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Biomedical subjects

I Borisov

Publications and source records attributed to I Borisov.

72 records · Page 4Linked to original sources
PubMed1986

[Pathomorphological changes in experimental Erysipelothrix infection in lambs].

Investigations were carried out with eight lambs treated i/v with a broth culture of Erysipelothrix rhusiopathiae at the rate of 10(8) microbial cells per 1 cm3. Following infection the lambs developed polyarthritis. Studied were the morphologic changes in both dead and slaughtered lambs at various intervals after the infection was performed. It was found that from the 2nd up to the 7th day the lesions were characterized by moderate infiltration (neutrophil granulocytes) of the parenchymal organs as well as by dystrophic- and necrotic foci in the liver and hyperemia, edema, and hemorrhages in the spleen, lung, and brain. After the 7th day were found reticulohistiocytic proliferations in the liver and heart, and intracapillary glomerulonephritis, thromboendocarditis, and polyarthritis.

Animals↗
PubMed1986

[Effect of the herbicide Herbazin-50 (simazine) on the wound process in animals].

Herbazin 50 was used as an experimental model to record species differences in the process of wound healing in horses, cattle, and sheep. It was established that the local and oral application of this herbicide inhibited wound healing, and this effect was more strongly manifested in the phase of hydratation. There were clearly expressed species-associated variations: in horses the elimination of the irritant was achieved through a severe inflammation response of a purulent character, while in cattle the rapid response of the connective tissue was leading, with concurrent premature maturation. Changes set in under the effect of the herbicide, consisting in the alkalinization of the wound exudate, which led to changes in the wound microflora.

Administration, Oral↗
PubMed1986

[Necrosis of the tail in buffaloes].

Clinical, microbiological, and biochemical indices and X-ray examination revealed that disturbed metabolism and the development of dystrophic processes in the derma and epidermis and the last tail vertebrae were to be incriminated as predisposing factors contributing to tail necrosis. There were fissures in the epidermis, thickening of its layers, and hyperkeratosis with necrotic suppuration of the surface and deposition of detritus. After microbial contamination necrosis of the distal portion of the tail set in.

Animal Diseases↗
PubMed1985

[Biochemical changes in the blood of sheep with experimental Corynebacterium infection].

Investigations were carried out with 24 sheep divided into two groups of twelve animals. The first group were infected via the lateral recessus of the tarsal joint with 2 cm3 of a 24-hour broth culture of Corynebacterium pyogenes, and the second one were infected i/v with 3 cm3 of the same culture. The changes in the total protein, protein fractions, and blood electrolites in the blood were followed up. It was found that the infection of Corynebacterium pyogenes affected the total reactivation of the animals and led to immunobiologic reconstruction changes. There were hyperproteinemia which depended on the route of infection as well as the severity of its course, and hyperglobulinemia which was "at the expense of' blood albumin. Noticed were also hypercalcemia, hyperpotassemia, and lower sodium and phosphorus levels.

Animals↗
PubMed1985

[Pharmacokinetics of amoxicillin trihydrate in sheep infected experimentally with Corynebacterium pyogenes and Escherichia coli].

A comparative experiment was carried out with sheep that were infected i/v and via the joints with Corynebacterium pyogenes and Escherichia coli, and with normal sheep left as controls. The pharmacokinetic parameters were determined of amoxicillin-trihydrate following its i/m application to all animals in a 20 percent oil suspension. It was found that there was delayed excretion of the antibiotic, and as a rule it was maintained in higher concentrations in the diseased animals. the differences were likely to be due to changes in the metabolic processes and to injury of the kidneys.

Amoxicillin↗
PubMed1985

[Effect of ultraviolet-irradiated autologous blood on the biochemical indices of sheep with a Corynebacterium infection].

Twelve sheep were used in two groups of six animals each (a control and a test one). Both control and test animals were infected with a 24-hour broth culture of Corynebacterium pyogenes. The infection was followed up in the course of five days after which the animals of both groups were subjected to autohemotransfusion, whereas the blood transfused with the controls was not treated, and the blood transfused with the test animals was treated with ultra violet rays in vitro. Following the transfusion of both untreated and treated blood the amount of blood sugar rose, it reaching higher levels in the case UV-treated blood. There were changes in the total protein and the protein fractions induced by the Corynebacterial infection, however, the initial levels were more rapidly restored in the case of transfusing UV-treated blood. With autohemotransfusion the values of glutamate-oxalacetate transaminase and glutamate-pyruvate transaminase in all animals dropped. The change was more rapidly and more strongly expressed with the transfusion of UV-treated blood.

Alanine Transaminase↗
PubMed1985

[Clinical, radiotelemetric and x-ray research on erythematous polyarthritis in lambs].

