The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse.

P Hietala; I B Lindén; N Grönfors

doi:10.1111/j.2042-7158.1979.tb13479.x

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The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse.

P Hietala·I B Lindén·N Grönfors

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Abstract

In the rat, administration of 3-(3,4-dihydroxy)-L-phenylalanine (L-dopa) simultaneously with the corresponding alpha-keto acid, 3,4-dihydroxyphenylpyruvic acid (DHPPA), gives significantly higher concentrations of L-dopa in the serum and of dopamine and homovanillic acid in the brain than the same dose of L-dopa alone. Correspondingly, DHPPA potentiates the effect of L-dopa on the locomotor activity in reserpine-treated mice. DHPPA is postulated to increase the absorption of intact L-dopa from the gut by preventing the transamination reaction between L-dopa and the physiological alpha-keto acids.

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Animals Biological Availability Brain Chemistry Dopamine Drug Interactions Homovanillic Acid Levodopa Male Mice Motor Activity Phenylpyruvic Acids Reserpine Comparative Study Journal Article

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P Hietala, I B Lindén, N Grönfors. 1979. The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse.. https://doi.org/10.1111/j.2042-7158.1979.tb13479.x

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