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Biomedical subjects

I Borisov

Publications and source records attributed to I Borisov.

At least 19 recordsLinked to original sources
PubMed2006

[A case report of two incidents of acute abdomen in a woman during pregnancy and in the early puerperium].

The authors present a case of a 32 year old pregnant woman who is admitted to the Obstetric clinic in the 16th gestational week with a pain in the ileoceacal region of the abdomen and vomitting. The woman has clinical signs of acute abdomen. A clinical diagnosis of acute appendicitis was suggested. During the operation under general anesthesia was found a phlegmonous inflammation of a Mekel diverticulus with perforation as well as local peritonitis and a catharal inflammation of the appendix. The appendix and the Mekel diverticle were removed during the operation. No comlications were observed during the post operative period. No fetal distress was observed during and after the operation Three months later the same patient was admitted to the obstetric clinic in the 32nd gestational week with a diagnosis Threatened premature delivery in ml VIII status post resection of a Mekel diverticle and appendectomy. The patient had pain to the right of the umbilicus and vomiting. The labor was induced and a viable premature infant was born. Two days after delivery there was again a clinical symptoms and signs of an acute abdomen due to ileus. A strangulation of the terminal ileum was found due to adhesions A Debridman and a lavage were performed No complications were observed during the postoperative period. The authors discuss the difficulties which might ensue when the diagnosis acute abdomen is made in a pregnant woman

Abdomen, Acute↗
PubMed2006

[The incidence of foetal macrosomia and method of delivery for a two-year period in the University Hospital of Obstetrics and Gynecology Maichin Dom--Sofia].

The authors carried out a retrospective study on the incidence of foetal macrosomia and the method of delivery on the 6157 consecutive births for a two-year period in the University Hospital of Obstetrics and Gynecology "Maichin Dom"- Sofia, Bulgaria. The incidence of foetal macrosomia (birth weight > 4000 g) among these births was 4,45% (274/6157 births). There was a coincidence between the admission diagnosis Macrosomia and the birth weight only in 8% of the cases. By Cesarean Section were delivered 117 macrosomic babies (42,7%): elective cesarean section had 89 patients - 32,48% (89/274) and emergency Cesarean section was done in 28 cases -10,2% Vaginal delivery had 157 patients - 57,3%. In this group 136 patients (86,33%) had normal vaginal delivery and 21 (13,37%) had operative vaginal delivery. (vacuum extractor, forceps, manual removal of the placenta). The authors found that the highest incidence of birth trauma was found in the cases where operative vaginal delivery was undertaken.

Bulgaria↗
PubMed2006

[The influence of chlamydial infection on the reproductive function in women with cervicitis].

The objectives of the present study were to determine the reproductive capacity and the most likely target groups for chlamydial infection in women with clinically manifested cervicitis. 2 To establish the impact of chlamydial infection on the reproductive function of the women with cervicitis. Chlamydial infection was diagnosed by direct immunofluorescence (DIF) in cervical smears. 553 sexually active women in reproductive age with clinically manifested cervicitis were examined. According to their chief complaint the patients were classified as: 1. Women with infertility 2. Oral contraceptive users 3. IUD users 4. Women with vaginal discharge and clinically manifested cervicitis 5. Pregnant women with signs of cervicitis. 6. Women with accompanying sexually transmitted infections. The results show that the predominant part of the women with chlamydial infection are in the age group 20-29 years (32,7% - 181/553). In this group chlamydial infection was most prevalent in oral contraception pill users /64/181 - 35,4%/ and those with vaginal discharge and clinically manifested cervicitis. 66/181 - 36,5%. Chlamydial infection as a cause of cervicitis was found in 14,6% of the pregnant women with cervicitis. Most of the positive for Chlamydia trachomatis patients had not given birth to a child and have not realized their reproductive potential.

Adolescent↗
PubMed2006

[The role of chlamydia trachomatis and some other associated microorganisms in endocervicitis].

The objective of the study was to examine the prevalence of Chlamydia trachomatis as a causative agent in women with clinically manifested endocervicitis and to find the age group where Chlamydia trachomatis was most prevalent. 553 women sexually active women in reproductive ag with clinically manifested endocervicitis e were examined. Chlamydial infection by direct immmunofluorescence was found in 239 (43, 2%) About 75% of the patients with chlamydial infection were in the age group 20-29 years. The predominant part of these women had no other associated infection except Chlamydia trachomatis. Association of Chlamydia trachomatis with candida albicans-25, 10%, bacteria vaginosis 23, 53%, Trichomonas vaginalis in 7.53% in the women with cervicitis.

