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Biomedical subjects

I B Lindén

Publications and source records attributed to I B Lindén.

5 recordsLinked to original sources
PubMed1979

The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse.

In the rat, administration of 3-(3,4-dihydroxy)-L-phenylalanine (L-dopa) simultaneously with the corresponding alpha-keto acid, 3,4-dihydroxyphenylpyruvic acid (DHPPA), gives significantly higher concentrations of L-dopa in the serum and of dopamine and homovanillic acid in the brain than the same dose of L-dopa alone. Correspondingly, DHPPA potentiates the effect of L-dopa on the locomotor activity in reserpine-treated mice. DHPPA is postulated to increase the absorption of intact L-dopa from the gut by preventing the transamination reaction between L-dopa and the physiological alpha-keto acids.

Animals↗
PubMed1976

A sensitive biological assay for prostaglandin E and acetylcholine.

Superfused hamster stomach strip has been used in the bioassay of prostaglandin E2 (PGE2) and acetylcholine. The preparation proved very stable and had no spontaneous movements. The sensitivity to PGE2 (and PGE1) was in the range of 10(-9) g ml(-1) and to acetylcholine 10(-12) g ml(-1). After treatment with physostigmine the sensitivity to acetylcholine was 10(-15) g ml(-1). In acetylcholine determination the preparation is more sensitive than any other method.

Acetylcholine↗
PubMed1976

Inhibition of prostaglandin biosynthesis by tolfenamic acid in vitro.

The effect of tolfenamic acid on prostaglandin biosynthesis was investigated by using rabbit kidney medulla microsomal fraction, and the results compared with those obtained with indomethacin and acetylsalicylic acid. Tolfenamic acid inhibited the conversion of arachidonic acid to prostaglandin E2 very effectively and in a dose-dependent manner. IC50 values were 0.64 muM for tolfenamic acid, 0.76 muM for indomethacin, and 7 mM for acetylsalicylic acid. The inhibition of prostaglandin biosynthesis may be related to the good anti-inflammatory action of tolfenamic acid.

Animals↗