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Biomedical subjects

I Borisov

Publications and source records attributed to I Borisov.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Problems of diagnosis and treatment of cervicitis].

Infectious cervicitis is a common disease in women of reproductive age. The symptoms are not characteristic and they are often neglected by the patient and the physician. Cervicitis is a very important clinical entity, because the infection can ascend to the genital tract. The most common causes for the infectious cervicitis are Chlamydia trachomatic and Neisseria gonorrhoeae. A variety of methods for the precise diagnosis must be employed--gynecologic examination, colposcopy, pathomorphology and cytology and bacteriological examination as well. Therapeutic modalities must include coverage for both Chlamydia trachomatis and Neisseria gonorrhoeae. Bacteriological test of cure is mandatory.

Adolescent↗
PubMed1999

[Current treatment of bacterial vaginosis].

Therapeutic options for the treatment of accurately diagnosed bacterial vaginosis are reviewed on the basis of current concepts for treatment of bacterial vaginosis. The importance for screening for bacterial vaginosis is pointed out especially before intrauterine procedures and in pregnant women at risk for premature deliveries. Treatment regimens for pregnant women are discussed as well. Emphasis is given to treatment modalities for recurrent bacterial vaginosis.

Administration, Oral↗
PubMed1998

[The obstetrical management of pregnant patients with spontaneous rupture of the fetal membranes after 37 weeks' gestation].

The purpose of the study was to analyze the obstetric management in pregnancies with spontaneous rupture of membranes (RM) after 37 w.g. and to find out is there a correlation between the cervical status and the pregnancy outcome. The study includes 66 primiparous women divided into two groups depending on the cervical status(CS) at admission: Group 1-44 patients with unfavourable cervix (PS < 4) according to the Bishop's original scoring system and Group 2-22 patients with favourable cervix (PS > 4). The delivery started spontaneously within the first 8 hours after the RM in 59% of the pregnant women with favourable cervix compared to 50% of women with PS < 4. There is no significant difference in the mean duration of the latent period between group 1 and 2-6.3 and 6.2 hours, respectively. The mean duration of delivery was 14.08 hours in Group 1 compared to 14.03 hours in Group 2. 72.7% of the pregnant women in Group 1 had normal vaginal delivery compared to 86.44% of the patients in Group 2. There were 3 newborn (one in Group 1 and 2 in Group 2) with signs of infection. There were no perinatal deaths. Postpartal endometritis was diagnosed in 2 of the patients with unfavourable cervix. There is no motivation to fear the development of ascendant infection in pregnancies with RM after 37 w.g. even if the time elapsed from the very beginning of the RM to the start of delivery is more than 24 hours. We favour both active and passive management of delivery in pregnancies with favourable cervix at the time of RM. We have to reevaluate the active approach in pregnancies with unfavourable cervix and ruptured membranes because of the higher incidence of operative deliveries because of non-progress of labour in these cases.

Adult↗
PubMed1998

[A new therapeutic approach in the treatment of genital chlamydial infections. Azithromycin (Sumamed)].

Azithromycin is a member of a new class of macrolides called azalydes. Although azithromycin resembles erythromycine there are significant differences in antibacterial activity and pharmacokinetic profile. Azithromycin is taken up by cells and the intracellular concentrations are significantly higher than serum concentrations. After a single oral dose of Ig, azithromycin has a long lasting effect--the tissue concentrations in the uterine and cervical tissues are kept above the minimal inhibitory concentration for Chlamydia trachomatis for more than 10 days. In order to achieve the maximal bioavailability and avoid side effects (gastrointestinal discomfort), azithromycin should be taken apart from meals (one hour before or two hours after meals). Azithromycin has no hepatotoxic potential and the possibility for drug interactions is not apparent. It is also recommended for use in pregnant women--FDA category B. A single oral dose of Ig azithromycin is the reasonable choice for the treatment of uncomplicated genital chlamydial infection.

Anti-Bacterial Agents↗
PubMed1998

[Ultrasonic methods for determining the volume of amniotic fluid in a complicated pregnancy: improved methods for the prognosis of the perinatal outcome].

Semiquantitative measurement of amniotic fluid volume (AFV) was used to predict the pregnancy outcome. In 229 high risk pregnancies, the AFV was assessed by 4 ultrasonographic methods, including our suggested one--the modified amniotic fluid index (MAFI). Abnormal perinatal outcome was defined as operative delivery sue to fetal distress (OD/FD), meconium passage, low 5 min. Apgar score, umbilical artery pH (< 7.2) and intrauterine growth retardation (IUGR). About 26.2%, 32.8%, 37.6%, 30.6% and 16.6% cases of OD/FD, meconium stained fluid, low 5 min. Apgar score, low pH and IUGR were identified with oligohydramnios compared with the normal fluid group, using MAFI (p < 0.000001). The MAFI showed higher significance than the other ultrasonographic (US) methods. With the relative screening performance the sensitivity of MAFI, amniotic fluid index (AFI), maximum vertical pocket (MVP) and tho-diameter pocket (TDP) depths were 91.9%, 70.2%, 58.9% and 32.8% respectively with OD/FD. Our results suggest that the AFV assessment by MAFI may be superior to the other US techniques and it may used in the testing protocols of antepartum fetal surveillance.

Amniotic Fluid↗
PubMed1996

[Clinico-microbiological findings in women with a genital discharge].