Adolescent↗
PubMed2005

[Treatment of chronic recurrent vulvovaginal candidiasis with fluconazole (fungolon--Actavis)].

The object of the study was to evaluate the efficacy of peroral administration of Fluconazole (Fungolon caps. 50 mg - "Actavis") in dose 150 mg (3 caps. x 50 mg) once weekly for a period of 6 months. 50 female patients of reproductive age with chronic vulvovaginal candidiasis caused by C. albicans with three or more recurrences per year were enrolled in an open trial prospective study and 42 women were evaluated before and after treatment. Clinical improvement was observed in 81% of the patients after treatment Microbiological cure was observed in 86% of the patients (36/42). Positive cultures for C. albicans after treatment had 6 patients. Four of these 6 patients had duration of the chronic candidiasis for more than 3 years. Side effects during the treatment were not significant and might not be directly correlated with the administration of fluconazole. There was no cessation of therapy due to side effects. 53.3% of the patients accepted positively the long duration of therapy while 30% found the long duration of treatment a major inconvenience. Fluconazole is easily administrated well tolerated and is suitable for the long treatment of chronic vulvovaginal candididasis.

Administration, Oral↗
PubMed2003

Experimental cadmium poisoning in sheep.

Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.

Adrenal Glands↗
PubMed2003

[Comparative diagnostic characteristics of carbohydrate metabolism disorders in women with polycystic ovary syndrome (PCOS)].

The aim of the study was to compare the information provided by both fasting and stimulated during a standard oral glucose tolerance test (oGTT) levels of glucose and insulin as regards glucose tolerance and insulin resistance in women with PCOS. Few criteria are used in practice to verify insulin resistance in PCOS--elevated fasting insulin, decreased basal glucose/insulin ratio (< 6 for glucose in mg/dl or < 0.333 for glucose in mmol/l), insulin increase of more than 100 lul during an oGTT, and HOMA index > 2. The study comprised of 94 women (mean age 21.8 +/- 5 = 8 ys, mean BMI-30.38 +/- 7 = 7 kg/m2), divided in 4 groups according to BMI--group with BMI < 25, n = 21; group with BMI25-30, n = 27; group with BMI = 30-35, n = 23 and group with BMI > 35, n = 23. An oGTT with parallel determination of blood glucose and insulin was performed in all patients. The ratio basal glucose/insulin and HOMA index were calculated. Glucose levels on the 2 md hour during the oGTT pointed at IGT (impaired glucose tolerance) and/or diabetes in 8.5% of the investigated patients while the fasting levels indicated disturbances in only 2.2% of them. Fasting insulin levels were in the normal range in a considerable part of PCOSE women, mainly those with normal weight, and were not predictive for the response of insulin to glucose load. Relative percent of patients with elevated fasting insulin rose with the increasing of BMI. Decreased glucose/insulin ratio, elevated HOMA index, and abnormal stimulation of insulin were seen in more than 2/3 of the PCOS women including nonobese ones. Information provided by the above three markers was similar and they could be used alternatively according to the particular case and assessment of the cost/benefit ratio.

Adolescent↗
PubMed2000

[A comparative study between hysterosalpingography and laparoscopy in evaluating female infertility].

The diagnostic accuracy of hysterosalpingography and laparoscopy was compared. One hundred fourty three infertile women were prospectively investigated in two years duration. Laparoscopic chromopertubation using methylen blue dye performed on days 8-16. Hysterosalpingography performed on days 7-10 with water soluble contrast medium. There was agreement between the results of both methods in 66.4 per cent /95/ of the patients. In 15 of the 63 patients with a normal hysterosalpingography, however, peritubal or tubal disease was observed at the time of laparoscopy/false-negative results, 10.4%/Eighty patients with tubal obstructions were detected by hysterosalpingography, but 33 obstructions were not confirmed by laparoscopy/false-positive results, 23%/. The greatest discrepancy between the hysterosalpingography and laparoscopy was found in peritubal adhesions--58.7%. Laparoscopic evaluation demonstrated also endometriosis in 41 cases, poly cystic ovaries in 12, ovarian cyst in 9, and uterine fibroids in 15. Intrauterine abnormalities were diagnosed by hysterosalpingography in only 2.9% per cent of the patients. No significant laparoscopic complications were noted. The results suggest that hysterosalpingography is useful as a primary screening procedure, but laparoscopy provides a more accurate assessment of tubal patency and peritoneal factors in the investigation of infertility.

