be the major constituent of hyaline casts, the excretion of casts did not correlate to the uromucoid concentration.

Adolescent↗
PubMed1978

Uromucoid in normal urine.

Uromucoid was determined in urine from persons or various ages with normal kidney function by a radial immunodiffusion technique. Uromucoid concentration was inversely correlated to diuresis. Excretion rates showed a weak correlation to body surface area in young adults of both sexes. Children had a greater excretion of uromucoid per m2 than young adults, and even newborn had a considerable excretion. Elderly subjects had similar excretion rates to young adults. Excretion rates were uninfluenced by sex, salt load or diuresis, and no difference between day and night excretion rates was observed. Intraindividual fluctuations were small, and determination of uromucoid in one single night's urine therefore gives an adequate expression of the uromucoid excretion rate.

Adolescent↗
PubMed1978

Quantification of uromucoid: a simplified method.

As a replacement of current time consuming techniques, a radial immunodiffusion method which is suitable for routine determination of uromucoid in urine in described. The method is based on denaturation of uromucoid by sodium dodecyl sulphate at 37 degrees C before application on the immunoplates. A diffusion period of 30 h at 37 degrees C was chosen. The determination is uninfluenced by variations of urinary electrolytes, freezing and thawing, and storage at 4 degrees C for 3 weeks or at -20 degrees C for several months. The method can also be applied to lyophilized urines.

Electrophoresis, Polyacrylamide Gel↗
PubMed1977

Complement system studies in adult coeliac disease.

Detailed complement system studies were performed in 22 patients with adult coeliac disease. Activation products of C3 were observed in the fresh sera of all untreated patients, while only 4 had activation products of factor B of the alternate pathway. Levels of C4 and C3 were lower than normal mean, but only the depression of C4 reached a level of statistical significance. The amounts of circulating C3 activation products were significantly reduced when the patients were on a gluten-free diet. There is thus evidence that activation of the classical pathway of the complement system takes place in adult coeliac disease, and there is an association between gluten ingestion and the complement activity. We suggest that a possible mechanism of tissue injury in this disease is activation of complement factors by a humoral immune reaction to dietary gluten in the intestinal wall.

Adult↗
PubMed1976

Fibrin/fibrinogen degradation products (FDP) in urine and serum after prolonged heavy exercise.

The presence of FDP in the urine, known to be a sensitive indicator of various kidney disorders, was studied in 14 well-trained men participating in a 70-km cross-country ski race. None of the urine samples contained FDP on the day before the race. Immediately after the race, 4 samples contained FDP. High molecular weight FDP were found in 2 of them, whereas 2 others contained low molecular weight products only. 2 days after the race, 1 of these subjects still had FDP in the urine. In addition, 2 newly FDP positives were observed. Serum FDP were slightly elevated in 2 subjects before the race, and in another subject immediately after the race. The presence of urinary FDP did not correlate either with urinary albumin or uromucoid, or with serum FDP. A drop in plasma fibrinogen immediately after the race was noted in all subjects. It is suggested that the present observations may reflect a transient hyperproteolysis (coagulation and fibrinolysis) in the glomerular circulation, including fibrin formation and dissolution, associated with a transient damage of glomerular capillaries.

Adult↗
PubMedDate not supplied

Status of mercury and selenium in dental personnel: impact of amalgam work and own fillings.

Urinary mercury (U-Hg) and plasma mercury (P-Hg) levels were higher in 244 dental personnel than in 81 matched referents (U-Hg: 1.8 and 1.1 mumol/mol creatinine, respectively; p less than .001; P-Hg: 6.7 and 6.2 nmol/l, respectively; p = .03). The amalgam in the mouth influenced mercury levels in whole blood (B-Hg), plasma, and urine. The association was nonlinear: the more amalgam, the larger the relative increase in mercury levels. The number of amalgam surfaces accounted for more of the variance in blood and urine mercury levels than did the number of fillings (e.g., U-Hg: 44% and 36%, respectively). The estimated increases in mercury level with rising amalgam load were 3.0%, 2.0%, and 0.8% per filled surface for U-Hg, P-Hg, and B-Hg, respectively (p less than .0001 in all cases). The impact of occupational exposure on U-Hg in the dental personnel corresponded to approximately 19 amalgam surfaces. Ceramo metallic restorations were associated with higher (31%) U-Hg.

Adult↗