Experimental investigations were carried out with 6 lambs each infected i/v with 2 cm3 of a 24-hour broth culture of Erysipelothrix rhusiopathiae rated at 10(8) microbial cells per cu. cm. The clinical state of the animals was followed up in the course of 60 days, the changes in the cardiovascular system and those in the movements of the rumen being recorded radiotelemetrically, while the changes taking place in the joints were studied roentgenographically. It was found that the causative agent of swine erysipelas was strongly pathogenic for the lambs following a hematogenic infection, causing polyarthritis with concurrent changes in the general state--rise of temperature and higher respiration and pulse rates. The electrocardiograms of the affected animals showed sinus tachycardia, participation of Q waves, and changes in the R and T waves, while the graphic records of the rumen showed a drop in the number of rumen contractions and decrease in the amplitude. Roentgenographically, there were periostitis and osteoarthritis of the carpal and tarsal joints.

Animals↗
PubMed1985

[Morphological and biochemical changes in the blood of lambs with experimental Erysipelothrix polyarthritis].

Polyarthritis was induced in lambs via the i/v infection with 2 cm3 of 24-hour Erysipelothrix rhusiopathiae broth culture, which led to distinctive morphologic and biochemical changes in the peripheral blood. The hemoglobin content, the erythrocyte count, and the hematocrit value dropped, while ESR rose with the development of the infection process. The white blood picture presented transient and slight drop of the leukocyte count followed by leukocytosis with shifting to the left, aneosinophilia, lympho- and monopenia in the acute stage, and well manifested eosinophilia in the chronic stage of the infection. The changes in the total protein and the protein fractions consisted in hypoproteinemia in the first days following infection, hypoalbuminemia during the entire period, and hyperproteinemia and hypergammaglobulinemia in the chronic stage. The changes in the blood electrolites consisted in the rise of Ca and K, the drop of Na, and transient changes in the level of P, tending toward a rise in the chronic stage. It was also established that the values of sialic acid were raised in the entire period of polyarthritis development, while those of aspartate aminotransferase and alanine aminotransferase were higher in the first seven-day period only.

Animals↗
PubMed1984

[Effect of herbazin 50 on the course of suppurative surgical infection in sheep].

Twelve sheep, divided into two groups of 6 animals each, were used. The first (test) group was offered herbazin -50 with the feed in the course of 90 days after which the animals were infected via the joints with Corynebacterium pyogenes. The second (control) group was also infected with the same pathogen in the same way. During the time the preparation was given and 30 days post infection the animals were kept under observation, following up their clinical, condition, and the occasional morphological and biochemical changes taking place in the blood and the immunobiologic responsiveness. It was found that sheep treated with herbazin -50 with a following infection with Corynebacterium pyogenes raised their blood levels of sugar, total protein, potassium, sodium, magnesium, SGOT, SGPT, and manifested an increased ESR, and lower calcium, inorganic phosphorus, carotene, vitamin A, and cholesterine serum level. It was also established that surgical infections brought about through such introduction of C. pyogenes developed much more rapidly and ran a much more severe course in sheep after the preliminary treatment with herbazin -50. It is believed that they emerged after suppressing the immunologic responsiveness with the use of the preparation.

Animals↗
PubMed1984

[Clinical and hematological studies in experimental Corynebacterium infection in sheep].

Investigation were carried out with 24 sheep divided into groups of 12 animals each. The first group was subjected to the intrajoint infection via the lateral recess of the tarsum, using 2 cm3 of a 24-hour broth culture of Corynebacterium pyogenes for each animal, and the second one--to the i/v injection of 2 to 4 cm3 of the same broth culture. The clinical state and the morphologic changes in the blood were followed up in the course of 28 days. It was found that with such experimental suppurative surgical infection, caused by Corynebacterium pyogenes, there set in changes in the body temperature, and the pulse and respiration rates regardless of the route of infection. Both the haemoglobin and the erythrocyte count dropped, and the erythrocyte sedimentation rate rose, and the latter was found to be due to the change in the total erythrocyte count. The intrajoint infection of the sheep led the rise of the total leukocyte count, while the i/v infection lowered it. Both test groups displayed aneosinophilia, neutrophilia, lymphopenia, and rise of the monocyte count, which depended on the way of infection and its clinical course. The suppurative surgical infection caused by intrajoint introduction of these bacteria set in at a slower rate and lasted for a longer time as against the single i/v infection.

Animals↗
PubMed1982

[Effect of the in vitro ultraviolet irradiation of autogenous blood on hematological, biochemical and biological indices in sheep with experimentally induced sepsis].

Studies were carried out with 10 sheep infected with a 24th hour broth culture of strain 1088 of Corynebacterium pyogenes. The animals were divided into two groups of 5 each--control and test. Autotransfusion of untreated blood was carried out with the control group, and autotransfusion of UV-treated (in vitro) blood--with the test group. Used was a M-LK5 type lamp, and irradiation lasted 10 min. The autotransfusion of both treated and untreated blood was well tolerated by the sheep. It did not cause deviations from the normal clinical indices. It was established that the autohemotransfusion with untreated blood did not bring about changes in reactions that could be clinically followed up in the course of the disease. On the other hand, the autohemotransfusion of blood that was treated in vitro with ultra-violet rays had a beneficial effect on the body as a whole and on the individual clinical indices.

Animals↗