Adult↗
PubMed2000

[The correlation between intrauterine filling defects during hysterosalpingography and endometriosis at laparoscopy].

The association of intrauterine filling defects on hysterosalpingogram with endometriosis was evaluated. One hundred twenty patients were prospectively investigated with both methods, hysterosalpingography (HSG) and laparoscopy (LSC), for period of two years. HSG was performed on days 7-10 with water-soluble contrast medium. The presence of endometriosis was proved laparoscopically and scored according to the American Fertility Society classification. Forty-one women had endometriosis at LSC. In 25 of all 30 women with filling defects on hysterosalpingogram endometriosis was found. The presence of intrauterine filling defects on HSG is significantly associated with the presence of pelvic or peritoneal endometriosis.

Adnexal Diseases↗
PubMed2000

[Placental location and its influence on the position of the fetus in the uterus].

There are different opinions concerning the influence of the placental localization on the position of the fetus in the uterus. Two options are suggested in breech presentation--placenta praevia and cornual localization as possible causes for breech presentation. The aim of the present prospective study is to establish the influence of placental localization on the fetal position in the uterus. Two groups of pregnant women were examined--the first with cephalic resentation (n = 125) and the second with breech presentation (n = 124). All of the pregnant women examined were nulliparas, with term pregnancy (37-40 weeks). Uterine and fetal abnormalities were excluded. The localization of the placenta was determined by ultrasonography. The cornu-fundal localization of the placenta was found in 4.8% in the pregnant women with cephalic presentation and 62.6% in pregnant women with breach presentation. Placenta praevia or low insertion of the placenta was found in 3.2% of the cases with breech presentation and in none of the cases with cephalic presentation. The authors conclude on the basis of the data in the study that the localization of the placenta influences the fetal position in the uterus.

Breech Presentation↗
PubMed1999

[The most suitable tests for studying chlamydial infection in women with sterility].

The study was carried out on 280 infertile women (185 with primary and 95 with secondary infertility), patients of the University Clinic of Gynecologic Endocrinology and Infertility, Sofia. The present study was designed to estimate which is the most suitable test for detection of chlamydial infection in women with infertility. Evidence of past chlamydial infection was determined by the presence of antichlamydial IgG antibodies by commercial ELISA test. From 196 of the patients examined, 101 were positive for antichlamydial IgG antibodies (62.7%). 84 women were examined by means of direct antigen test for Chlamydia trachomatis from the endocervix (DIF. ELISA). Tubal patient was examined by means of hysterosalpingography and/or laparoscopy. In 34 women with unilateral or bilateral tubal occlusion the endocervical direct antigen test was positive in 4 (11.8%) and in 30 women with patient tubes 2 were positive by this test (6.7) In 38 women with tubal occlusion 29 of the women with unilateral or bilateral tubal occlusion had a presence of IgG antichlamydial antibodies in their sera (76.3%) compared to 17 of 38 women with patient tubes (44.7%). The results of the present study indicate that the examination antichlamydial IgG antibodies in the sera of women with infertility has a better predictive value with regard to tubal pathology compared to the direct antigen test for detection Chlamydia trachomatis in the endocervix. Examination for latent infection or reinfection has to be carried out before the administration of more invasive methods for the management of infertility.

Adolescent↗
PubMed1999

[Inflammatory gynecological diseases as a social problem in women of reproductive age].

Gynecological infections in women of reproductive age are connected with considerable economic losses both for diagnosis and treatment and for temporary disability. There are annually 12,000-15,000 pelvic infections in women of reproductive age in Bulgaria. Late sequel include infertility, ectopic pregnancy, chronic disability. The management of all these complications exceed considerably the expenses if proper diagnosis and treatment of the pelvic infections has been administrated. About 25% of the women who have had salpingitis are expected to be affected by infertility. The age group of women 20-25 years are the most affected. Most of these women have not accomplished their reproductive potential. The most frequent causes for pelvic infections are sexually transmitted pathogens and intrauterine manipulations--dilatation and curettage, IUDs. The necessity for control programs for prevention of sexually transmitted infections as well as education for diminishing unwanted pregnancy and abortions is pointed out.