The authors compare the prevalence of the most common vaginal infections at present and before 10 years and find that the prevalence of Trichomonas vaginalis infection is diminished and there is a tendency for the increase in the incidence of bacterial vaginosis. The determination of the vaginal pH and the application of 10% KOH for the "sniff test" may prove very useful in the diagnosis of vaginal infection.

Adolescent↗
PubMed1996

[The bacterial vaginosis problem].

The changing concepts through the years concerning this condition are briefly reviewed. The pathogenesis of the cardinal symptoms are explained, concerning the changes in the vaginal ecosystem. The importance of the complex clinical criteria is pointed out including the determination of the vaginal pH, the test with 10% KOH and the observation of "clue cells".

Adult↗
PubMed1996

[The bacterial vaginosis problem. II. The microbiology of bacterial vaginosis].

Microbial species in the vaginal content of healthy woman in her reproductive age were described, as well as the importance of hydrogen peroxide (H2O2) producing Lactobacillus spp. The characteristics of the basic microbial species associated with the BV was presented. Discussed were the various possible methods for BV diagnosing. The coloured microscopic preparation was accepted and applied as the main one in the routine practice.

Bacteria↗
PubMed1996

[The premenstrual syndrome in adolescents].

The premenstrual syndrome is associated with the appearance of distressing somatic, physiological and behavioural symptoms at a certain phase of the menstrual cycle and has not been sufficiently studies with adolescents. The aim of this study is to determine the frequency, severity and period of appearance of the more important somatic and psychological symptoms characteristic of adolescents with PMS. The study includes 186 girls at an age between 16 and 18 years monitored for the period of one year and four months. The most frequently met somatic symptom is headache (39%), the most frequent psychological one--irritability (46%). Sufficient attention is paid to the influence of the menarche and cigarette smoking in adolescents with PMS.

Adolescent↗
PubMed1996

[The relationship between simple and atypical endometrial hyperplasia and endometrial carcinoma].

The study was carried on 101 women in the perimenopause and postmenopause. The patients were divided into three groups, according to the results of the pathomorphological examination: I group--patients with simple hyperplasia; II group--patients with atypical hyperplasia; III group--patients with endometrial carcinoma. The simple hyperplasia predominates in the perimenopause, while the endometrial carcinoma was the most frequent cause for metrorrhagia in the postmenopausal women. When the endometrial carcinoma was combined with hyperplasia there were higher differentiation and less invasiveness of the endometrial carcinoma in these cases.

Adult↗
PubMed1995

[The direct immunofluorescence test for the diagnosis of Chlamydia trachomatis in gynecology].

Using the direct immunofluorescent test Chlamyset antigen for detection of Chlamydia trachomatis antigens, the authors examined 176 gynecologic patients. The prevalence of chlamydial infection in this population was 26.1%. The method for detection of C. trachomatis using the direct immunofluorescent test is described in detail. The results of the study show the significant role of C. trachomatis as a cause of gynecologic pathology--it was detected in cases of endocervicitis in 28.8% in pelvic inflammatory disease in 34.7%, in sterility patients in 18.8%. The authors conclude that the proper diagnosis and management of these gynecologic disorders requires the routine use in the clinical practice reliable diagnostic tests for detection of C. trachomatis and the direct immunofluorescent test is very useful for this purpose.

Adult↗
PubMed1995

[A comparison of Clearview Chlamydia diagnostic tests and direct immunofluorescence (Chlamyset Antigen) in inflammatory gynecological diseases due to Chlamydia trachomatis].

The diagnostic performance of two direct antigen tests is compared, using parallel samples from 90 gynecologic patients. The latter were selected because of clinically suspicious symptoms for chlamydial infection. The incidence of infection in the study group was 33.3%. Compared to direct immunofluorescence Clearview Chlamydia had sensitivity of 80%, specificity of 100%, and the agreement between the two methods was 93.3%. Clearview Chlamydia may serve as a useful diagnostic test in case there is no available laboratory equipment and trained personal.

Adolescent↗
PubMed1995

[The relationship between genital chlamydial infection and the presence of cervical intraepithelial neoplasia].

A study was carried out on 128 women with clinical signs of cervicitis. Direct immunofluorescence was used for the diagnosis of genital chlamydial infection. 46 (of total 128) were positive for C. trachomatis. (35.9%). Abnormal colposcopic findings were found in 38 women cervical biopsies were taken in 52 women. 8 women were positive for C. trachomatis in the group with abnormal colposcopic findings. 24 were positive for C trachomatis in the group, where cervical biopsies were taken. Comparing the results it was found that genital chlamydial infection did not influenced directly the development of cervical intraepithelial neoplasia.

Adolescent↗
PubMed1994

[Changes in the weight of the uterus, ovaries and adrenal glands in sexually mature rats treated with estradiol and reserpine].

Immature rats of the Wistar strain were used for the experiments. The treatment was administrated on the 35, 36, 37th day after delivery. The animals were divided into 4 groups. The first group received only saline solution, the second group were treated with reserpine, the third group with estradiole, and the forth group with both reserpine and estradiole. The animals were sacrificed on the 38th day after delivery. There was a statistically significant increase in the weight of the uterus and the ovaries after treatment with estradiole alone, and the same was observed for the group treated with reserpine and estradiole. The latter showed less increase in the uterine weight, which might be due to an impairment of estradiole synthesis caused by reserpine. The wight of the adrenal glands of the immature female rats was increased after treatment with estradiole and reserpine. This implies an involvement of the adrenergic system in the interaction between estradiole and testosterone in immature rats.

Adrenal Glands↗