Adult↗
PubMed1999

[The etiology of infectious cervicitis in women].

Infectious cervicitis is a common disease in women of reproductive age. A prospective study was carried out including 70 women with clinical manifestations of cervicitis during gynecological and colposcopic examination. In 19 women (27%), Chlamydia trachomatis was demonstrated by direct immunofluorescence in cervical smears. Neisseria gonorrhoeae was isolated in 2 women and 1 had a concomitant infection with Neisseria gonorrhoeae and Chlamydia trachomatis. Mycoplasma hominis and Ureaplasma urealyticum were isolated in 7 patients and 4 had cytological smears consistent with Human Papilloma Virus infection. In the rest 47 patients no etiological agent was found. The results of the present study indicate that the most common etiological cause for infectious cervicitis can be Chlamydia trachomatis and an examination for this organism should me mandatory in women with infectious cervicitis for guiding the correct diagnosis and treatment.

Adolescent↗
PubMed1999

[The correlation between the study data on the Papanicolaou cytological smear and the data on direct immunofluorescence for C. trachomatis].

A study was carried out to examine the relationship between the clinical data, the data from the Papanicolaou smear and the direct immunofluorescence for C. trachomatis in 70 women with infectious cervicitis. The prevalence of Chlamydial infection in the study population was 27%. The study showed that one third of the women in whom the Papanicolaou smear revealed inflammatory changes might be expected to be infected with C. trachomatis. The probability of not having infection when no inflammatory changes were observed in the Papanicolaou smear was 0.74--negative predictive value which means that more than two thirds of the women without inflammatory changes in cytology smear will not be infected with C. trachomatis.

Antigens, Bacterial↗
PubMed1999

[Therapeutic regimens for treating bacterial vaginosis in pregnant women].

The study comprises 128 pregnant women examined at different gestational weeks. The diagnosis of bacterial vaginosis was made using: a) the complex clinical criteria--vaginal discharge, vaginal pH, amine test and "clue cells" b) Nugent scoring system c) Spiegel criteria. Two therapeutic regimens were compared--intravaginal 2% clindamycin creme (Dalacin V) 5 g three consecutive days and intravaginal metronidazole (Flagyl) 500 mg once daily for 5 consecutive days. Control examination was carried out 5-7 days after completion of therapy using the same protocol. 28 women from the first group and 31 women from the second group had the control examination. Bacterial vaginosis was eradicated in 93% of women using intravaginal clindamycin and in 87% of women using intravaginal metronidazole. Both regimes were more effective compared to treatment with oral ampicillin for 7 days, where the cure rate was 62%.

Administration, Intravaginal↗
PubMed1999

[The effect of chlamydial infection on tubal patency].

The study was carried out on 162 infertile women (110 with primary and 52 with secondary infertility), patients of the University Clinic of Gynecologic Endocrinology and Infertility, Sofia. The present study was designed to estimate the effect of chlamydial infection as a cause of tubal pathology in infertile women. Evidence of past chlamydial infection was determined by the presence of antichlamydial IgG antibodies by commercial ELISA test. 101 of the patients examined were positive for antichlamydial IgG antibodies (62.3%). 76 women were examined for tubal patience by means of hysterosalpingography and/or laparoscopy. 38 women had patient tubes and 38 women had tubal occlusion (20 had bilateral and 18 unilateral occlusion). 29 of the women with unilateral or bilateral tubal occlusion had a presence of IgG antichlamydial antibodies in their sera (76.3%) compared to 17 of the women with patient tubes (44.7%). The risk for tubal obstruction in women with positive serology for Chlamydia is 3.22 compared to 0.85 risk in the women with negative serology for chlamydia. The results of the present study indicate that women with evidence of past chlamydial infection are 4 times more likely to have obstructed fallopian tubes compared to women who had no such evidence. It is mandatory to examine the patient for chlamydial serology at the beginning of the diagnostic protocol in order to ensure adequate management prior to more invasive procedures such as hysterosalpingography or laparoscopy.

Adult↗